HEMATOLOGY EXAMS SET QUESTIONS
AND ACCURATE ANSWERS FULL
SOLUTION GUIDE
●● Where does hematopoiesis take place during the first 2 months of
gestation?
Answer: yolk sac
●● Where does the majority of hematopoiesis take place during the 2nd
through 7th month of gestation?
Answer: spleen
●● When does the bone marrow take over hematopoiesis?
Answer: after birth
●● What are the stages in order of the erythrocyte lineage?
Answer: (1)rubriblast, (2)prorubricyte, (3)rubricyte, (4)metarubricyte,
(5)reticulocyte, (6)erytrocyte
●● What are the stages in order of the granulocyte (neutrophil,
eosinophil, basophil) lineage?
Answer: (1)myeloblast, (2)promyelocyte, (3)myelocyte,
(4)metamyelocyte, (5)band, (6)segmented (7)eos/baso
,●● What are the stages in order of the macrophage lineage?
Answer: (1)monoblast, (2)promonocyte, (3)monocyte, (4)macrophage
●● What are the stages in order of the platelet lineage?
Answer: (1)megakaryoblast, (2)promegakaryocyte, (3)megakaryocyte,
(4)platelet
●● What are the stages in order of the lymphocyte lineage?
Answer: (1)lymphoblast, (2)prolymphocyte, (3)lymphocyte
●● Which growth factors stimulate the erythrocyte lineage?
Answer: GM-CSF, EPO, IL-3
●● Which growth factors stimulate the granulocyte lineages?
Answer: GM-CSF, IL-3
●● Which growth factors stimulate the platelet lineage?
Answer: GM-CSF, IL-3, TPO
●● Which growth factors stimulate the lymphocyte lineage?
Answer: IL-2, IL-4, IL-6, IL-7
,●● Which protein functions in the transport of Fe?
Answer: transferrin
●● What is the major storage form of Fe?
Answer: ferritin
●● What is the long-term (H20) insoluble Fe storage form called?
Answer: hemosiderin
●● Excess Iron is stored where? What does this cause?
Answer: tissues and body organs, hemosiderosis, hemochromatosis
●● Porphyrias are attributed to?
Answer: excessive formation of porphrins due to blockages in any
enzymatic step in the heme synthesis pathway.
●● Red or port wine colored urine can be seen in which condition
related to the build up of heme precursors?
Answer: porphyria
●● Neuropsychiatirc symptoms are seen when a build up of which
precursors occurs?
, Answer: early precursors (Delta-aminolevulinic acid/Porphobilinogen)
●● Cutaneous symptoms such as photo-sensitivity and facial hair are
seen when a build up of which precursors occurs?
Answer: later precursors (uroporphyrinogen/coproporphyrinogen,
protoporphyrin/heme)
●● Synthesis of heme requires what two components?
Answer: iron, protoporphyrin
●● What are the heme precursors in order of synthesis?
Answer: (1)delta-aminolevulinic acid, (2)porphobilinogen,
(3)uroporphyrinogen, (4)coproporphyrinogen, (5)protoporphyrin,
(6)heme
●● What type of hemoglobin is seen primarily in newborns?
Answer: Hgb F
●● What type of hemoglobin is seen primarily in adults?
Answer: Hgb A2
●● What type of hemoglobin is rarely seen in adults as well as
newborns?
AND ACCURATE ANSWERS FULL
SOLUTION GUIDE
●● Where does hematopoiesis take place during the first 2 months of
gestation?
Answer: yolk sac
●● Where does the majority of hematopoiesis take place during the 2nd
through 7th month of gestation?
Answer: spleen
●● When does the bone marrow take over hematopoiesis?
Answer: after birth
●● What are the stages in order of the erythrocyte lineage?
Answer: (1)rubriblast, (2)prorubricyte, (3)rubricyte, (4)metarubricyte,
(5)reticulocyte, (6)erytrocyte
●● What are the stages in order of the granulocyte (neutrophil,
eosinophil, basophil) lineage?
Answer: (1)myeloblast, (2)promyelocyte, (3)myelocyte,
(4)metamyelocyte, (5)band, (6)segmented (7)eos/baso
,●● What are the stages in order of the macrophage lineage?
Answer: (1)monoblast, (2)promonocyte, (3)monocyte, (4)macrophage
●● What are the stages in order of the platelet lineage?
Answer: (1)megakaryoblast, (2)promegakaryocyte, (3)megakaryocyte,
(4)platelet
●● What are the stages in order of the lymphocyte lineage?
Answer: (1)lymphoblast, (2)prolymphocyte, (3)lymphocyte
●● Which growth factors stimulate the erythrocyte lineage?
Answer: GM-CSF, EPO, IL-3
●● Which growth factors stimulate the granulocyte lineages?
Answer: GM-CSF, IL-3
●● Which growth factors stimulate the platelet lineage?
Answer: GM-CSF, IL-3, TPO
●● Which growth factors stimulate the lymphocyte lineage?
Answer: IL-2, IL-4, IL-6, IL-7
,●● Which protein functions in the transport of Fe?
Answer: transferrin
●● What is the major storage form of Fe?
Answer: ferritin
●● What is the long-term (H20) insoluble Fe storage form called?
Answer: hemosiderin
●● Excess Iron is stored where? What does this cause?
Answer: tissues and body organs, hemosiderosis, hemochromatosis
●● Porphyrias are attributed to?
Answer: excessive formation of porphrins due to blockages in any
enzymatic step in the heme synthesis pathway.
●● Red or port wine colored urine can be seen in which condition
related to the build up of heme precursors?
Answer: porphyria
●● Neuropsychiatirc symptoms are seen when a build up of which
precursors occurs?
, Answer: early precursors (Delta-aminolevulinic acid/Porphobilinogen)
●● Cutaneous symptoms such as photo-sensitivity and facial hair are
seen when a build up of which precursors occurs?
Answer: later precursors (uroporphyrinogen/coproporphyrinogen,
protoporphyrin/heme)
●● Synthesis of heme requires what two components?
Answer: iron, protoporphyrin
●● What are the heme precursors in order of synthesis?
Answer: (1)delta-aminolevulinic acid, (2)porphobilinogen,
(3)uroporphyrinogen, (4)coproporphyrinogen, (5)protoporphyrin,
(6)heme
●● What type of hemoglobin is seen primarily in newborns?
Answer: Hgb F
●● What type of hemoglobin is seen primarily in adults?
Answer: Hgb A2
●● What type of hemoglobin is rarely seen in adults as well as
newborns?
