NUR 751 – NMBDs Questions and Answers | 2026
Update | 100% Correct.
alpha ; Ach ; gamma ; extrajunctional ; skeletal
Nicotinic Ach Receptor (nAchR):
-Composed of 5 peptides = 2 _____ peptides (where 2 ___ molecules bind to) + 1 beta peptide
+ 1 delta peptide + 1 epsilon peptide (replaces _____ peptide after birth -> can reappear
in ___________ receptors after denervation later in life)
-nAchR = _______ muscle receptor
voltage ; Ca2+ ; exocytosis ; alpha ; Na+ ; Na+/K+ ; depolarization ; voltage ; more ;
voltage ; potential
AP Generation:
-Motor junction AP -> opens _______ gated ___-channels -> _________ of Ach -> 2 Ach bind
to nAchR (2 _____ subunits) -> produces conformational change to open ___ channel ->
movement of ___ in/__ out -> causes ____________ of motor end plate (EPP) -> carried out
by ______ gated Na+ channels opening throughout skeletal muscle membrane -> muscle AP
-____ Na+ influxing than K+ effluxing = causes change in ______/polarity = called motor
end plate _________ (EPP, NOT the muscle AP)
magnitude ; excitation-contraction ; acetylcholinesterase
AP:
-_________ of AP = directly r/t amount of Ach released
,-If potential generated = ________-________ (E-C) coupling follows (DHPR/RyR1 -> Ca2+
release from SR)
-Ach quickly removed from end plate area by diffusion + enzymatic
destruction (________________ enzyme)
mobilizes ; vesicles ; NOT ; upregulate ; Sux ; K+ ; hyperK+
Other Ach Receptors:
-Presynaptic motor axon terminal AchR = _______ Ach ______ toward synaptic membrane
-Extrajunctional = ___ involved in neuromuscular transmission + will _______ w/ prolonged
immobility or burns (since decreased stimulation) -> if so -> giving depolarizing agent (___)
-> even MORE __ efflux than usual -> ______ issue
sux ; steroidal ; competitive ; ED95 ; height ; single ; 50%
NMBDs:
-___ = 2 Ach molecules together
-_______ non-depolarizing agents = _________ antagonists = roc/vec/panc
-____ = dose at which 95% decrease in twitch _____ is noted in a _____ twitch stimulation
in ___ of pts
alpha ; depolarization ; contraction ; slow ; sustained ; repolarization ; Ach ; blockade ;
flaccid
Succinylcholine (Anectine): MOA
, -Attaches to one/both _____ subunits of nAchr -> ____________ of postjunctional
membrane -> spreads to adjacent muscles causing ___________
-Compared to Ach, hydrolysis of sux is ___ -> ___________ depolarization (opening) of
receptor ion channel & postjunctional membrane -> does NOT allow for ____________
(return to normal voltage) -> INABILITY to respond to ___ = neuromuscular ______
(______ paralysis)
depolarizing ; decreased ; sustained ; absence ; fasciculation ; slows ; augmentation ; 2
Phase 1 Block:
-_________ neuromuscular blockade = phase 1 blockade
-________ amplitude/contraction (to single twitch) BUT _________/consistent response
to continuous stimulation (NO fade)
-_________ of post-tetanic facilitation/potentiation
-TOF ratio >0.7 + onset accompanied by _____________ (muscle twitches)
-Administration of anticholinesterase drug -> ____ breakdown of Sux -> ____________ of
blockade + but can turn block into a phase _ block
desensitizing ; abrupt ; 2-4 ; anticholinesterase ; tachyphylaxis ; increased
Phase 2 Block:
-__________ block
-Transition b/w phase 1 & 2 blockade = fairly _____
-Occurs w/ high sux doses (_-_ mg/kg IV) + giving _____________ to pt in phase 1 block
Update | 100% Correct.
alpha ; Ach ; gamma ; extrajunctional ; skeletal
Nicotinic Ach Receptor (nAchR):
-Composed of 5 peptides = 2 _____ peptides (where 2 ___ molecules bind to) + 1 beta peptide
+ 1 delta peptide + 1 epsilon peptide (replaces _____ peptide after birth -> can reappear
in ___________ receptors after denervation later in life)
-nAchR = _______ muscle receptor
voltage ; Ca2+ ; exocytosis ; alpha ; Na+ ; Na+/K+ ; depolarization ; voltage ; more ;
voltage ; potential
AP Generation:
-Motor junction AP -> opens _______ gated ___-channels -> _________ of Ach -> 2 Ach bind
to nAchR (2 _____ subunits) -> produces conformational change to open ___ channel ->
movement of ___ in/__ out -> causes ____________ of motor end plate (EPP) -> carried out
by ______ gated Na+ channels opening throughout skeletal muscle membrane -> muscle AP
-____ Na+ influxing than K+ effluxing = causes change in ______/polarity = called motor
end plate _________ (EPP, NOT the muscle AP)
magnitude ; excitation-contraction ; acetylcholinesterase
AP:
-_________ of AP = directly r/t amount of Ach released
,-If potential generated = ________-________ (E-C) coupling follows (DHPR/RyR1 -> Ca2+
release from SR)
-Ach quickly removed from end plate area by diffusion + enzymatic
destruction (________________ enzyme)
mobilizes ; vesicles ; NOT ; upregulate ; Sux ; K+ ; hyperK+
Other Ach Receptors:
-Presynaptic motor axon terminal AchR = _______ Ach ______ toward synaptic membrane
-Extrajunctional = ___ involved in neuromuscular transmission + will _______ w/ prolonged
immobility or burns (since decreased stimulation) -> if so -> giving depolarizing agent (___)
-> even MORE __ efflux than usual -> ______ issue
sux ; steroidal ; competitive ; ED95 ; height ; single ; 50%
NMBDs:
-___ = 2 Ach molecules together
-_______ non-depolarizing agents = _________ antagonists = roc/vec/panc
-____ = dose at which 95% decrease in twitch _____ is noted in a _____ twitch stimulation
in ___ of pts
alpha ; depolarization ; contraction ; slow ; sustained ; repolarization ; Ach ; blockade ;
flaccid
Succinylcholine (Anectine): MOA
, -Attaches to one/both _____ subunits of nAchr -> ____________ of postjunctional
membrane -> spreads to adjacent muscles causing ___________
-Compared to Ach, hydrolysis of sux is ___ -> ___________ depolarization (opening) of
receptor ion channel & postjunctional membrane -> does NOT allow for ____________
(return to normal voltage) -> INABILITY to respond to ___ = neuromuscular ______
(______ paralysis)
depolarizing ; decreased ; sustained ; absence ; fasciculation ; slows ; augmentation ; 2
Phase 1 Block:
-_________ neuromuscular blockade = phase 1 blockade
-________ amplitude/contraction (to single twitch) BUT _________/consistent response
to continuous stimulation (NO fade)
-_________ of post-tetanic facilitation/potentiation
-TOF ratio >0.7 + onset accompanied by _____________ (muscle twitches)
-Administration of anticholinesterase drug -> ____ breakdown of Sux -> ____________ of
blockade + but can turn block into a phase _ block
desensitizing ; abrupt ; 2-4 ; anticholinesterase ; tachyphylaxis ; increased
Phase 2 Block:
-__________ block
-Transition b/w phase 1 & 2 blockade = fairly _____
-Occurs w/ high sux doses (_-_ mg/kg IV) + giving _____________ to pt in phase 1 block
