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Which of the following choices is a schedule I controlled substance?
a. Marijuana
b. Propranolol
c. Amphetamine
d. Dextropropoxyphene (Darvon) - CORRECT ANSWER-a. Marijuana
2. In comparing two drugs, the dose-response curve for the drug that is more efficacious would:
a. Be closer to the y axis
b. Be farther from the y axis
c. Have a greater curve height
d. Have a higher median effective dose (ED 50 ) - CORRECT ANSWER-c. Have a greater curve
height
Which of the following statements is true regarding drug potency and efficacy?
a. Drug potency and efficacy have a synergistic relationship, meaning that the whole is greater
than the parts.
,b. Drug potency and efficacy show a positive correlation.
c. Drug potency and efficacy show a negative correlation.
d. Drug potency and efficacy are unrelated. - CORRECT ANSWER-d. Drug potency and efficacy
are unrelated.
Potency definition: - CORRECT ANSWER-the function of an amt. of a drug required to produce
an effect
Efficacy definition: - CORRECT ANSWER-the max. intensity of effect or response that can be
produced by a drug
do drugs of greater potency require as high a dose. - CORRECT ANSWER-No
Which of the following statements is true regarding chemical signaling among cells?
a. Acetylcholine is the sole neurotransmitter capable of traveling across the synapse to a
receptor.
b. Prostaglandin and histamine are examples of chemicals that are released into the systemic
circulation.
c. Hormones are secreted to produce effects throughout the body.
d. Reactions to hormones are usually more rapid than those associated with neurotransmitters.
- CORRECT ANSWER-c. Hormones are secreted to produce effects throughout the body.
Which of the following statements is true concerning the mechanism of action of drugs?
a. Drugs are capable of imparting a new function to the organism.
b. Drugs either produce the same action as an exogenous agent or block the action of an
exogenous agent.
c. Drugs either produce the same action as an exogenous agent or block the action of an
endogenous agent.
,d. Drugs either produce the same action as an endogenous agent or block the action of an
endogenous agent. - CORRECT ANSWER-d. Drugs either produce the same action as an
endogenous agent or block the action of an endogenous agent.
When different drugs compete for the same receptor sites, the drug with the stronger affinity
for the receptor
will bind to:
a. More receptors than the drug with the weaker affinity
b. Fewer receptors than the drug with the weaker affinity
c. All of the available receptors
d. None of the available receptors - CORRECT ANSWER-a. More receptors than the drug with
the weaker affinity
When a drug has affinity for a receptor and produces no effect, it is called a(n):
a. Agonist
b. Competitive antagonist
c. Competitive agonist
d. Physiologic agonist - CORRECT ANSWER-b. Competitive antagonist
A noncompetitive antagonist:
a. Binds to the same receptor site as the binding site for the agonist
b. Causes a shift to the right in the dose-response curve
c. Enhances the maximal response of the agonist
d. Reduces the maximal response of the agonist - CORRECT ANSWER-d. Reduces the maximal
response of the agonist
Which of the following is not a subject of pharmacokinetics?
a. Physiologic action of drugs
, b. Metabolism of drugs
c. Elimination of drugs
d. Absorption of drugs - CORRECT ANSWER-a. Physiologic action of drugs
Which of the following choices is the process by which a substance is transported against a
concentration
gradient?
a. Passive transfer
b. Active transport
c. Facilitated diffusion
d. Filtration - CORRECT ANSWER-b. Active transport
Which of the following statements is true concerning passage across body membranes?
a. The membrane lipids make the membrane relatively permeable to ions and polar molecules.
b. The lipid molecules orient themselves so that they form a fluid bimolecular leaflet structure
with the
hydrophobic ends of the molecules shielded from the surrounding aqueous environment.
c. Membrane carbohydrates make up the structural components of the membrane and help
move the molecules
across the membrane during the transport process. - CORRECT ANSWER-b. The lipid molecules
orient themselves so that they form a fluid bimolecular leaflet structure with the
hydrophobic ends of the molecules shielded from the surrounding aqueous environment.
Drugs that are weak electrolytes will cross body membranes best when they are (1) nonionized,
(2) ionized,
(3) polar, (4) nonpolar, (5) lipid soluble, (6) water soluble.
a. 1, 3, 5
b. 1, 3, 6