NR565 MIDTERM, WEEK 4 EXAM NEWEST 2025 COMPLETE QUESTIONS
AND CORRECT DETAILED ANSWERS (VERIFIED ANSWERS) |ALREADY
GRADED A+||BRAND NEW VERSION!!
What areas of healthcare most heavily integrate pharmacogenetics into clinical practice? -
DETAILED ANSWER-Oncology & cystic fibrosis population
Think HER2 with breast cancer and CF have 2 defective CFTR genes
Barrier in understanding racial differences in drug pharmacokinetics with American Indian or
Alaskan Natives? - DETAILED ANSWER-Limited to no research in racial considerations
Purpose of genetic testing with Tamoxifen? - DETAILED ANSWER-Reduce the risk of
therapeutic failure as variation of CYP2D6 will not allow for activation and conversion to
endoxifen which is necessary for treating estrogen sensitive cancers.
Liver and Kidney functions labs for monitoring? - DETAILED ANSWER-Creatinine, BUN, GFR,
AST, ALT, Bilirubin
Dose of propranolol in migraine reduction - DETAILED ANSWER-20-80mg 3-4X
daily increases levels of serotonin, prevents beta receptor vasodilation allow 4-6
weeks to trial treatment
, First consideration in selecting most appropriate beta blocker? - DETAILED ANSWER-Cardio
selectivity
Pregnancy Categories B vs D with beta blockers - DETAILED ANSWER-Atenolol - D
betaxolol, acebutolol, metoprolol, nadolol, nebivolol, tiolol, propranolol - C
Where are beta 2 receptors located and what do they do? - DETAILED ANSWER-
smooth muscle of eye, arterioles, venules, bronchioles, liver, pancreas, GI, GU Stimulate
adneylyl cyclase, increase cAMP, activate cardiac G1
Drug of choice for HTN with concomitant BPH - DETAILED ANSWER-Alpha 1 adrenergic
antagonist
Beta blockers that require dosage adjustment in patients with renal impairment - DETAILED
ANSWER-acebutolol, atenolol, nadolol, and nebivolol
Dosing schedule of donepizil - DETAILED ANSWER-5mg nightly at bedtime, increase at 4-6
week intervals, max dose is 10 mg daily.
what makes clopidogrel unique among other P2Y12 inhibitors? - DETAILED ANSWER-relies on
cytochrome P450 enzyme to convert into active metabolite (CYP2C19) thus requiring this gene
to be present to be an effective drug in clot formation
Alternatives to clopidogrel - DETAILED ANSWER-Brilinta (ticagrelor) or Effient (Prasugrel)
because they are not dependent on CYP2C19 genotype
Name the 4 medications that REQUIRE pharmacogenetic testing - DETAILED
ANSWERCetuximab, trastuzumab, maraviroc, dasatinib
AND CORRECT DETAILED ANSWERS (VERIFIED ANSWERS) |ALREADY
GRADED A+||BRAND NEW VERSION!!
What areas of healthcare most heavily integrate pharmacogenetics into clinical practice? -
DETAILED ANSWER-Oncology & cystic fibrosis population
Think HER2 with breast cancer and CF have 2 defective CFTR genes
Barrier in understanding racial differences in drug pharmacokinetics with American Indian or
Alaskan Natives? - DETAILED ANSWER-Limited to no research in racial considerations
Purpose of genetic testing with Tamoxifen? - DETAILED ANSWER-Reduce the risk of
therapeutic failure as variation of CYP2D6 will not allow for activation and conversion to
endoxifen which is necessary for treating estrogen sensitive cancers.
Liver and Kidney functions labs for monitoring? - DETAILED ANSWER-Creatinine, BUN, GFR,
AST, ALT, Bilirubin
Dose of propranolol in migraine reduction - DETAILED ANSWER-20-80mg 3-4X
daily increases levels of serotonin, prevents beta receptor vasodilation allow 4-6
weeks to trial treatment
, First consideration in selecting most appropriate beta blocker? - DETAILED ANSWER-Cardio
selectivity
Pregnancy Categories B vs D with beta blockers - DETAILED ANSWER-Atenolol - D
betaxolol, acebutolol, metoprolol, nadolol, nebivolol, tiolol, propranolol - C
Where are beta 2 receptors located and what do they do? - DETAILED ANSWER-
smooth muscle of eye, arterioles, venules, bronchioles, liver, pancreas, GI, GU Stimulate
adneylyl cyclase, increase cAMP, activate cardiac G1
Drug of choice for HTN with concomitant BPH - DETAILED ANSWER-Alpha 1 adrenergic
antagonist
Beta blockers that require dosage adjustment in patients with renal impairment - DETAILED
ANSWER-acebutolol, atenolol, nadolol, and nebivolol
Dosing schedule of donepizil - DETAILED ANSWER-5mg nightly at bedtime, increase at 4-6
week intervals, max dose is 10 mg daily.
what makes clopidogrel unique among other P2Y12 inhibitors? - DETAILED ANSWER-relies on
cytochrome P450 enzyme to convert into active metabolite (CYP2C19) thus requiring this gene
to be present to be an effective drug in clot formation
Alternatives to clopidogrel - DETAILED ANSWER-Brilinta (ticagrelor) or Effient (Prasugrel)
because they are not dependent on CYP2C19 genotype
Name the 4 medications that REQUIRE pharmacogenetic testing - DETAILED
ANSWERCetuximab, trastuzumab, maraviroc, dasatinib
