TIETZ CLINICAL CHEMISTRY MOCK EXAM
AND STUDY MATERIAL WITH CASE-BASED LAB
SCENARIOS AND ANALYTICAL PRACTICE
◉ 2. The study of the genetic variation between individuals in their
ability to metabolize drugs is referred to as: a. pharmacogenetics. b.
molecular diagnostics. c. clinical chemistry. d. epidemiology.
Answer: Answer: a. pharmacogenetics.
◉ 3. When a practitioner in clinical chemistry has an inappropriate
personal relationship with a commercial supplier of medical
supplies and chemistry analyzers, there may be a potential issue
with: a. publication development. b. confidentiality. c. selection of
treatment. d. conflict of interest.
Answer: Answer: d. conflict of interest.
◉ 4. "Molecular testing" involves the clinical analysis of: a. atoms
and molecules. b. nucleic acids. c. cellular components of blood. d.
the physical structure of compounds.
Answer: Answer: b. nucleic acids.
◉ 5. Which one of the following is not considered an ethical issue
facing a clinical laboratorian? a. Allocation of resources b. Conflicts
,of interest c. Discussion of one's salary d. Maintenance of
confidentiality
Answer: Answer: c. Discussion of one's salary.
◉ Question
Answer: Answer
◉ 1. The type of error that occurs when an analytical method is
nonspecific for an analyte and is actually considered to be a type of
bias is: a. systematic error. b. nonsystematic error. c. random error. d.
true error.
Answer: Answer: a. systematic error.
◉ 2. The statistical analysis commonly applied when the results of
analytical method comparison that involves a plot of paired
observations (one from the established method and the other from
the new method) are assessed is: a. uncertainty analysis. b.
traceability analysis. c. regression analysis. d. difference analysis.
Answer: Answer: c. regression analysis.
◉ 3. In the selection of a new method, the first step in selecting a
candidate method is the determination of: a. reliability. b. total
allowable error. c. specifics of the assay including reagent stability. d.
what is necessary clinically from a laboratory test.
Answer: Answer: b. total allowable error.
,◉ 4. To categorize whether a systematic error is either constant or
proportional, one must assume and test for: a. randomness. b.
linearity. c. precision. d. accuracy.
Answer: Answer: b. linearity.
◉ 5. Which one of the following, when stated as an interval around a
reported laboratory result, will specify the location of the true value
with a given probability? a. Traceability b. Coefficient of variation c.
Trueness d. Uncertainty
Answer: Answer: d. Uncertainty.
◉ 6. The closeness of agreement between independent results or
measurements obtained under specific conditions is: a. linearity. b.
precision. c. accuracy. d. specificity.
Answer: Answer: b. precision.
◉ 7. Analytical specificity is: a. the ability of an assay procedure to
determine the concentration of a target analyte in the presence of
interfering substances in the sample matrix. b. the detection limit of
a method. c. the ability of an analytical method to assess small
variations in the concentration of analyte. d. the analyte
concentration range over which measurements are within the
declared tolerances for imprecision and bias of the method.
, Answer: Answer: a. the ability of an assay procedure to determine
the concentration of a target analyte in the presence of interfering
substances in the sample matrix.
◉ 8. In a regression analysis that compares results of two methods,
the y-intercept is calculated to be 2.0 and the slope is 3. This
indicates a(n): a. calibration error. b. uncertainty. c. systematic
difference. d. interference in one method.
Answer: Answer: c. systematic difference.
◉ 9. A type of regression analysis that is used to estimate slope and
intercept and that is acceptant to outlier values in the methods and
does not require assumption of a Gaussian distribution is: a.
weighted Deming regression analysis. b. ordinary least-squares
regression analysis. c. linear regression analysis. d. nonparametric
regression analysis.
Answer: Answer: a. weighted Deming regression analysis.
◉ 10. In a method comparison analysis, the lowest value of an
analyte that significantly exceeds the measurement of a blank
sample is referred to as the: a. limit of detection of a method. b.
analytical sensitivity. c. analytical specificity. d. basic error of a
method.
