MODULE I Drugs
Useful links:
Drug Pharm Group Pharm Effect MoA Indication Side Effects Contraindication https://www.youtube.com/watch?v=0hVaO1rlXus&list=PLekhl8ZQS2PahYNzzQow72dLyLAXj2dDJ
Cholinergic drugs https://www.youtube.com/channel/UCIzOHtZa0iOH49ez1O5mReQ
Bronchospasm,
Parasympatholytic, Mydriasis, Direct antagonist of Muscarine
atropine sulphate Direct-acting M- Tachycardia, ↓Gland muscarinic ACh poisoning,
Cholinoblocker secretion, etc receptor Fundoscopy,
Cramps
Parasympathomim Direct agonism of
pilocarpine Miosis, Bracychardia,
etic, Direct-acting muscarining ACh Glaucoma
hydrochloride etc
M-Cholinomimetic receptor
Reversible
Cholinesterase
inhibitor, Non-
Anticholinesterase, Forms covalent Myasthenia
neostigmine selective
Bradycardia, Miosis, bond with gravis,
(Proserine) Cholinergic
etc acetylcholinesterase Glaucoma
Agonist,
Parasympathomim
etic
Non-selective
Binding to
direct-acting Short term
suxamethonium cholinergic receptors
cholinergic Myorelaxation surgery, electric
(Dithyline) and preventing
Antagonist, shock therapy
further stimulation
Myorelaxant
tiotropium Blocking muscarinic
Parasympatholytic, Asthma, Chronic
bromide Bronchodialation (M3) acetycholine
M-cholinoblocker bronchitis
(Ipratropium) receptor
Blocking
Parasympatholytic, ↓Gastric secretion, muscarininc (M1)
pirenzepine Peptic ulcer
M-Cholinoblocker ↓Muscle spasm acetycholine
receptor
Adrenergic drugs
Sympathetic effects,
↑HR, ↑BP,
Sympathomimetic,
Vasoconstriction, Anaphylaxis,
epinephrine Direct-acting Non- Agonism of a & B
↑Glycogenolysis, Cardiac arrest,
(Adrenaline) Selective adrenergic receptors
↑Gluconeogenesis, Bronchospasm
Adronergic Agonist
Bronchodilation,
Mydriasis
Nasal
phenylephrine Selective a1- Vasoconstriction, Agonism of a1 congestion,
(Mesaton) Adrenergic Agonist Mydriasis, ↑BP Adrenergic receptors Postsurgical
hypotension
Non-selective Beta
Adrenergic blocker, Hypertension,
propanolol ↓HR, Hypotensive, Antagonism of B
Antihypertensive, Arrhythmia,
(Anapril) Antianginal adrenergic receptor
Antiarrhythmic, Angina
Antianginal
B1-Adrenergic
Antagonism of B Hypertension,
metroprolol blocker, ↓HR, Hypotensive
adrenergic receptor Arrhythmia
Antihypertensive
B1-Adrenergic Agonism of B1 Cardiac
dobutamine Inotropic effect
agonist Adrenergic receptor decompensation
albuterol B2-Adrenergic Agonism of B2 Bronchospasm,
Bronchodilation
(Salbutamol) agonist Adrenergic receptor Asthma
Blocking
Adrenoblocker, ↓BP, Bradycardia, catecholamine
reserpine Hypertension
Antihypertensive ↓BP transport to vesicles
in synapses
B1-Adrenoblocker, Antagonist of B1-
bisoprolol ↓HR, ↓BP Hypertension
Antihypertensive Adrenergic receptor
Antagonism of B,a1-
carvedilol B,a1-Adrenoblocker ↓HR, Miosis, ↓BP Hypertension
Adrenergic receptors
Antagonism of a1-
doxazosin a1-Adrenoblocker Vasodilation, ↓BP Hypertension
Adrenergic receptor
Sympatholytic, a2- Agonism of a2-
methyldopa ↓BP, ↓Norepinephrine Hypertension
Adrenergic Agonist Adrenergic receptors
a,B1 Adrenergic Agonism of a,B1
norepinephrine ↑HR, Vasoconstriction Hypotension
agonist Adrenergic receptors
Local & General Anesthetics
Arrythmia,
↓permiability of surgery,
Antiarrhythmic, Local Anasthesia,
lidocaine sodium, Block nerve Otorhinolaryngol
Local anesthetic Antiarrhythmia
impulse ogy,
Ophtalmology
↓permiability of Dentistry,
ultracaine Local anesthetic Local anesthesia sodium, Block nerve Pregnany
