NBME CBSE ACTUAL EXAM 2026/2027 WITH
VERIFIED QUESTIONS AND DETAILED
ANSWERS| A+ GRADED|GUARANTEED PASS
70yo M dies in a motor vehicle collision. Was undergoing evaluation for occult blood in the
stool. Photo of transverse colon shown. Dx?
Tubular adenoma or villous polyp. GI blood loss suggests a risk for malignancy
38yo M truck driver with 1-week hx of watery, itchy eyes and a runny nose. Physical shows
inflamed nasal mucosa. No congestion in lower lung. Pharmacotherapy?
Loratadine--> less sedating antihistamine
16yo girl with 3-day hx of fever, nonproductive cough, and fatigue. T 38.3, P 88/min, BP 102-
70. PE shows pale conjunctivae. CXR shows bilateral interstitial infiltrates. Blood
spontaenously agglutinates while awaiting transport to the laboratory. Antibody isotypes
causing agglutination?
IgM (mono and mycoplasma)
24yo M with small tender blisters on his penis 3 days after unprotected sex. Photograph
shown. Causal agent?
HSV-2
42yo F with 3-year hx of an intermittent facial rash, including the forehead, eyelids, nose,
and cheeks. Rash seems to be getting worse since she moved from New York to Florida last
year. Spicy foods precipitate a flushing reaction that seems to exacerbate the rash. PE
shows erythema over the nose and cheeks, with scattered telangiectasias and a few
papules. Dx?
Rosacea
53yo M returned from Africa, has fever, headache, and abdominal discomfort. Received
appropriate vaccinations prior to the trip. T 39.4C. A wright-stained peripheral smear
shown (ring forms in RBCs). Dx?
Malaria
,68yo F with T2DM and hypertension that has been poorly controlled despite
hydrochlorothiazide treatment. BP 150/96, Labs show serum glucose concentration of 130
and proteinuria. In addition to current Rx, which is most appropriate pharmacotherapy?
ACE I (Lisinopril)
66yo M with stage IV colon cancer with 3-day hx of severe diarrhea after receiving
chemotherapy with flourouracil, leucovorin, and irinotecan. Prescribed opioid antidiarrheal
agent with no CNS effects. Which med?
Loperamide
35yo M in ED with 2-hour hx of sever fatigue and dizziness. Had profuse, watery diarrhea for
8 hours despite a lack of oral intake. Recently returned from a medical relief trip to a
remove village in Honduras. T 36.7 C, P 122/min, BP 90/50. PE shows dry skin and
decreased capillary refill. Stool for occult blood is negative; stool is gray and turbid. Gram
stain shows gram-negative, comma-shaped bacteria; no erythrocytes of leukocytes. MOA
of toxin?
V. Cholerae--> activates AC
59yo F with gradual onset of lack of muscle control in her left arm and leg. Sx 1 mo ago
after dx with metastatic breast cancer. PE shows ataxia of left upper and lower extremities.
Muscle strength, DTR, sensation, proprioception normal. Metastatic tumor in which
location?
Cerebellum
Newborn delivered at 38 weeks' gestation weighs 1800 g. PE shows petechial rash,
microcephaly, and hepatosplenomegaly. Serologic test for CMV: IgG + in mother, + in
newborn; IGM - in mother, + in newborn. Explanation?
Congenital CMV infection
Female newborn is delivered at 38 weeks' gestation. Apgar 8 and 8 at 1/5 min. PE shows a
bulging, fluod0filled mass approximately 5 cm in diameter in the midline over the
lumbosacral region. No spontaneous movements of the lower extremities. Abnormality
most likely occurred because of abnormal development during which periods of
postconception (in days)?
15-40; neutral tube closes at about 4 weeks
64yo M in ED 3 hours after SOB with exertion and extreme fatigue. Has ischemic heart
disease. P 125/min, BP 105/60. ECG shows atrial fibrillation. Intravenous ibutilide is
, administered. Ten minutes later, ECG shows normal sinus rhythm. Risk for which drug
effect in the next 6 hours?
Torsades de pointes
65yo F with 20-year hx of osteoarthritis of the hands now has pain radiating down the distal
anterior thigh, knee, medial leg, and food. Bony outgrowth of vertebrae compressing one of
the spinal nerves is suspected. Nerve root in which intervertebral foramina is effected?
L3 to L4
38yo M with 3-year hx of T2DM. Taking an oral antihyperglycemic agent, he has tried diet
and exercise. BMI 32. PE normal. Hb A1c is 10%. Physician recommends initiation of
insulin injections. Responds, "I know that insulin would help control my blood sugar. But a
lot of people in my family have diabetes, and insulin made them really sick at times. Patient
is at which stage of change?
Contemplation
24yo M with 2-day history of an itchy rash on his arms and legs. Returned from a camping
trip in the woods 5 days ago. PE shows edematous, erythematous rash with linear vesicles.
Cause is activation of which cell types?
T-lymphocytes (type IV HS)
70yo M from china with poorly differentiated monoclonal carcinoma of the nasopharynx.
DNA probes of neoplastic cells are most likely to detect genome of which virus?
EBV
24yo M with hx of IVDA could not be aroused. Friend reports that the patient injected
himself with a drug 6 hours ago. Labs show drug concentration of 0.3. Assuming first-order
one-compartment kinetics, has a half-life of 2 hours, and a volume of distribution of 200 L
in this patient. What is quantity of drug (in mg) injected?
= 200 (0.3) =60
3 half-lives = 120, 240, 480
Compound is taken up by bacterial cells. No energy is necessary for uptake, and the
compound is not concentrated in the cell. Which describes this mechanism of transport?
