COMSAE PHASE 2 EXAM QUESTIONS & ANSWERS 2026-2027 | COMPLETE COMLEX STUDY G… EXAM
P R O F E S S I O N A L P R A C T I C E M AT E R I A L S
COMSAE Phase 2 Exam
Questions & Answers 2026-2027
| Complete COMLEX Study Guide
| Verified Practice Test
(Rationales)
Verified Answers Exam Ready With Rationales
105 QUESTIONS
DOCUMENT OVERVIEW
This document provides 105 verified questions with correct answers and detailed rationales, focusing on
medical knowledge essential for the COMLEX exam. Each question is designed to enhance understanding
through comprehensive explanations, making it an invaluable resource for exam preparation and review.
Students can utilize this guide for effective study, certification readiness, and to reinforce their clinical
reasoning skills.
CONTENTS
01 Musculoskeletal Disorders Q1–Q7
02 Infectious Diseases Q8–Q14
03 Gastrointestinal Conditions Q15–Q21
04 Dermatological Conditions Q22–Q28
05 Neurological Disorders Q29–Q35
06 Pediatrics Q36–Q40
Page 1
, 07 Endocrine and Metabolic Disorders Q41–Q46
08 Obstetrics and Gynecology Q47–Q51
09 Additional Questions Q52–Q105
E XA M Q U EST I O N S
Q1 QUESTION 1 OF 105
Exquisite tenderness at apex of sacrum that is worsened by sitting
CORRECT ANSWER
sacrococcygeal strain
RATIONALE
Sacrococcygeal strain results in localized tenderness at the apex of the sacrum due to overstretching or injury to the ligaments and
muscles surrounding the coccyx, exacerbated by pressure from sitting. This condition often presents with increased discomfort when
weight is applied to the area, highlighting the importance of proper posture and body mechanics in prevention and management.
Q2 QUESTION 2 OF 105
AAA for eldery patient with COPD
CORRECT ANSWER
endovascular repair
RATIONALE
Endovascular repair minimizes surgical trauma and shortens recovery time, making it particularly advantageous for elderly patients with
comorbidities like COPD, who may not tolerate open surgery well. This approach leverages catheter-based techniques to address
abdominal aortic aneurysms with reduced risk of complications associated with traditional methods.
Q3 QUESTION 3 OF 105
College football player develops functional scoliosis due to
CORRECT ANSWER
developmental response on dominant hand
Page 2
, RATIONALE
Functional scoliosis often results from uneven muscle development and postural adaptations related to dominant hand use, leading to
asymmetrical loading of the spine. This imbalance causes a compensatory curve in the spine, which is non-structural and can be
improved with corrective measures.
Q4 QUESTION 4 OF 105
Patellofemoral pain syndrome is treated with ___ if hamstrings are hypertonic
CORRECT ANSWER
myofascial release of hamstring
RATIONALE
Myofascial release of the hamstring addresses hypertonicity by reducing muscle tension and restoring optimal length-tension
relationships, which can alleviate strain on the patellofemoral joint. This technique promotes improved flexibility and function, essential
for mitigating patellofemoral pain syndrome.
Q5 QUESTION 5 OF 105
Psoas syndrome starts at what vertebra
CORRECT ANSWER
L1
RATIONALE
Psoas syndrome originates from irritation or dysfunction at the L1 vertebra, which affects the psoas major muscle's position and
function, leading to characteristic pain patterns. This condition highlights the interconnectedness of lumbar vertebral health and
musculoskeletal function.
Q6 QUESTION 6 OF 105
What OMM technique would help treat Bell's Palsy
CORRECT ANSWER
temporal rocking (CN VII exits through temporal bone)
RATIONALE
Temporal rocking facilitates cranial mobility and specifically addresses the dysfunction of cranial nerve VII, which exits through the
temporal bone, thereby potentially alleviating symptoms associated with Bell's Palsy. This technique enhances the circulation and
function of the facial nerve by promoting lymphatic drainage and reducing cranial tension.
Page 3
, Q7 QUESTION 7 OF 105
Anterior shoulder pain with limited supination
CORRECT ANSWER
biceps tendonitis
RATIONALE
Biceps tendonitis is characterized by inflammation of the biceps tendon at the shoulder, often resulting in anterior shoulder pain and
restricted supination due to pain and weakness in the biceps muscle's function. Understanding the biomechanics of shoulder
movement reveals how tendonitis can impair both motion and strength, particularly during supination.
Q8 QUESTION 8 OF 105
HIV patient with white opaque patches with hemorrhagic necrosis of retina
CORRECT ANSWER
CMV retinitis
RATIONALE
Cytomegalovirus (CMV) retinitis is characterized by retinal necrosis and the presence of white, opaque patches, particularly in
immunocompromised individuals such as those with HIV. This condition results from the reactivation of latent CMV, leading to
significant vision loss if untreated.
Q9 QUESTION 9 OF 105
Teenager is given amoxicillin which causes rash and tests negative for heterophile antibody test
CORRECT ANSWER
CMV
RATIONALE
Amoxicillin can induce a rash in individuals with Epstein-Barr virus (EBV) infection, but a negative heterophile antibody test suggests an
alternative viral etiology. Cytomegalovirus (CMV) remains a plausible cause of mononucleosis-like symptoms without the associated
heterophile antibodies.