impulse women
General anesthetic
Catatonia, Block NMDA ↓CSF pressure,
ketamine (short acting, non-
Anasethsia, Amnesia receptor Surgery
inhalatory)
Denaturation of
ethyl alcohol Antiseptic Bactericidal Decontamination
protein
Ulcer, Burns,
bismuth Non-organic Astringent, Mucus formation,
Mucus
subcitrate astringent Antimicrobial mucus protection
inflammation
activated Adsorbent, Absorption of
Adsorbing Poisoning
charcoal Enterosorbent chemicals
Adsorbent, Absorption of
enterosgel Adsorbing Poisoning
Enterosorbent chemicals
Opioid & non-Opioid Analgesics
Severe pain,
Analgesic, ↓BP,
morphine Narcotic Analgesic Stimulation of opioid premedication,
sedative, hypnotic,
hydrochloride (Natural) receptors cough (in chest
antitussive
trauma)
timeperidine Narcotic Analgesic Analgesic, Stimulation of opioid Severe pain,
(Promedol) (Synthetic) spasmolytic receptors premedication
Neuroleptanalg
esia (fentanyl
Analgesic,
Narcotic Analgesic Stimulation of opioid +droperidol),
fentanyl antipsychotic,
(Synthetic) receptors Ataractanalgesi
tranquilizer
a (fentanyl
+diazepam)
Competitive
Reversing effect of
naloxone Opioid Antagonist antagonism of opioid Overdose
opioids
receptors
Headache, fever,
Non-narcotic
Analgesic, antipyretic, inflammatory
acetylsalycylic Analgesic, non- Non-selective cox
anti-inflammatory, diseases, ↓blood
acid (Asperin) selective cox inhibition
↓Protease activity circulation,
inhibitor, NSAID
Angina
Non-narcotic
Pain, fever,
diclofenac Analgesic, non- Analgesic, antipyretic, Non-selective cox
inflammatory
sodium selective cox anti-inflammatory inhibition
diseases
inhibitor, NSAID
Non-narcotic
paracetamol Analgesic, non- Non-selective cox
Analgesic, antipyretic Pain, fever
(acetaminophen) selective cox inhibition
inhibitor
, Non-narcotic
Pain, fever,
Analgesic, Analgesic, antipyretic, Selective cox
celecoxib inflammatory
selective cox anti-inflammatory inhibition
diseases
inhibitor, NSAID
Non-narcotic
Pain, fever,
Analgesic, Analgesic, antipyretic, Selective cox
meloxicam inflammatory
selective cox anti-inflammatory inhibition
diseases
inhibitor, NSAID
Non-narcotic
Pain, fever,
Analgesic, non- Analgeisic, antipyretic, Non-selective cox
ibuprofen inflammatory
selective cox anti-inflammatory inhibition
diseases
inhibitor, NSAID
Non-narcotic
Pain, fever,
Analgesic, non- Analgesic, antipyretic, Non-selective cox
naproxene inflammatory
slecetive cox anti-inflammatory inhibition
diseases
inhibitor, NSAID
codeine Narcotic Analgesic Stimulation of opioid Severe pain,
Analgeisc
phosphate (Natural) receptors premedication
Stimulation of opioid
Narcotic Analgesic receptors, reuptake Severe pain,
tramadol Analgesic
(Synthetic) of norepinephrine & premedication
serotonin
Neuroleptics, tranquilizers and sedative drugs
Blocks dopamine Psychosis,
receptors, a- hallucinations,
Typical Neuroleptic, adrenoreceptors, psychomotor
chlorpromazine
neuroleptic, antipsychotic, seretonin-receptors, agitations,
(Aminazin)
antiemetic antiemetic, sedative histamine-receptors nausea,
& M- vomiting,
cholinoreceptors premedication
Neuroleptanalg
Typical Neuroleptic, esia (fentanyl
Blocks dopamine
droperidol neuroleptic, antipsychotic, +droperidol),
receptors
antiemetic antiemetic, sedative nausesa,
vomiting
Neurosis,
anxiety, phobia,
Anxiolytic, hypnotic, Stimulate siezures,
Tranquilizer, sedative, benzodiazepine isnomnia,
diazepam