Answer: Answer: a. limit of detection of a method.
AND STUDY MATERIAL WITH CASE-BASED LAB
SCENARIOS AND ANALYTICAL PRACTICE
◉ 2. The study of the genetic variation between individuals in their
ability to metabolize drugs is referred to as: a. pharmacogenetics. b.
molecular diagnostics. c. clinical chemistry. d. epidemiology.
Answer: Answer: a. pharmacogenetics.
◉ 3. When a practitioner in clinical chemistry has an inappropriate
personal relationship with a commercial supplier of medical
supplies and chemistry analyzers, there may be a potential issue
with: a. publication development. b. confidentiality. c. selection of
treatment. d. conflict of interest.
Answer: Answer: d. conflict of interest.
◉ 4. "Molecular testing" involves the clinical analysis of: a. atoms
and molecules. b. nucleic acids. c. cellular components of blood. d.
the physical structure of compounds.
Answer: Answer: b. nucleic acids.
◉ 5. Which one of the following is not considered an ethical issue
facing a clinical laboratorian? a. Allocation of resources b. Conflicts
,of interest c. Discussion of one's salary d. Maintenance of
confidentiality
Answer: Answer: c. Discussion of one's salary.
◉ Question
Answer: Answer
◉ 1. The type of error that occurs when an analytical method is
nonspecific for an analyte and is actually considered to be a type of
bias is: a. systematic error. b. nonsystematic error. c. random error. d.
true error.
Answer: Answer: a. systematic error.
◉ 2. The statistical analysis commonly applied when the results of
analytical method comparison that involves a plot of paired
observations (one from the established method and the other from
the new method) are assessed is: a. uncertainty analysis. b.
traceability analysis. c. regression analysis. d. difference analysis.
Answer: Answer: c. regression analysis.
◉ 3. In the selection of a new method, the first step in selecting a
candidate method is the determination of: a. reliability. b. total
allowable error. c. specifics of the assay including reagent stability. d.
what is necessary clinically from a laboratory test.
Answer: Answer: b. total allowable error.
,◉ 4. To categorize whether a systematic error is either constant or
proportional, one must assume and test for: a. randomness. b.
linearity. c. precision. d. accuracy.
Answer: Answer: b. linearity.
◉ 5. Which one of the following, when stated as an interval around a
reported laboratory result, will specify the location of the true value
with a given probability? a. Traceability b. Coefficient of variation c.
Trueness d. Uncertainty
Answer: Answer: d. Uncertainty.
◉ 6. The closeness of agreement between independent results or
measurements obtained under specific conditions is: a. linearity. b.
precision. c. accuracy. d. specificity.
Answer: Answer: b. precision.
◉ 7. Analytical specificity is: a. the ability of an assay procedure to
determine the concentration of a target analyte in the presence of
interfering substances in the sample matrix. b. the detection limit of
a method. c. the ability of an analytical method to assess small
variations in the concentration of analyte. d. the analyte
concentration range over which measurements are within the
declared tolerances for imprecision and bias of the method.
, Answer: Answer: a. the ability of an assay procedure to determine
the concentration of a target analyte in the presence of interfering
substances in the sample matrix.
◉ 8. In a regression analysis that compares results of two methods,
the y-intercept is calculated to be 2.0 and the slope is 3. This
indicates a(n): a. calibration error. b. uncertainty. c. systematic
difference. d. interference in one method.
Answer: Answer: c. systematic difference.
◉ 9. A type of regression analysis that is used to estimate slope and
intercept and that is acceptant to outlier values in the methods and
does not require assumption of a Gaussian distribution is: a.
weighted Deming regression analysis. b. ordinary least-squares
regression analysis. c. linear regression analysis. d. nonparametric
regression analysis.
Answer: Answer: a. weighted Deming regression analysis.
◉ 10. In a method comparison analysis, the lowest value of an
analyte that significantly exceeds the measurement of a blank
sample is referred to as the: a. limit of detection of a method. b.
analytical sensitivity. c. analytical specificity. d. basic error of a
method.
Answer: Answer: a. limit of detection of a method.
