Actual Exam 2026/2027 Complete Questions and
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Question 1
A 72-year-old male with heart failure presents with
worsening dyspnea, orthopnea, and 3+ pitting edema in
both lower extremities. Vital signs: BP 110/70, HR 95, RR
24, O2 92% on room air. Which medication is most likely
to improve his symptoms and reduce hospitalizations?
A. Metoprolol succinate
B. Furosemide
C. Digoxin
D. Hydralazine
Answer: B – Furosemide
Rationale: Loop diuretics (furosemide) rapidly reduce
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,preload and relieve pulmonary congestion and edema in
acute exacerbation of HF. Metoprolol is long-term but not
acute. Digoxin is for refractory or AF with RVR.
Category: Cardiology / Pharmacology
Question 2
A 45-year-old female presents with fatigue, cold
intolerance, weight gain, and constipation. Labs: TSH 12.5
mIU/mL (0.4–4.0), free T4 0.6 ng/dL (0.8–1.8). What is
the standard of care treatment?
A. Methimazole
B. Levothyroxine 1.6 mcg/kg/day
C. Liothyronine (T3) alone
D. Radioactive iodine ablation
Answer: B – Levothyroxine 1.6 mcg/kg/day
Rationale: Overt hypothyroidism requires levothyroxine
monotherapy, starting ~1.6 mcg/kg/day. T3 alone
causes peaks/troughs. Methimazole and RAI treat
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,hyperthyroidism.
Category: Endocrinology
Question 3
A 30-year-old male has acute onset of severe, sharp left-
sided chest pain that worsens with inspiration and
improves leaning forward. He has a fever and a friction
rub on auscultation. EKG shows diffuse ST elevations.
What is the most appropriate next step?
A. High-dose NSAIDs
B. Emergent coronary angiography
C. Thrombolytics
D. IV heparin
Answer: A – High-dose NSAIDs
Rationale: Classic for acute pericarditis (pleuritic pain, rub,
diffuse ST elevations, relieved by leaning forward). First-
line: NSAIDs (ibuprofen or aspirin). No indication for cath,
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, thrombolytics, or heparin.
Category: Cardiology
Question 4
A 65-year-old with type 2 DM, CKD stage 3 (eGFR 45),
and hypertension has a BP of 148/88 mmHg on lisinopril
20 mg daily. Which is the best next antihypertensive to
add?
A. Amlodipine
B. Hydrochlorothiazide
C. Spironolactone
D. Metoprolol
Answer: A – Amlodipine
Rationale: In DM + CKD, first-line: ACEi or ARB. If goal
not met, add CCB (amlodipine) or thiazide-like diuretic.
HCTZ ineffective at eGFR <45. Spironolactone risk of
hyperkalemia with ACEi.
Category: Nephrology / Pharmacology
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