TEST BANK
Tietz Fundamentals Of
CLINICAL CHEMISTRY AND
MOLECULAR DIAGNOSTICS
7th Edition By Carl A. Burtis
TEST BANK
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 7th Edition Test Bank
Table of contents:
I. Principles Of Laboratory Medicine
Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
Chapter 3. Clinical Evaluation of Methods
Chapter 4. Evidence-Based Laboratory Medicine
Chapter 5. Establishment and Use of Reference Values
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
Chapter 7. Quality Management
II. Analytical Techniques And Instrumentation
Chapter 8. Principles of Basic Techniques and Laboratory Safety
Chapter 9. Optical Techniques
Chapter 10. Electrochemistry and Chemical Sensors
Chapter 11. Electrophoresis
Chapter 12. Chromatography
Chapter 13. Mass Spectrometry
Chapter 14. Enzyme and Rate Analyses
Chapter 15. Immunochemical Techniques
Chapter 16 Automation
Chapter 17. Point-of-Care Instrumentation
III. Analytes
Chapter 18. Amino Acids, Peptides, and Proteins
Chapter 19. Serum Enzymes
Chapter 20. Tumor Markers and Cancer Genes
Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
Chapter 22. Carbohydrates
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
Chapter 24. Electrolytes and Blood Gases
Chapter 25. Hormones
Chapter 26. Catecholamines and Serotonin
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
Chapter 28. Hemoglobin, Iron, and Bilirubin
Chapter 29. Porphyrins and Porphyrias
Chapter 30. Therapeutic Drugs and Their Management
Chapter 31. Clinical Toxicology
Chapter 32. Toxic Metals
IV. Pathophysiology
Chapter 33. Diabetes
,Chapter 34. Cardiovascular Disease
Chapter 35. Kidney Disease
Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
Chapter 37. Liver Disease
Chapter 38. Gastrointestinal and Pancreatic Diseases
Chapter 39. Disorders of Bone and Mineral Metabolism
Chapter 40. Disorders of the Pituitary Gland
Chapter 41. Disorders of the Adrenal Cortex
Chapter 42. Thyroid Disorders
Chapter 43. Reproduction-Related Disorders
Chapter 44. Pregnancy and Prenatal Testing
Chapter 45. Newborn Screening and Inborn Errors of Metabolism
Chapter 46. Pharmacogenetics
V. Molecular Diagnostics
Chapter 47. Principles of Molecular Biology
Chapter 48. Nucleic Acid Techniques and Applications
Chapter 49. Genomes and Nucleic Acid Alterations
,Tietz Fundamentals of Clinical Chemistry and MolecularDiagnostics, 7e Burtis Test Bank
Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory MedicineTest
Bank
MULTIPLE CHOICE
1. An individual working in a clinical chemistry laboratory is married to a sales representative
who works for a company that sells chemistry laboratory supplies. When the laboratory
manager requests a list of needed supplies, cost of supplies, and vendors, this individual only
recommends the spouse’s company as the vendor. This is considered to be a(n):
a. accounting issue.
b. possible conflict of interest.
c. maintenance of confidentiality issue.
d. problem with resource allocation.
ANS: B
Concern has been raised over the interrelationships between practitioners in the medical field
and commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
Similarly, relationships have been scrutinized between clinical laboratorians and
manufacturers and providers of diagnostic equipment and supplies. These concerns led the
National Institutes of Health (NIH) in 1995 to require official institutional review of financial
disclosure by researchers and management of situations in which disclosure indicates potential
conflicts of interest.
DIF: 1 REF: Page 4-5 OBJ: 6 | 7
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce
the pain following her recent surgery. A friend of the patient claims that the same painkiller
“worked wonders” to reduce her pain after the same surgery. The physician states that the
difference in the effect of the drug might be caused by , which is studied in
pharmacogenetics.
a. epidemiology
b. an inherited disease
c. a conflict of interest
d. a genetic variation in drug-metabolizing enzymes
ANS: D
Pharmacogenetics is the study of the genetic variation of drug metabolism between
individuals.
DIF: 1 REF: Page 3 OBJ: 1
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the
name of a close friend printed on the bar-coded label. The genetic test that is ordered on the
friend’s sample would provide diagnostic information about a disorder that has a poor
prognosis, and the test is usually performed by John. He asks a fellow employee to analyze
the sample for him and not divulge the results. This ethical issue concerns:
a. confidentiality of patient genetic and medical information.
b. a conflict of interest.
c. resource allocation.
d. diagnostic accuracy.
, ANS:t 1 A
Clinicalt1laboratorianst1havet1longt1beent1responsiblet1fort1maintainingt1thet1co
nfidentialityt1oft1alllaboratoryt1results,t1at1situationt1madet1event1moret1critica
lt1witht1thet1adventt1oft1increasinglyt1powerfult1genetict1testing.
