MMSC 433 exam 1 EXAM Questions with 100% Correct Answers | Verified |
Updated (Actual Exam) LATEST VERSION!! EXAM Questions with 100%
Correct
iron absorption - (ANSWER)-ferric iron is taken in from diet
-ferric iron is reduced by duodenal cytochrome B to become ferrous iron
-ferrous iron is absorbed into enterocytes by DMT 1
-absorbed iron is stored as ferritin, or sent into portal hepatic circulation and carried by transferrin to
developing RBCs
transferrin - (ANSWER)plasma carrier protein for ferrous iron
high iron level regulation - (ANSWER)-hepcidin is released from hepatocytes
-ferroportin is inactivated, leading to decreased iron being transported into circulation
low iron level regulation - (ANSWER)-hepcidin is down regulated by hepatocytes
-ferroportin becomes activated and transports iron out of the enterocytes and into circulation
dietary iron sources - (ANSWER)red meat, legumes, dark leafy vegetables, whole grains
ferrous iron - (ANSWER)the form of iron that is able to be utilized in the body for developing red cells
prussian blue stain - (ANSWER)stain that is used to identify iron in tissues and bone marrow
thomas plot - (ANSWER)a chart that is used to compare soluble transferrin receptors/ log ferritin to
hemoglobin concentration of reticulocytes to identify the iron status of the patient
-iron status is used to correlate to certain diseases/ anemias
stage 1 iron deficiency (progressive loss of storage iron) - (ANSWER)-asymptomatic
,MMSC 433 exam 1 EXAM Questions with 100% Correct Answers | Verified |
Updated (Actual Exam) LATEST VERSION!! EXAM Questions with 100%
Correct
-RBCs develop normally
-*serum ferritin low*
stage 2 iron deficiency (exhaustion of iron storage pool) - (ANSWER)-subclinical symptoms
-hemoglobin in retics is decreased, *hemogram appears normal still*
-iron deficiency erythropoiesis is occurring
-hepcidin decreased
-serum iron and ferritin decreased
-RDW, TIBC and sTRs increased
-prussian blue stain of BM is negative for iron
stage 3 iron deficiency (frank anemia) - (ANSWER)-patient exhibits fatigue, weakness, pallor, glossitis,
koilonychia and pica
-*H/H decreased*
-*hypochromic/ microcytic anemia*
-FEP, TIBC and sTR increased
-ferritin, hepcidin and serum iron decreased
sideroblastic anemia - (ANSWER)-iron deposits in the mitochondria of erythroblast cells in the bone
marrow interfere with biosynthesis of heme
-caused by genetic inheritance of drugs/ bone marrow toxins (*lead*, antibiotics, chemotherapeutics)
-*ringed sideroblasts* are highly indicative of the disease
-basophillic stippling is common in lead poisoning
-normocytic normochromic cells
, MMSC 433 exam 1 EXAM Questions with 100% Correct Answers | Verified |
Updated (Actual Exam) LATEST VERSION!! EXAM Questions with 100%
Correct
iron deficiency anemia (IDA) - (ANSWER)-caused by inadequate intake, increased need or malabsorption
of iron, poor diet or chronic blood loss
-symptoms: fatigue, weakness, pallor, spooning of the nails (koilonychia) and pica
-*H/H decreased*
-microcytic, hypochromic cells
-marked poikilocytosis (target cells, spherocytes, tear drop cells and schistocytes)
-FEP, sTR and TIBC increased
-ferritin, hepcidin and serum iron decreased
anemia of chronic inflammation - (ANSWER)-anemia occurring secondary to underlying condition
(chronic inflammatory disease, chronic infection or malignancy) that causes release of cell products
-hepcidin, lactoferrin and inflammatory cytokines cause decreased iron status and anemia
-low Hgb
-*low TIBC* (hepcidin is increased due to acute phase reaction)
-normocytic normochromic anemia
-serum iron decreased
-ferritin (acute phase reactant) and FEP increased
hereditary hemochromatosis (HH) - (ANSWER)-inheritance of mutated HFE gene inhibits production of
hepcidin, leading to constant activation of ferroportin
-increased levels of iron in circulation are exposed to oxygen and produce damaging superoxide ions
-symptoms: begin between 30-40, iron deposits on organs (pancreas), bronzed diabetes, cell death,
release of lysosomal enzymes
-increased serum ferritin and transferrin saturation
