NR566 FINAL (ADVANCED PHARMACOLOGY FOR CARE OF THE FAMILY QUESTION WITH VERIFIED ANSWERS

NR566 FINAL (ADVANCED PHARMACOLOGY FOR CARE
OF THE FAMILY QUESTION WITH VERIFIED ANSWERS



Anti-Androgens - ansFinasteride (Propecia) cx cx cx




Leuprolide (Eligard, Lupron, Lupron Depot) cx cx cx cx




Spironolactone (Aldactone) cx




Finasteride (Propecia, Proscar) - cx cx cx




ansblocks conversion of testosterone to dihydrotesterone
cx cx cx cx cx cx




Used to tx: cx cx cx




-BPH cx




-male pattern baldness cx cx cx




3 months of therapy need to see benefits
cx cx cx cx cx cx cx cx




Stopping, reverses effect w/in 12 months cx cx cx cx cx




Adverse side effects: cx cx




- Decreased libido
cx cx cx




-Impotence

dutasteride (Avodart) - ans5-alpha reductase inhibitor cx cx cx cx cx




used to tx: cx cx




BPH cx




Can stay in serum up to 6 mon after discontinuing
cx cx cx cx cx cx cx cx cx




can be absorbed through skin
cx cx cx cx




pregnant woman shouldn't handle capsules cx cx cx cx




(fetal anomaly in male fetus)
cx cx cx cx




Adverse Effects cx




decreased libido cx cx




Impotence

Leuprolide Acetate (Lupron) - ansLuteinizing hormone - releasing agonist
cx cx cx cx cx cx cx cx cx




create reversible: cx




-orchiectomy state cx




-oophorectomy state
cx
cx




Used to tx: cx cx




- advanced prostatic cancer
cx cx cx




- Management of endometriosis
cx cx cx cx




- Uterine fibroids
cx cx

, - polycystic ovarian disease
cx cx cx




- central precocious puberty in peds
cx cx cx cx cx




Flutamide (Eulexin, Euflex) - ansTruly non-steroidal agent cx cx cx cx cx cx




Used to tx: cx cx




-Advanced prostate cancer cx cx




-female androgen excess syndrome cx cx cx cx




Adverse Effects in males cx cx cx




- gynecomastia
cx




-reversible liver toxicity cx cx cx




Black Box Warning cx cx




-hepatic failure cx




-hepatic encephalopathy cx cx




Basline/monthly liver function test for 1st 4 months cx cx cx cx cx cx cx




Spironolactone (Aldactone) - ansaldosterone antagonist cx cx cx cx




potassium sparing diuretic cx cx cx




used for tx: cx cx




-female hirsutism (abnormal growth of hair) cx cx cx cx cx




-acne cx




-relief of PMS/PMDD symptoms (25-50 mg/d)
cx cx cx cx cx




Adverse reactions cx




- dose related + reversible when discont.
cx cx cx cx cx cx




-GI upset cx




-Drowsiness cx




-Gynecomastia
-Impotence
-Cutaneous (skin) eruptions cx cx




- Urticaria
cx cx




Black Box Warning cx cx cx




Tumorigenicity in animals cx cx cx




Should not be used during pregnancy cx cx cx cx cx




Androgen - ansTestosterone cx cx cx




most important adrogen in humans
cx cx cx cx cx




levels remain stable at 55yr
cx cx cx cx cx




70 yrs men decrease in
cx cx cx cx cx




-strength, libido, muscle mass cx cx cx




Transdermal application of testosterone - ansPatch + gel cx cx cx cx cx cx cx




can be applied to intact nonscrotal skin
cx cx cx cx cx cx