DIF: 1 REF:t 1 t 1 Paget14 OBJ:t 1 6t1|t17
4. Moleculart1diagnostict1testingt1methodst1andt1resultst1cant1be:
a. qualitativet1only.
b. quantitativet1only.
c. eithert1qualitativet1ort1quantitative.
ANS:t 1 C
Moleculart1diagnostict1methodst1cant1bet1eithert1qualitativet1ort1quantitativet1int
1nature,t1dependingt1onthet1clinicalt1need.
DIF: 1 REF:t 1 t 1 Paget13 OBJ:t 1 5
5. Clinicalt1epidemiology,t1whicht1ist1thet1studyt1oft1thet1patterns,t1causes,t1andt1e
ffectst1oft1healtht1andt1diseaset1int1certaint1populations,t1hast1providedt1thet1cli
nicalt1laboratoryt1witht1methodst1thatt1evaluatethet1effectst1andt1outcomest1oft1l
aboratoryt1testing.t1Thist1allowst1fort1at1moret1effective:
a. processt1oft1determiningt1thet1costt1oft1thet1testingt1methods.
b. selectiont1andt1interpretationt1oft1laboratoryt1tests.
c. determinationt1oft1thet1boundariest1betweent1thet1componentst1oft1thet1clinicalt1lab.
d. conductt1assessment.
ANS:t 1 A
Clinicalt1epidemiologistst1havet1introducedt1methodst1tot1evaluatet1thet1effects
t1andt1valuet1oft1laboratoryt1testingt1int1healthcare.t1Theset1developmentst1aret1
expectedt1tot1playt1ant1increasingt1rolet1inthet1selectiont1andt1interpretationt1oft
1laboratoryt1tests.
DIF: 1 REF:t 1 t 1 Paget13 OBJ:t 1 4
6. Analysist1oft1whicht1onet1oft1thet1followingt1byt1moleculart1diagnostict1method
st1providest1at1measureoft1processest1thatt1aret1ongoingt1att1thet1timet1oft1blood
t1sampling?
a. Genetict1variationt1int1ant1individual’st1responset1tot1at1drug
b. Circulatingt1plasmat1nucleict1acids
c. Malignantt1lymphomas
d. Histocompatibility
ANS:t 1 B
Moleculart1diagnostics,t1givent1itst1veryt1hight1sensitivity,t1hast1beent1appliedt1tot1
thet1studyt1oft1plasmanucleict1acidst1(ort1circulatingt1nucleict1acids).t1Plasmat1nu
cleict1acidst1analysist1hast1beent1madet1possiblet1byt1thet1discoveryt1thatt1dyingt1cel
lst1int1thet1bodyt1releaset1theirt1DNAt1andt1RNAt1intot1thet1extracellular
, Tot1downloadt1completet1file,t1pleaset1clickt1ont1belowt1linkt1ort1copyt1itt1intot1yourt1inte
rnett1Browser
OR
Presst1Ctrlt1+t1Entert1tot1opent1thet1link
https://drive.google.com/file/d/1CBYHZEkda7RPIIiePoFOgVJKwDQNJz4x/vt1iew?u
sp=sharing
Tot1downloadt1completet1file,t1pleaset1clickt1ont1belowt1linkt1ort1copyt1itt1intot1yourt1inte
rnett1Browser
OR
Presst1Ctrlt1+t1Entert1tot1opent1thet1link
https://drive.google.com/file/d/1CBYHZEkda7RPIIiePoFOgVJKwDQNJz4x/vt1iew?u
sp=sharing
, Tot1downloadt1completet1file,t1pleaset1clickt1ont1belowt1linkt1ort1copyt1itt1intot1yourt1inte
rnett1Browser
OR
Presst1Ctrlt1+t1Entert1tot1opent1thet1link
https://drive.google.com/file/d/1CBYHZEkda7RPIIiePoFOgVJKwDQNJz4x/vt1iew?u
sp=sharing
, Tot1downloadt1completet1file,t1pleaset1clickt1ont1belowt1linkt1ort1copyt1itt1intot1yourt1inte
rnett1Browser
OR
Presst1Ctrlt1+t1Entert1tot1opent1thet1link
https://drive.google.com/file/d/1CBYHZEkda7RPIIiePoFOgVJKwDQNJz4x/vt1iew?u
sp=sharing
Tot1downloadt1completet1file,t1pleaset1clickt1ont1belowt1linkt1ort1copyt1itt1intot1yourt1inte
rnett1Browser
OR
Presst1Ctrlt1+t1Entert1tot1opent1thet1link
https://drive.google.com/file/d/1CBYHZEkda7RPIIiePoFOgVJKwDQNJz4x/vt1iew?u
sp=sharing
,
,
Tietz Fundamentals Of
CLINICAL CHEMISTRY AND
MOLECULAR DIAGNOSTICS
7th Edition By Carl A. Burtis
TEST BANK
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 7th Edition Test Bank
Table of contents:
I. Principles Of Laboratory Medicine
Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
Chapter 3. Clinical Evaluation of Methods
Chapter 4. Evidence-Based Laboratory Medicine
Chapter 5. Establishment and Use of Reference Values
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
Chapter 7. Quality Management
II. Analytical Techniques And Instrumentation
Chapter 8. Principles of Basic Techniques and Laboratory Safety
Chapter 9. Optical Techniques
Chapter 10. Electrochemistry and Chemical Sensors
Chapter 11. Electrophoresis
Chapter 12. Chromatography
Chapter 13. Mass Spectrometry
Chapter 14. Enzyme and Rate Analyses
Chapter 15. Immunochemical Techniques
Chapter 16 Automation
