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melanoma - Stage I or II
surgery
melanoma - Stage III
nivolumab, ipilumumab
melanoma - BRAF positive Stage III
dabrafenib + trametinib
melanoma - BRAF positive Stage IV, aggressive, bulky, symptomatic
dabrafenib + trametinib, vemurafenib + cobimetinib
melanoma - Unresectable stage III with in-transit lesions
Talimogene Laherparepvec (T-VEC)
melanoma - Stage IV
nivolumab, pembrolizumab
melanoma - BRAF positive Stage IV minimally symptomatic
nivolumab, pembrolizumab, nivolumab + ipilimumab (Stage IV immunotherapy)
,metastatic basal cell carcinoma
vismodegib, sonidegib
CLL - Age < 65 without significant comorbidies without del 17p/TP53
FCR, ibrutinib, bendamustine with or without cd20 MoAb
CLL - Age < 65 without significant comorbidities without del 17p/TP53
relapse/refractory
ibrutinib, idelalisib + R, venetoclax with or without R
CLL - Age < 65 without significant comorbidies without del 17p/TP53
maintenance
consider lenalidomide for high risk
CLL - Age > 65 or younger patients with significant comorbidities without del
17p/TP53
Obinutuzumab + chlorambucil, ibrutinib, ofatumumab + chlorambucil, rituxan +
chlorambucil, bendamustine with or without R
CLL - Age > 65 or younger patients with significant comorbidities without del
17p/TP53 maintenance
consider lenalidomide for high risk
,CLL - Age > 65 or younger patients with significant comorbidities without del
17p/TP53 relapse/refractory
ibrutinib, idelalisib + R, venetoclax with or without R
CLL - Frail patients with significant comorbidities without del 17p/TP53
Obinutuzumab + chlorambucil, ibrutinib, ofatumumab + chlorambucil, rituxan +
chlorambucil
CLL - Frail patients with significant comorbidities without del 17p/TP53
maintenance
consider lenalidomide for high risk
Frail patients with significant comorbidities without del 17p/TP53
relapsed/refractory
ibrutinib, idelalisib + R, venetoclax with or without R
CLL - With del 17p/TP53
ibrutinib**, HDMP + rituxan, obinutuzumab, alemtuzumab with or without
rituxan
CLL - With del 17p/TP53 relapsed/refractory
ibrutinib, idelalisib + R, venetoclax with or without R
CLL - With del 17p/TP53 maintenance
, consider lenalidomide for high risk
NSCLC stage IA
surgery
NSCLC stage IB
surgery
NSCLC stage IIA
surgery followed by cisplatin doublet
NSCLC stage IIB
surgery followed by cisplatin doublet
NSCLC stage IIIA
surgery followed by cisplatin doublet