WGU C785 Biochemistry Unit
Questions 2026 Exam All
Answers and Illustrations
Given
Which level of protein structure is disrupted through the hydrolysis of
peptide bonds?
Quaternary
Tertiary
,Primary
Secondary - ANSWER ✔✔Primary
The primary structure of a protein is the sequence of amino acids held
together by peptide bonds. Peptide bonds are formed by dehydration
reactions and disrupted by hydrolysis.
A mutation in the beta-hemoglobin gene, which results in the
replacement of the amino acid glutamate in position 6 with the amino
acid valine, leads to the development of sickle cell anemia. The
structures of glutamate and valine are shown below.
If the beta hemoglobin gene in a patient with sickle-cell anemia were to
be edited so that the valine in position 6 was replaced with a different
amino acid, which replacement for valine would be expected to have the
best clinical outcome, in theory, for the patient? (Assume the valine can
potentially be replaced with any amino acid other than glutamate.) -
ANSWER ✔✔The original amino acid in a healthy patient is
glutamate, which is negatively charged. The mutated amino acid is
valine, which is non-polar. Valine is causing sickle cell anemia. The best
,amino acid to replace valine so that the patient is healthy again would be
the one most like glutamate, so any negatively charged amino acid.
Secondary, tertiary, and quaternary levels of protein structure can all be
impacted by exposing a protein to which treatment?Change of a
hydrophobic amino acid to a different hydrophobic amino acidAddition of
a reducing agentPlacement of the protein in a solution with a low
pHIncrease in the concentration of the protein in solution - ANSWER
✔✔Placement of the protein in a solution with a low pH
Changes in pH affect hydrogen bonds and ionic bonds. Hydrogen bonds
in the backbone of amino acids occur in secondary structure, and both
hydrogen bonds and ionic bonds occur in the side chains of amino acids
in tertiary structure.
An increase in beta-pleated sheet structure in some brain proteins can
lead to an increase in amyloid deposit formation, characteristic of some
neurodegenerative diseases. What is the primary biochemical process
that follows the increase in beta-pleated sheet structure that leads to the
development of the amyloid deposits?
An increase in glycogen formation in the brain cells
COPYRIGHT©PROFFKERRYMARTIN 2025/2026. YEAR PUBLISHED 2026. COMPANY REGISTRATION NUMBER:
619652435. TERMS OF USE. PRIVACY STATEMENT. ALL RIGHTS RESERVED
, Aggregation of the proteins in the brain
Secretion of glucagon, leading to excessive ketogenesis
An increase in anaerobic metabolism of glucose in the brain -
ANSWER ✔✔Aggregation of the proteins in the brain
This question is describing changes in protein structure. Aggregation
occurs when proteins clump together inappropriately, causing plaques
like amyloid deposits to accumulate.
Which level of protein structure is determined by the sequence of amino
acids?
Secondary structure
Quaternary structure
Questions 2026 Exam All
Answers and Illustrations
Given
Which level of protein structure is disrupted through the hydrolysis of
peptide bonds?
Quaternary
Tertiary
,Primary
Secondary - ANSWER ✔✔Primary
The primary structure of a protein is the sequence of amino acids held
together by peptide bonds. Peptide bonds are formed by dehydration
reactions and disrupted by hydrolysis.
A mutation in the beta-hemoglobin gene, which results in the
replacement of the amino acid glutamate in position 6 with the amino
acid valine, leads to the development of sickle cell anemia. The
structures of glutamate and valine are shown below.
If the beta hemoglobin gene in a patient with sickle-cell anemia were to
be edited so that the valine in position 6 was replaced with a different
amino acid, which replacement for valine would be expected to have the
best clinical outcome, in theory, for the patient? (Assume the valine can
potentially be replaced with any amino acid other than glutamate.) -
ANSWER ✔✔The original amino acid in a healthy patient is
glutamate, which is negatively charged. The mutated amino acid is
valine, which is non-polar. Valine is causing sickle cell anemia. The best
,amino acid to replace valine so that the patient is healthy again would be
the one most like glutamate, so any negatively charged amino acid.
Secondary, tertiary, and quaternary levels of protein structure can all be
impacted by exposing a protein to which treatment?Change of a
hydrophobic amino acid to a different hydrophobic amino acidAddition of
a reducing agentPlacement of the protein in a solution with a low
pHIncrease in the concentration of the protein in solution - ANSWER
✔✔Placement of the protein in a solution with a low pH
Changes in pH affect hydrogen bonds and ionic bonds. Hydrogen bonds
in the backbone of amino acids occur in secondary structure, and both
hydrogen bonds and ionic bonds occur in the side chains of amino acids
in tertiary structure.
An increase in beta-pleated sheet structure in some brain proteins can
lead to an increase in amyloid deposit formation, characteristic of some
neurodegenerative diseases. What is the primary biochemical process
that follows the increase in beta-pleated sheet structure that leads to the
development of the amyloid deposits?
An increase in glycogen formation in the brain cells
COPYRIGHT©PROFFKERRYMARTIN 2025/2026. YEAR PUBLISHED 2026. COMPANY REGISTRATION NUMBER:
619652435. TERMS OF USE. PRIVACY STATEMENT. ALL RIGHTS RESERVED
, Aggregation of the proteins in the brain
Secretion of glucagon, leading to excessive ketogenesis
An increase in anaerobic metabolism of glucose in the brain -
ANSWER ✔✔Aggregation of the proteins in the brain
This question is describing changes in protein structure. Aggregation
occurs when proteins clump together inappropriately, causing plaques
like amyloid deposits to accumulate.
Which level of protein structure is determined by the sequence of amino
acids?
Secondary structure
Quaternary structure