Chapter 17. Point-of-Care Instrumentation
III. Analytes
Chapter 18. Amino Acids, Peptides, and Proteins
Chapter 19. Serum Enzymes
Chapter 20. Tumor Markers and Cancer Genes
Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
Chapter 22. Carbohydrates
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
Chapter 24. Electrolytes and Blood Gases
Chapter 25. Hormones
Chapter 26. Catecholamines and Serotonin
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
Chapter 28. Hemoglobin, Iron, and Bilirubin
Chapter 29. Porphyrins and Porphyrias
Chapter 30. Therapeutic Drugs and Their Management
Chapter 31. Clinical Toxicology
Chapter 32. Toxic Metals
IV. Pathophysiology
Chapter 33. Diabetes
,Chapter 34. Cardiovascular Disease
Chapter 35. Kidney Disease
Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
Chapter 37. Liver Disease
Chapter 38. Gastrointestinal and Pancreatic Diseases
Chapter 39. Disorders of Bone and Mineral Metabolism
Chapter 40. Disorders of the Pituitary Gland
Chapter 41. Disorders of the Adrenal Cortex
Chapter 42. Thyroid Disorders
Chapter 43. Reproduction-Related Disorders
Chapter 44. Pregnancy and Prenatal Testing
Chapter 45. Newborn Screening and Inborn Errors of Metabolism
Chapter 46. Pharmacogenetics
V. Molecular Diagnostics
Chapter 47. Principles of Molecular Biology
Chapter 48. Nucleic Acid Techniques and Applications
Chapter 49. Genomes and Nucleic Acid Alterations
,Tietz Fundamentals of Clinical Chemistry and MolecularDiagnostics, 7e Burtis Test Bank
Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory MedicineTest
Bank
MULTIPLE CHOICE
1. An individual working in a clinical chemistry laboratory is married to a sales representative
who works for a company that sells chemistry laboratory supplies. When the laboratory
manager requests a list of needed supplies, cost of supplies, and vendors, this individual only
recommends the spouse’s company as the vendor. This is considered to be a(n):
a. accounting issue.
b. possible conflict of interest.
c. maintenance of confidentiality issue.
d. problem with resource allocation.
ANS: B
Concern has been raised over the interrelationships between practitioners in the medical field
and commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
Similarly, relationships have been scrutinized between clinical laboratorians and
manufacturers and providers of diagnostic equipment and supplies. These concerns led the
National Institutes of Health (NIH) in 1995 to require official institutional review of financial
disclosure by researchers and management of situations in which disclosure indicates potential
conflicts of interest.
DIF: 1 REF: Page 4-5 OBJ: 6 | 7
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce
the pain following her recent surgery. A friend of the patient claims that the same painkiller
“worked wonders” to reduce her pain after the same surgery. The physician states that the
difference in the effect of the drug might be caused by , which is studied in
pharmacogenetics.
a. epidemiology
b. an inherited disease
c. a conflict of interest
d. a genetic variation in drug-metabolizing enzymes
ANS: D
Pharmacogenetics is the study of the genetic variation of drug metabolism between
individuals.
DIF: 1 REF: Page 3 OBJ: 1
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the
name of a close friend printed on the bar-coded label. The genetic test that is ordered on the
friend’s sample would provide diagnostic information about a disorder that has a poor
prognosis, and the test is usually performed by John. He asks a fellow employee to analyze
the sample for him and not divulge the results. This ethical issue concerns:
a. confidentiality of patient genetic and medical information.
b. a conflict of interest.
c. resource allocation.
d. diagnostic accuracy.
, ANS:t 1 A
Clinicalt1laboratorianst1havet1longt1beent1responsiblet1fort1maintainingt1thet1co
nfidentialityt1oft1alllaboratoryt1results,t1at1situationt1madet1event1moret1critica
lt1witht1thet1adventt1oft1increasinglyt1powerfult1genetict1testing.