Carrier-mediated diffusion
VERIFIED QUESTIONS AND DETAILED
ANSWERS| A+ GRADED|GUARANTEED PASS
70yo M dies in a motor vehicle collision. Was undergoing evaluation for occult blood in the
stool. Photo of transverse colon shown. Dx?
Tubular adenoma or villous polyp. GI blood loss suggests a risk for malignancy
38yo M truck driver with 1-week hx of watery, itchy eyes and a runny nose. Physical shows
inflamed nasal mucosa. No congestion in lower lung. Pharmacotherapy?
Loratadine--> less sedating antihistamine
16yo girl with 3-day hx of fever, nonproductive cough, and fatigue. T 38.3, P 88/min, BP 102-
70. PE shows pale conjunctivae. CXR shows bilateral interstitial infiltrates. Blood
spontaenously agglutinates while awaiting transport to the laboratory. Antibody isotypes
causing agglutination?
IgM (mono and mycoplasma)
24yo M with small tender blisters on his penis 3 days after unprotected sex. Photograph
shown. Causal agent?
HSV-2
42yo F with 3-year hx of an intermittent facial rash, including the forehead, eyelids, nose,
and cheeks. Rash seems to be getting worse since she moved from New York to Florida last
year. Spicy foods precipitate a flushing reaction that seems to exacerbate the rash. PE
shows erythema over the nose and cheeks, with scattered telangiectasias and a few
papules. Dx?
Rosacea
53yo M returned from Africa, has fever, headache, and abdominal discomfort. Received
appropriate vaccinations prior to the trip. T 39.4C. A wright-stained peripheral smear
shown (ring forms in RBCs). Dx?
Malaria
,68yo F with T2DM and hypertension that has been poorly controlled despite
hydrochlorothiazide treatment. BP 150/96, Labs show serum glucose concentration of 130
and proteinuria. In addition to current Rx, which is most appropriate pharmacotherapy?
ACE I (Lisinopril)
66yo M with stage IV colon cancer with 3-day hx of severe diarrhea after receiving
chemotherapy with flourouracil, leucovorin, and irinotecan. Prescribed opioid antidiarrheal
agent with no CNS effects. Which med?
Loperamide
35yo M in ED with 2-hour hx of sever fatigue and dizziness. Had profuse, watery diarrhea for
8 hours despite a lack of oral intake. Recently returned from a medical relief trip to a
remove village in Honduras. T 36.7 C, P 122/min, BP 90/50. PE shows dry skin and
decreased capillary refill. Stool for occult blood is negative; stool is gray and turbid. Gram
stain shows gram-negative, comma-shaped bacteria; no erythrocytes of leukocytes. MOA
of toxin?
V. Cholerae--> activates AC
59yo F with gradual onset of lack of muscle control in her left arm and leg. Sx 1 mo ago
after dx with metastatic breast cancer. PE shows ataxia of left upper and lower extremities.
Muscle strength, DTR, sensation, proprioception normal. Metastatic tumor in which
location?
Cerebellum
Newborn delivered at 38 weeks' gestation weighs 1800 g. PE shows petechial rash,
microcephaly, and hepatosplenomegaly. Serologic test for CMV: IgG + in mother, + in
newborn; IGM - in mother, + in newborn. Explanation?
Congenital CMV infection
Female newborn is delivered at 38 weeks' gestation. Apgar 8 and 8 at 1/5 min. PE shows a
bulging, fluod0filled mass approximately 5 cm in diameter in the midline over the
lumbosacral region. No spontaneous movements of the lower extremities. Abnormality
most likely occurred because of abnormal development during which periods of
postconception (in days)?
15-40; neutral tube closes at about 4 weeks
64yo M in ED 3 hours after SOB with exertion and extreme fatigue. Has ischemic heart
disease. P 125/min, BP 105/60. ECG shows atrial fibrillation. Intravenous ibutilide is
, administered. Ten minutes later, ECG shows normal sinus rhythm. Risk for which drug
effect in the next 6 hours?
Torsades de pointes
65yo F with 20-year hx of osteoarthritis of the hands now has pain radiating down the distal
anterior thigh, knee, medial leg, and food. Bony outgrowth of vertebrae compressing one of
the spinal nerves is suspected. Nerve root in which intervertebral foramina is effected?
L3 to L4
38yo M with 3-year hx of T2DM. Taking an oral antihyperglycemic agent, he has tried diet
and exercise. BMI 32. PE normal. Hb A1c is 10%. Physician recommends initiation of
insulin injections. Responds, "I know that insulin would help control my blood sugar. But a
lot of people in my family have diabetes, and insulin made them really sick at times. Patient
is at which stage of change?
Contemplation
24yo M with 2-day history of an itchy rash on his arms and legs. Returned from a camping
trip in the woods 5 days ago. PE shows edematous, erythematous rash with linear vesicles.
Cause is activation of which cell types?
T-lymphocytes (type IV HS)
70yo M from china with poorly differentiated monoclonal carcinoma of the nasopharynx.
DNA probes of neoplastic cells are most likely to detect genome of which virus?
EBV
24yo M with hx of IVDA could not be aroused. Friend reports that the patient injected
himself with a drug 6 hours ago. Labs show drug concentration of 0.3. Assuming first-order
one-compartment kinetics, has a half-life of 2 hours, and a volume of distribution of 200 L
in this patient. What is quantity of drug (in mg) injected?
= 200 (0.3) =60
3 half-lives = 120, 240, 480
Compound is taken up by bacterial cells. No energy is necessary for uptake, and the
compound is not concentrated in the cell. Which describes this mechanism of transport?
Carrier-mediated diffusion
