Maryville Pharm Exam 3 Questions With
Correct Answers
Colchicine use - CORRECT ANSWER✔✔-Reduce incidence of acute
|| || || || || || || ||
gout attacks
||
|| relieves pain and discomfort (although it is not an analgesic)
|| || || || || || || || ||
Colchicine Actions - CORRECT ANSWER✔✔-inhibits migration of
|| || || || || || ||
granulocytes to the inflamed areas
|| || || ||
Reduces lactic acid production by granulocytes
|| || || || ||
decreases deposition of uric acid
|| || || || ||
interferes with kinin formation and reduces phagocytosis
|| || || || || ||
Overall effect is it decreases the inflammatory response to urate
|| || || || || || || || || ||
crystals
,Colchicine cautions - CORRECT ANSWER✔✔-Renal Failure- not
|| || || || || || ||
effective in the presence of renal failure. Poorly excreted with RF.
|| || || || || || || || || ||
Hepatic dysfunction- associated with hepatotoxicity
|| || || ||
Peptic ulcer disease or spastic colon- will worsen GI disturbances
|| || || || || || || || ||
Colchicine Adverse Effects - CORRECT ANSWER✔✔-Nausea, vomiting,
|| || || || || ||
diarrhea, and abdominal pain
|| || || ||
Malabsorption of vitamin B12 || || ||
Elevated levels with RF may lead to myopathy, neuropathy, & muscle
|| || || || || || || || || ||
weakness
||
Colchicine low dose therapy - CORRECT ANSWER✔✔-1.2 mg initial
|| || || || || || || || ||
dose followed by 0.6 mg one hour later or 1.8 mg total. High dose
|| || || || || || || || || || || || || ||
is a 4.8 mg total dose. High dose is no longer recommended
|| || || || || || || || || || || ||
because low dose is just as effective with less side effects.
|| || || || || || || || || ||
Febuxostat Patient teaching - CORRECT ANSWER✔✔-Risk of Gout
|| || || || || || || ||
flare up when just starting
|| || || ||
,Contraindicated in patients taking xanthine oxidase because of
|| || || || || || || ||
increased risk of toxicity.
|| || ||
Corticosteroid Adverse effects when taken > 6 months - CORRECT
|| || || || || || || || || ||
ANSWER✔✔-Adrenal Suppression ||
Osteoporosis- increased osteoclastic activity
|| || ||
Worsen Diabetic control
|| ||
May mask infections
|| ||
Report Tarry black stools or abdominal pain
|| || || || || ||
Colchicine Monitoring - CORRECT ANSWER✔✔-BUN, Creatinine,
|| || || || || ||
Creatinine clearance, serum uric acid levels (goal is < 6).
|| || || || || || || || ||
Corticosteroid adverse effects - CORRECT ANSWER✔✔-Mask
|| || || || || ||
infections
Exacerbation of fungal infections ( don't use)
|| || || || || ||
HTN due to NA & H20 retention
|| || || || || ||
Edema with renal disease
|| || ||
, Osteoporosis
Altered glucose regulation in diabetics
|| || || ||
Increased GI bleeding & perforation esp. with PUD and UC pts.
