NURS 5334 Quiz 2 – UTA Advanced Pharmacology |
40 Practice Questions with Verified Answers &
Rationales | 2026/2027 Update
Introduction
This comprehensive study guide for the University of Texas at Arlington NURS 5334
Advanced Pharmacology Quiz 2 includes 40 practice questions covering key topics tested
on the exam. The quiz focuses on antimicrobials, gastrointestinal drugs, women's health,
dermatology, and immunizations.
All answers are presented in bold italics with detailed rationales following each response.
Section 1: Antimicrobials (Questions 1–12)
Q1. What is the primary mechanism of action of beta-lactam antibiotics like
penicillin?
A) Inhibits protein synthesis
B) Inhibits cell wall synthesis
C) Alters DNA replication
D) Blocks folic acid synthesis
Answer: B – Inhibits cell wall synthesis
Beta-lactam antibiotics bind to and inactivate penicillin-binding proteins (PBPs), preventing
peptidoglycan cross-linking in bacterial cell walls. This leads to bacterial cell lysis and death.
Q2. Which generation of cephalosporins is most effective against Pseudomonas
aeruginosa?
A) First
B) Second
C) Third
D) Fourth
Answer: D – Fourth
, Fourth-generation cephalosporins like cefepime have enhanced activity against
gram-negative organisms including P. aeruginosa, with better penetration of the outer
membrane.
Q3. Vancomycin is the drug of choice for:
A) MRSA infections
B) VRE infections
C) UTI
D) Syphilis
Answer: A – MRSA infections
Vancomycin is a glycopeptide antibiotic that inhibits cell wall synthesis and is the first-line
treatment for methicillin-resistant Staphylococcus aureus (MRSA).
Q4. What is the primary toxicity concern with aminoglycosides?
A) Stevens-Johnson syndrome
B) Hepatotoxicity
C) Ototoxicity and nephrotoxicity
D) Anemia
Answer: C – Ototoxicity and nephrotoxicity
Aminoglycosides (gentamicin, tobramycin, amikacin) are associated with dose-dependent
nephrotoxicity and ototoxicity (vestibular and cochlear). Peak and trough monitoring is
required.
Q5. What mineral interactions reduce the absorption of tetracyclines?
A) Sodium
B) Potassium
C) Calcium, iron, magnesium
D) Phosphate
Answer: C – Calcium, iron, magnesium
Tetracyclines chelate divalent and trivalent cations, forming insoluble complexes that
prevent absorption. Patients should separate tetracycline dosing from dairy, antacids, and
iron supplements by 2–4 hours.
Q6. Macrolides can inhibit which hepatic enzyme system?
40 Practice Questions with Verified Answers &
Rationales | 2026/2027 Update
Introduction
This comprehensive study guide for the University of Texas at Arlington NURS 5334
Advanced Pharmacology Quiz 2 includes 40 practice questions covering key topics tested
on the exam. The quiz focuses on antimicrobials, gastrointestinal drugs, women's health,
dermatology, and immunizations.
All answers are presented in bold italics with detailed rationales following each response.
Section 1: Antimicrobials (Questions 1–12)
Q1. What is the primary mechanism of action of beta-lactam antibiotics like
penicillin?
A) Inhibits protein synthesis
B) Inhibits cell wall synthesis
C) Alters DNA replication
D) Blocks folic acid synthesis
Answer: B – Inhibits cell wall synthesis
Beta-lactam antibiotics bind to and inactivate penicillin-binding proteins (PBPs), preventing
peptidoglycan cross-linking in bacterial cell walls. This leads to bacterial cell lysis and death.
Q2. Which generation of cephalosporins is most effective against Pseudomonas
aeruginosa?
A) First
B) Second
C) Third
D) Fourth
Answer: D – Fourth
, Fourth-generation cephalosporins like cefepime have enhanced activity against
gram-negative organisms including P. aeruginosa, with better penetration of the outer
membrane.
Q3. Vancomycin is the drug of choice for:
A) MRSA infections
B) VRE infections
C) UTI
D) Syphilis
Answer: A – MRSA infections
Vancomycin is a glycopeptide antibiotic that inhibits cell wall synthesis and is the first-line
treatment for methicillin-resistant Staphylococcus aureus (MRSA).
Q4. What is the primary toxicity concern with aminoglycosides?
A) Stevens-Johnson syndrome
B) Hepatotoxicity
C) Ototoxicity and nephrotoxicity
D) Anemia
Answer: C – Ototoxicity and nephrotoxicity
Aminoglycosides (gentamicin, tobramycin, amikacin) are associated with dose-dependent
nephrotoxicity and ototoxicity (vestibular and cochlear). Peak and trough monitoring is
required.
Q5. What mineral interactions reduce the absorption of tetracyclines?
A) Sodium
B) Potassium
C) Calcium, iron, magnesium
D) Phosphate
Answer: C – Calcium, iron, magnesium
Tetracyclines chelate divalent and trivalent cations, forming insoluble complexes that
prevent absorption. Patients should separate tetracycline dosing from dairy, antacids, and
iron supplements by 2–4 hours.
Q6. Macrolides can inhibit which hepatic enzyme system?