-genetic testing reveals mutated HFE gene
Updated (Actual Exam) LATEST VERSION!! EXAM Questions with 100%
Correct
iron absorption - (ANSWER)-ferric iron is taken in from diet
-ferric iron is reduced by duodenal cytochrome B to become ferrous iron
-ferrous iron is absorbed into enterocytes by DMT 1
-absorbed iron is stored as ferritin, or sent into portal hepatic circulation and carried by transferrin to
developing RBCs
transferrin - (ANSWER)plasma carrier protein for ferrous iron
high iron level regulation - (ANSWER)-hepcidin is released from hepatocytes
-ferroportin is inactivated, leading to decreased iron being transported into circulation
low iron level regulation - (ANSWER)-hepcidin is down regulated by hepatocytes
-ferroportin becomes activated and transports iron out of the enterocytes and into circulation
dietary iron sources - (ANSWER)red meat, legumes, dark leafy vegetables, whole grains
ferrous iron - (ANSWER)the form of iron that is able to be utilized in the body for developing red cells
prussian blue stain - (ANSWER)stain that is used to identify iron in tissues and bone marrow
thomas plot - (ANSWER)a chart that is used to compare soluble transferrin receptors/ log ferritin to
hemoglobin concentration of reticulocytes to identify the iron status of the patient
-iron status is used to correlate to certain diseases/ anemias
stage 1 iron deficiency (progressive loss of storage iron) - (ANSWER)-asymptomatic
,MMSC 433 exam 1 EXAM Questions with 100% Correct Answers | Verified |
Updated (Actual Exam) LATEST VERSION!! EXAM Questions with 100%
Correct
-RBCs develop normally
-*serum ferritin low*
stage 2 iron deficiency (exhaustion of iron storage pool) - (ANSWER)-subclinical symptoms
-hemoglobin in retics is decreased, *hemogram appears normal still*
-iron deficiency erythropoiesis is occurring
-hepcidin decreased
-serum iron and ferritin decreased
-RDW, TIBC and sTRs increased
-prussian blue stain of BM is negative for iron
stage 3 iron deficiency (frank anemia) - (ANSWER)-patient exhibits fatigue, weakness, pallor, glossitis,
koilonychia and pica
-*H/H decreased*
-*hypochromic/ microcytic anemia*
-FEP, TIBC and sTR increased
-ferritin, hepcidin and serum iron decreased
sideroblastic anemia - (ANSWER)-iron deposits in the mitochondria of erythroblast cells in the bone
marrow interfere with biosynthesis of heme
-caused by genetic inheritance of drugs/ bone marrow toxins (*lead*, antibiotics, chemotherapeutics)
-*ringed sideroblasts* are highly indicative of the disease
-basophillic stippling is common in lead poisoning
-normocytic normochromic cells
, MMSC 433 exam 1 EXAM Questions with 100% Correct Answers | Verified |
Updated (Actual Exam) LATEST VERSION!! EXAM Questions with 100%
Correct
iron deficiency anemia (IDA) - (ANSWER)-caused by inadequate intake, increased need or malabsorption
of iron, poor diet or chronic blood loss
-symptoms: fatigue, weakness, pallor, spooning of the nails (koilonychia) and pica
-*H/H decreased*
-microcytic, hypochromic cells
-marked poikilocytosis (target cells, spherocytes, tear drop cells and schistocytes)
-FEP, sTR and TIBC increased
-ferritin, hepcidin and serum iron decreased
anemia of chronic inflammation - (ANSWER)-anemia occurring secondary to underlying condition
(chronic inflammatory disease, chronic infection or malignancy) that causes release of cell products
-hepcidin, lactoferrin and inflammatory cytokines cause decreased iron status and anemia
-low Hgb
-*low TIBC* (hepcidin is increased due to acute phase reaction)
-normocytic normochromic anemia
-serum iron decreased
-ferritin (acute phase reactant) and FEP increased
hereditary hemochromatosis (HH) - (ANSWER)-inheritance of mutated HFE gene inhibits production of
hepcidin, leading to constant activation of ferroportin
-increased levels of iron in circulation are exposed to oxygen and produce damaging superoxide ions
-symptoms: begin between 30-40, iron deposits on organs (pancreas), bronzed diabetes, cell death,
release of lysosomal enzymes
-increased serum ferritin and transferrin saturation
-genetic testing reveals mutated HFE gene