benzodiazepine myorelaxant, receptor of GABA premedication,
anticonvulsant receptor complex Ataractanalgesi
a (fentanyl
+diazepam)
Stimulate
Neurosis,
Daily tranquilizer, Anxyolytic, hypnotic, benzodiazepine
gidazepam anxiety,
benzodiazepine sedative receptor of GABA
insomnia
receptor complex
Hypnotic, antieplieptic and antiparkinson's drugs
Stimulate
Hypnotic, benzodiazepine Insomnia,
nitrazepam Hypnotic
benzodiazepine receptor of GABA neurosis
receptor complex
Inhibit GABA
sodium valproate Antieplieptic Antoeplieptic Epilepsy
tranferase
Stimulate barbiturate Insomnia,
Hypnotic,
phenobarbital Hypnotic receptor, GABA epilepsy,
barbiturate
activation neurosis
Antiparkinson's
levadopa/ Decarboxylation into Parkinson's
drug, dopamine Antiparkinsonism
carbidopa dopamine disease
precursor
Antieplieptic
Antiepyleptic,
(Carboxamide Blocks sodium (Na+) Epilepsy, bipolar
carbamozepine anticonvulsive,
derivative), channel disorder
analgesic adjuvant
Anticonvulsant
Psychostimulants, antidepressants, analeptics and nootropics
Phosphodiesterase
inhibitor
Asthenic
Psychostimulant, (accumulation of
caffeine sodium syndrome,
analeptic (xanthine Psychostimulating cAMP), Antagonism
benzoate carbon monoxide
derivative) of A1, A2A
poisoning
adenosine
receptors.
Stimulation of GABA
receptor, increase
Antidepressant nerve cell metabolic
piracetam Antidepressive Depression
(Nootropic) activity, improve
micro-circulation of
brain
Depression,
Antidepressive, anti- Non-selective
Antidepressant complex
amitriptyline histamine, anti- catecholamine
(Tricyclic) treatment of
cholinergic reuptake inhibition
schizophrenia
Antidepressive, Selective serotonin Bulemia,
fluoxetine Antidepressant
anorexogenic uptake inhibition depression, OCD
Hormonal, enzymatic and anti-enzymatic drugs
↑tissue sensitivity to
cathecholamines, T4 receptor
levothyroxine Hormonal drug Hypothyrodism
↑catabolism, ↑growth stimulation
&development
Insulin receptor
Hormonal drug, stimulation, transfer
insulin Hypoglycemic Diabetes mellitus
anti-diabetic of glucse from blood
to cells
Diabetes mellitus
Oral-hypoglycemic, ↑Insulin production, type 2 (if diet &
glibenclamide Hypoglycemic
anti-diabetic ↓gluconeogenesis, exercise not
↓glycogenolysis effective)
Anti-inflammatory, Inflammation,
PL-A2 inhibition,
anti-allergic, allergy,
prednisolone Glucocorticosteroid histamine release
immunosupressive, autoimmune
inhibition
anti-cancer diseases
Induction &
maintenance of
Hormonal drug, Oxytocin receptor
oxytocin Uterotonic labour, post
uterotonic stimulation
partum
hemorrhage
Anti-inflammatory, Inflammation,
PL-A2 inhibition,
methyl anti-allergic, allergy,
Glucocorticosteroid histamine release
prednisolone immunosupressive, autoimmune
inhibition
anti-cancer diseases
Anti-inflammatory, Inflammation,
PL-A2 inhibition,
anti-allergic, allergy,
dexamethasone Glucocorticosteroid histamine release
immunosupressive, autoimmune
inhibition
anti-cancer diseases
↓Resistance to Diabetes mellitus
Oral-hypoglycemic, insulin, type 2 (if diet &
metformin Hypoglycemic
anti-diabetic ↓gluconeogenesis, exercise not
↓glycogenolysis effective)
Anti-inflammatory, Anti-inflammatory, Bronchial
budesonide Glucocorticosteroid
anti-allergic anti-allergic asthma
Anti-inflammatory, Inflammation,
PL-A2 inhibition,
mometasone anti-allergic, allergy,
Glucocorticosteroid histamine release
furoate immunosupressive, autoimmune
inhibition
anti-cancer diseases