Q10 QUESTION 10 OF 105
Page 4
P R O F E S S I O N A L P R A C T I C E M AT E R I A L S
COMSAE Phase 2 Exam
Questions & Answers 2026-2027
| Complete COMLEX Study Guide
| Verified Practice Test
(Rationales)
Verified Answers Exam Ready With Rationales
105 QUESTIONS
DOCUMENT OVERVIEW
This document provides 105 verified questions with correct answers and detailed rationales, focusing on
medical knowledge essential for the COMLEX exam. Each question is designed to enhance understanding
through comprehensive explanations, making it an invaluable resource for exam preparation and review.
Students can utilize this guide for effective study, certification readiness, and to reinforce their clinical
reasoning skills.
CONTENTS
01 Musculoskeletal Disorders Q1–Q7
02 Infectious Diseases Q8–Q14
03 Gastrointestinal Conditions Q15–Q21
04 Dermatological Conditions Q22–Q28
05 Neurological Disorders Q29–Q35
06 Pediatrics Q36–Q40
Page 1
, 07 Endocrine and Metabolic Disorders Q41–Q46
08 Obstetrics and Gynecology Q47–Q51
09 Additional Questions Q52–Q105
E XA M Q U EST I O N S
Q1 QUESTION 1 OF 105
Exquisite tenderness at apex of sacrum that is worsened by sitting
CORRECT ANSWER
sacrococcygeal strain
RATIONALE
Sacrococcygeal strain results in localized tenderness at the apex of the sacrum due to overstretching or injury to the ligaments and
muscles surrounding the coccyx, exacerbated by pressure from sitting. This condition often presents with increased discomfort when
weight is applied to the area, highlighting the importance of proper posture and body mechanics in prevention and management.
Q2 QUESTION 2 OF 105
AAA for eldery patient with COPD
CORRECT ANSWER
endovascular repair
RATIONALE
Endovascular repair minimizes surgical trauma and shortens recovery time, making it particularly advantageous for elderly patients with
comorbidities like COPD, who may not tolerate open surgery well. This approach leverages catheter-based techniques to address
abdominal aortic aneurysms with reduced risk of complications associated with traditional methods.
Q3 QUESTION 3 OF 105
College football player develops functional scoliosis due to
CORRECT ANSWER
developmental response on dominant hand
Page 2
, RATIONALE
Functional scoliosis often results from uneven muscle development and postural adaptations related to dominant hand use, leading to
asymmetrical loading of the spine. This imbalance causes a compensatory curve in the spine, which is non-structural and can be
improved with corrective measures.
Q4 QUESTION 4 OF 105
Patellofemoral pain syndrome is treated with ___ if hamstrings are hypertonic
CORRECT ANSWER
myofascial release of hamstring
RATIONALE
Myofascial release of the hamstring addresses hypertonicity by reducing muscle tension and restoring optimal length-tension
relationships, which can alleviate strain on the patellofemoral joint. This technique promotes improved flexibility and function, essential
for mitigating patellofemoral pain syndrome.
Q5 QUESTION 5 OF 105
Psoas syndrome starts at what vertebra
CORRECT ANSWER
L1
RATIONALE
Psoas syndrome originates from irritation or dysfunction at the L1 vertebra, which affects the psoas major muscle's position and
function, leading to characteristic pain patterns. This condition highlights the interconnectedness of lumbar vertebral health and
musculoskeletal function.
Q6 QUESTION 6 OF 105
What OMM technique would help treat Bell's Palsy
CORRECT ANSWER
temporal rocking (CN VII exits through temporal bone)
RATIONALE
Temporal rocking facilitates cranial mobility and specifically addresses the dysfunction of cranial nerve VII, which exits through the
temporal bone, thereby potentially alleviating symptoms associated with Bell's Palsy. This technique enhances the circulation and
function of the facial nerve by promoting lymphatic drainage and reducing cranial tension.
Page 3
, Q7 QUESTION 7 OF 105
Anterior shoulder pain with limited supination
CORRECT ANSWER
biceps tendonitis
RATIONALE
Biceps tendonitis is characterized by inflammation of the biceps tendon at the shoulder, often resulting in anterior shoulder pain and
restricted supination due to pain and weakness in the biceps muscle's function. Understanding the biomechanics of shoulder
movement reveals how tendonitis can impair both motion and strength, particularly during supination.
Q8 QUESTION 8 OF 105
HIV patient with white opaque patches with hemorrhagic necrosis of retina
CORRECT ANSWER
CMV retinitis
RATIONALE
Cytomegalovirus (CMV) retinitis is characterized by retinal necrosis and the presence of white, opaque patches, particularly in
immunocompromised individuals such as those with HIV. This condition results from the reactivation of latent CMV, leading to
significant vision loss if untreated.
Q9 QUESTION 9 OF 105
Teenager is given amoxicillin which causes rash and tests negative for heterophile antibody test
CORRECT ANSWER
CMV
RATIONALE
Amoxicillin can induce a rash in individuals with Epstein-Barr virus (EBV) infection, but a negative heterophile antibody test suggests an
alternative viral etiology. Cytomegalovirus (CMV) remains a plausible cause of mononucleosis-like symptoms without the associated
heterophile antibodies.
Q10 QUESTION 10 OF 105
Page 4