|| || || || || || || || || ||
Altered growth & development in children
|| || || || ||
Skin thinning & atrophy
|| || ||
Alopecia
Poor wound healing
|| ||
Myopathy ||
Truncal obesity, moon face & buffalo hump
|| || || || || ||
Corticosteroid monitoring - CORRECT ANSWER✔✔-BP, glucose,
|| || || || || ||
electrolytes, Bone Mineral Density, monitor for cataracts & glaucoma
|| || || || || || || ||
Steroid psychosis - CORRECT ANSWER✔✔-Delirium, agitation,
|| || || || || ||
insomnia, mood swings, severe depression
|| || || ||
Reasons for steroid tapering - CORRECT ANSWER✔✔-Avoid
|| || || || || || ||
recurrence of underlying disease process
|| || || ||
Gradually reverse adrenal suppression
|| || ||
Correct Answers
Colchicine use - CORRECT ANSWER✔✔-Reduce incidence of acute
|| || || || || || || ||
gout attacks
||
|| relieves pain and discomfort (although it is not an analgesic)
|| || || || || || || || ||
Colchicine Actions - CORRECT ANSWER✔✔-inhibits migration of
|| || || || || || ||
granulocytes to the inflamed areas
|| || || ||
Reduces lactic acid production by granulocytes
|| || || || ||
decreases deposition of uric acid
|| || || || ||
interferes with kinin formation and reduces phagocytosis
|| || || || || ||
Overall effect is it decreases the inflammatory response to urate
|| || || || || || || || || ||
crystals
,Colchicine cautions - CORRECT ANSWER✔✔-Renal Failure- not
|| || || || || || ||
effective in the presence of renal failure. Poorly excreted with RF.
|| || || || || || || || || ||
Hepatic dysfunction- associated with hepatotoxicity
|| || || ||
Peptic ulcer disease or spastic colon- will worsen GI disturbances
|| || || || || || || || ||
Colchicine Adverse Effects - CORRECT ANSWER✔✔-Nausea, vomiting,
|| || || || || ||
diarrhea, and abdominal pain
|| || || ||
Malabsorption of vitamin B12 || || ||
Elevated levels with RF may lead to myopathy, neuropathy, & muscle
|| || || || || || || || || ||
weakness
||
Colchicine low dose therapy - CORRECT ANSWER✔✔-1.2 mg initial
|| || || || || || || || ||
dose followed by 0.6 mg one hour later or 1.8 mg total. High dose
|| || || || || || || || || || || || || ||
is a 4.8 mg total dose. High dose is no longer recommended
|| || || || || || || || || || || ||
because low dose is just as effective with less side effects.
|| || || || || || || || || ||
Febuxostat Patient teaching - CORRECT ANSWER✔✔-Risk of Gout
|| || || || || || || ||
flare up when just starting
|| || || ||
,Contraindicated in patients taking xanthine oxidase because of
|| || || || || || || ||
increased risk of toxicity.
|| || ||
Corticosteroid Adverse effects when taken > 6 months - CORRECT
|| || || || || || || || || ||
ANSWER✔✔-Adrenal Suppression ||
Osteoporosis- increased osteoclastic activity
|| || ||
Worsen Diabetic control
|| ||
May mask infections
|| ||
Report Tarry black stools or abdominal pain
|| || || || || ||
Colchicine Monitoring - CORRECT ANSWER✔✔-BUN, Creatinine,
|| || || || || ||
Creatinine clearance, serum uric acid levels (goal is < 6).
|| || || || || || || || ||
Corticosteroid adverse effects - CORRECT ANSWER✔✔-Mask
|| || || || || ||
infections
Exacerbation of fungal infections ( don't use)
|| || || || || ||
HTN due to NA & H20 retention
|| || || || || ||
Edema with renal disease
|| || ||
, Osteoporosis
Altered glucose regulation in diabetics
|| || || ||
Increased GI bleeding & perforation esp. with PUD and UC pts.
|| || || || || || || || || ||
Altered growth & development in children
|| || || || ||
Skin thinning & atrophy
|| || ||
Alopecia
Poor wound healing
|| ||
Myopathy ||
Truncal obesity, moon face & buffalo hump
|| || || || || ||
Corticosteroid monitoring - CORRECT ANSWER✔✔-BP, glucose,
|| || || || || ||
electrolytes, Bone Mineral Density, monitor for cataracts & glaucoma
|| || || || || || || ||
Steroid psychosis - CORRECT ANSWER✔✔-Delirium, agitation,
|| || || || || ||
insomnia, mood swings, severe depression
|| || || ||
Reasons for steroid tapering - CORRECT ANSWER✔✔-Avoid
|| || || || || || ||
recurrence of underlying disease process
|| || || ||
Gradually reverse adrenal suppression
|| || ||