Useful links:
Drug Pharm Group Pharm Effect MoA Indication Side Effects Contraindication https://www.youtube.com/watch?v=0hVaO1rlXus&list=PLekhl8ZQS2PahYNzzQow72dLyLAXj2dDJ
Cholinergic drugs https://www.youtube.com/channel/UCIzOHtZa0iOH49ez1O5mReQ
Bronchospasm,
Parasympatholytic, Mydriasis, Direct antagonist of Muscarine
atropine sulphate Direct-acting M- Tachycardia, ↓Gland muscarinic ACh poisoning,
Cholinoblocker secretion, etc receptor Fundoscopy,
Cramps
Parasympathomim Direct agonism of
pilocarpine Miosis, Bracychardia,
etic, Direct-acting muscarining ACh Glaucoma
hydrochloride etc
M-Cholinomimetic receptor
Reversible
Cholinesterase
inhibitor, Non-
Anticholinesterase, Forms covalent Myasthenia
neostigmine selective
Bradycardia, Miosis, bond with gravis,
(Proserine) Cholinergic
etc acetylcholinesterase Glaucoma
Agonist,
Parasympathomim
etic
Non-selective
Binding to
direct-acting Short term
suxamethonium cholinergic receptors
cholinergic Myorelaxation surgery, electric
(Dithyline) and preventing
Antagonist, shock therapy
further stimulation
Myorelaxant
tiotropium Blocking muscarinic
Parasympatholytic, Asthma, Chronic
bromide Bronchodialation (M3) acetycholine
M-cholinoblocker bronchitis
(Ipratropium) receptor
Blocking
Parasympatholytic, ↓Gastric secretion, muscarininc (M1)
pirenzepine Peptic ulcer
M-Cholinoblocker ↓Muscle spasm acetycholine
receptor
Adrenergic drugs
Sympathetic effects,
↑HR, ↑BP,
Sympathomimetic,
Vasoconstriction, Anaphylaxis,
epinephrine Direct-acting Non- Agonism of a & B
↑Glycogenolysis, Cardiac arrest,
(Adrenaline) Selective adrenergic receptors
↑Gluconeogenesis, Bronchospasm
Adronergic Agonist
Bronchodilation,
Mydriasis
Nasal
phenylephrine Selective a1- Vasoconstriction, Agonism of a1 congestion,
(Mesaton) Adrenergic Agonist Mydriasis, ↑BP Adrenergic receptors Postsurgical
hypotension
Non-selective Beta
Adrenergic blocker, Hypertension,
propanolol ↓HR, Hypotensive, Antagonism of B
Antihypertensive, Arrhythmia,
(Anapril) Antianginal adrenergic receptor
Antiarrhythmic, Angina
Antianginal
B1-Adrenergic
Antagonism of B Hypertension,
metroprolol blocker, ↓HR, Hypotensive
adrenergic receptor Arrhythmia
Antihypertensive
B1-Adrenergic Agonism of B1 Cardiac
dobutamine Inotropic effect
agonist Adrenergic receptor decompensation
albuterol B2-Adrenergic Agonism of B2 Bronchospasm,
Bronchodilation
(Salbutamol) agonist Adrenergic receptor Asthma
Blocking
Adrenoblocker, ↓BP, Bradycardia, catecholamine
reserpine Hypertension
Antihypertensive ↓BP transport to vesicles
in synapses
B1-Adrenoblocker, Antagonist of B1-
bisoprolol ↓HR, ↓BP Hypertension
Antihypertensive Adrenergic receptor
Antagonism of B,a1-
carvedilol B,a1-Adrenoblocker ↓HR, Miosis, ↓BP Hypertension
Adrenergic receptors
Antagonism of a1-
doxazosin a1-Adrenoblocker Vasodilation, ↓BP Hypertension
Adrenergic receptor
Sympatholytic, a2- Agonism of a2-
methyldopa ↓BP, ↓Norepinephrine Hypertension
Adrenergic Agonist Adrenergic receptors
a,B1 Adrenergic Agonism of a,B1
norepinephrine ↑HR, Vasoconstriction Hypotension
agonist Adrenergic receptors
Local & General Anesthetics
Arrythmia,
↓permiability of surgery,
Antiarrhythmic, Local Anasthesia,
lidocaine sodium, Block nerve Otorhinolaryngol
Local anesthetic Antiarrhythmia
impulse ogy,
Ophtalmology
↓permiability of Dentistry,
ultracaine Local anesthetic Local anesthesia sodium, Block nerve Pregnany
impulse women