DIF: 1 REF:t 1 t 1 Paget14 OBJ:t 1 6t1|t17
4. Moleculart1diagnostict1testingt1methodst1andt1resultst1cant1be:
a. qualitativet1only.
b. quantitativet1only.
c. eithert1qualitativet1ort1quantitative.
ANS:t 1 C
Moleculart1diagnostict1methodst1cant1bet1eithert1qualitativet1ort1quantitativet1int
1nature,t1dependingt1onthet1clinicalt1need.
DIF: 1 REF:t 1 t 1 Paget13 OBJ:t 1 5
5. Clinicalt1epidemiology,t1whicht1ist1thet1studyt1oft1thet1patterns,t1causes,t1andt1e
ffectst1oft1healtht1andt1diseaset1int1certaint1populations,t1hast1providedt1thet1cli
nicalt1laboratoryt1witht1methodst1thatt1evaluatethet1effectst1andt1outcomest1oft1l
aboratoryt1testing.t1Thist1allowst1fort1at1moret1effective:
a. processt1oft1determiningt1thet1costt1oft1thet1testingt1methods.
b. selectiont1andt1interpretationt1oft1laboratoryt1tests.
c. determinationt1oft1thet1boundariest1betweent1thet1componentst1oft1thet1clinicalt1lab.
d. conductt1assessment.
ANS:t 1 A
Clinicalt1epidemiologistst1havet1introducedt1methodst1tot1evaluatet1thet1effects
t1andt1valuet1oft1laboratoryt1testingt1int1healthcare.t1Theset1developmentst1aret1
expectedt1tot1playt1ant1increasingt1rolet1inthet1selectiont1andt1interpretationt1oft
1laboratoryt1tests.
DIF: 1 REF:t 1 t 1 Paget13 OBJ:t 1 4
6. Analysist1oft1whicht1onet1oft1thet1followingt1byt1moleculart1diagnostict1method
st1providest1at1measureoft1processest1thatt1aret1ongoingt1att1thet1timet1oft1blood
t1sampling?
a. Genetict1variationt1int1ant1individual’st1responset1tot1at1drug
b. Circulatingt1plasmat1nucleict1acids
c. Malignantt1lymphomas
d. Histocompatibility
ANS:t 1 B
Moleculart1diagnostics,t1givent1itst1veryt1hight1sensitivity,t1hast1beent1appliedt1tot1
thet1studyt1oft1plasmanucleict1acidst1(ort1circulatingt1nucleict1acids).t1Plasmat1nu
cleict1acidst1analysist1hast1beent1madet1possiblet1byt1thet1discoveryt1thatt1dyingt1cel
lst1int1thet1bodyt1releaset1theirt1DNAt1andt1RNAt1intot1thet1extracellular
, Tot1downloadt1completet1file,t1pleaset1clickt1ont1belowt1linkt1ort1copyt1itt1intot1yourt1inte
rnett1Browser
OR
Presst1Ctrlt1+t1Entert1tot1opent1thet1link
https://drive.google.com/file/d/1CBYHZEkda7RPIIiePoFOgVJKwDQNJz4x/vt1iew?u
sp=sharing
Tot1downloadt1completet1file,t1pleaset1clickt1ont1belowt1linkt1ort1copyt1itt1intot1yourt1inte
rnett1Browser
OR
Presst1Ctrlt1+t1Entert1tot1opent1thet1link
https://drive.google.com/file/d/1CBYHZEkda7RPIIiePoFOgVJKwDQNJz4x/vt1iew?u
sp=sharing
, Tot1downloadt1completet1file,t1pleaset1clickt1ont1belowt1linkt1ort1copyt1itt1intot1yourt1inte
rnett1Browser
OR
Presst1Ctrlt1+t1Entert1tot1opent1thet1link
https://drive.google.com/file/d/1CBYHZEkda7RPIIiePoFOgVJKwDQNJz4x/vt1iew?u
sp=sharing
, Tot1downloadt1completet1file,t1pleaset1clickt1ont1belowt1linkt1ort1copyt1itt1intot1yourt1inte
rnett1Browser
OR
Presst1Ctrlt1+t1Entert1tot1opent1thet1link
https://drive.google.com/file/d/1CBYHZEkda7RPIIiePoFOgVJKwDQNJz4x/vt1iew?u
sp=sharing
Tot1downloadt1completet1file,t1pleaset1clickt1ont1belowt1linkt1ort1copyt1itt1intot1yourt1inte
rnett1Browser
OR
Presst1Ctrlt1+t1Entert1tot1opent1thet1link
https://drive.google.com/file/d/1CBYHZEkda7RPIIiePoFOgVJKwDQNJz4x/vt1iew?u
sp=sharing
,
,