General anesthetic
Catatonia, Block NMDA ↓CSF pressure,
ketamine (short acting, non-
Anasethsia, Amnesia receptor Surgery
inhalatory)
Denaturation of
ethyl alcohol Antiseptic Bactericidal Decontamination
protein
Ulcer, Burns,
bismuth Non-organic Astringent, Mucus formation,
Mucus
subcitrate astringent Antimicrobial mucus protection
inflammation
activated Adsorbent, Absorption of
Adsorbing Poisoning
charcoal Enterosorbent chemicals
Adsorbent, Absorption of
enterosgel Adsorbing Poisoning
Enterosorbent chemicals
Opioid & non-Opioid Analgesics
Severe pain,
Analgesic, ↓BP,
morphine Narcotic Analgesic Stimulation of opioid premedication,
sedative, hypnotic,
hydrochloride (Natural) receptors cough (in chest
antitussive
trauma)
timeperidine Narcotic Analgesic Analgesic, Stimulation of opioid Severe pain,
(Promedol) (Synthetic) spasmolytic receptors premedication
Neuroleptanalg
esia (fentanyl
Analgesic,
Narcotic Analgesic Stimulation of opioid +droperidol),
fentanyl antipsychotic,
(Synthetic) receptors Ataractanalgesi
tranquilizer
a (fentanyl
+diazepam)
Competitive
Reversing effect of
naloxone Opioid Antagonist antagonism of opioid Overdose
opioids
receptors
Headache, fever,
Non-narcotic
Analgesic, antipyretic, inflammatory
acetylsalycylic Analgesic, non- Non-selective cox
anti-inflammatory, diseases, ↓blood
acid (Asperin) selective cox inhibition
↓Protease activity circulation,
inhibitor, NSAID
Angina
Non-narcotic
Pain, fever,
diclofenac Analgesic, non- Analgesic, antipyretic, Non-selective cox
inflammatory
sodium selective cox anti-inflammatory inhibition
diseases
inhibitor, NSAID
Non-narcotic
paracetamol Analgesic, non- Non-selective cox
Analgesic, antipyretic Pain, fever
(acetaminophen) selective cox inhibition
inhibitor
, Non-narcotic
Pain, fever,
Analgesic, Analgesic, antipyretic, Selective cox
celecoxib inflammatory
selective cox anti-inflammatory inhibition
diseases
inhibitor, NSAID
Non-narcotic
Pain, fever,
Analgesic, Analgesic, antipyretic, Selective cox
meloxicam inflammatory
selective cox anti-inflammatory inhibition
diseases
inhibitor, NSAID
Non-narcotic
Pain, fever,
Analgesic, non- Analgeisic, antipyretic, Non-selective cox
ibuprofen inflammatory
selective cox anti-inflammatory inhibition
diseases
inhibitor, NSAID
Non-narcotic
Pain, fever,
Analgesic, non- Analgesic, antipyretic, Non-selective cox
naproxene inflammatory
slecetive cox anti-inflammatory inhibition
diseases
inhibitor, NSAID
codeine Narcotic Analgesic Stimulation of opioid Severe pain,
Analgeisc
phosphate (Natural) receptors premedication
Stimulation of opioid
Narcotic Analgesic receptors, reuptake Severe pain,
tramadol Analgesic
(Synthetic) of norepinephrine & premedication
serotonin
Neuroleptics, tranquilizers and sedative drugs
Blocks dopamine Psychosis,
receptors, a- hallucinations,
Typical Neuroleptic, adrenoreceptors, psychomotor
chlorpromazine
neuroleptic, antipsychotic, seretonin-receptors, agitations,
(Aminazin)
antiemetic antiemetic, sedative histamine-receptors nausea,
& M- vomiting,
cholinoreceptors premedication
Neuroleptanalg
Typical Neuroleptic, esia (fentanyl
Blocks dopamine
droperidol neuroleptic, antipsychotic, +droperidol),
receptors
antiemetic antiemetic, sedative nausesa,
vomiting
Neurosis,
anxiety, phobia,
Anxiolytic, hypnotic, Stimulate siezures,
Tranquilizer, sedative, benzodiazepine isnomnia,
diazepam
benzodiazepine myorelaxant, receptor of GABA premedication,
anticonvulsant receptor complex Ataractanalgesi
a (fentanyl
+diazepam)
Stimulate
Neurosis,
Daily tranquilizer, Anxyolytic, hypnotic, benzodiazepine
gidazepam anxiety,
benzodiazepine sedative receptor of GABA
insomnia
receptor complex
Hypnotic, antieplieptic and antiparkinson's drugs
Stimulate
Hypnotic, benzodiazepine Insomnia,
nitrazepam Hypnotic
benzodiazepine receptor of GABA neurosis
receptor complex
Inhibit GABA
sodium valproate Antieplieptic Antoeplieptic Epilepsy
tranferase
Stimulate barbiturate Insomnia,
Hypnotic,
phenobarbital Hypnotic receptor, GABA epilepsy,
barbiturate
activation neurosis
Antiparkinson's
levadopa/ Decarboxylation into Parkinson's
drug, dopamine Antiparkinsonism
carbidopa dopamine disease
precursor
Antieplieptic
Antiepyleptic,
(Carboxamide Blocks sodium (Na+) Epilepsy, bipolar
carbamozepine anticonvulsive,
derivative), channel disorder
analgesic adjuvant
Anticonvulsant
Psychostimulants, antidepressants, analeptics and nootropics
Phosphodiesterase
inhibitor
Asthenic
Psychostimulant, (accumulation of
caffeine sodium syndrome,
analeptic (xanthine Psychostimulating cAMP), Antagonism
benzoate carbon monoxide
derivative) of A1, A2A
poisoning
adenosine
receptors.
Stimulation of GABA
receptor, increase
Antidepressant nerve cell metabolic
piracetam Antidepressive Depression
(Nootropic) activity, improve
micro-circulation of
brain
Depression,
Antidepressive, anti- Non-selective
Antidepressant complex
amitriptyline histamine, anti- catecholamine
(Tricyclic) treatment of
cholinergic reuptake inhibition
schizophrenia
Antidepressive, Selective serotonin Bulemia,
fluoxetine Antidepressant
anorexogenic uptake inhibition depression, OCD
Hormonal, enzymatic and anti-enzymatic drugs
↑tissue sensitivity to
cathecholamines, T4 receptor
levothyroxine Hormonal drug Hypothyrodism
↑catabolism, ↑growth stimulation
&development
Insulin receptor
Hormonal drug, stimulation, transfer
insulin Hypoglycemic Diabetes mellitus
anti-diabetic of glucse from blood
to cells
Diabetes mellitus
Oral-hypoglycemic, ↑Insulin production, type 2 (if diet &
glibenclamide Hypoglycemic
anti-diabetic ↓gluconeogenesis, exercise not
↓glycogenolysis effective)
Anti-inflammatory, Inflammation,
PL-A2 inhibition,
anti-allergic, allergy,
prednisolone Glucocorticosteroid histamine release
immunosupressive, autoimmune
inhibition
anti-cancer diseases
Induction &
maintenance of
Hormonal drug, Oxytocin receptor
oxytocin Uterotonic labour, post
uterotonic stimulation
partum
hemorrhage
Anti-inflammatory, Inflammation,
PL-A2 inhibition,
methyl anti-allergic, allergy,
Glucocorticosteroid histamine release
prednisolone immunosupressive, autoimmune
inhibition
anti-cancer diseases
Anti-inflammatory, Inflammation,
PL-A2 inhibition,
anti-allergic, allergy,
dexamethasone Glucocorticosteroid histamine release
immunosupressive, autoimmune
inhibition
anti-cancer diseases
↓Resistance to Diabetes mellitus
Oral-hypoglycemic, insulin, type 2 (if diet &
metformin Hypoglycemic
anti-diabetic ↓gluconeogenesis, exercise not
↓glycogenolysis effective)
Anti-inflammatory, Anti-inflammatory, Bronchial
budesonide Glucocorticosteroid
anti-allergic anti-allergic asthma
Anti-inflammatory, Inflammation,
PL-A2 inhibition,
mometasone anti-allergic, allergy,
Glucocorticosteroid histamine release
furoate immunosupressive, autoimmune
inhibition
anti-cancer diseases
