Exam Questions and Correct
Answers | New Update
prostacyclin derivatives, endothelin antagonists, activators of soluble
guanylate cyclase, PDE5 inhibitors - ANSWER ✔✔drugs used to
treat PAH
Uptravi - ANSWER ✔✔prostacyclin derivative
MOA of Uptravi - ANSWER ✔✔vasodilation, antiproliferative, inhibit
platelet aggregation, antithrombotic, anti-inflammatory
bosentan, sitaxentan, ambrisentan (Letairis) - ANSWER
✔✔endothelin antagonists
,MOA of endothelin antagonists - ANSWER ✔✔block endothelin A
receptor, leading to vasodilation
cinaciguat, riociguat - ANSWER ✔✔activators of soluble guanylate
cyclase
MOA of activators of soluble guanylate cyclase - ANSWER
✔✔stimulator of sGC, elevates nitric oxide, causing vasodilation
Viagra, Cialis - ANSWER ✔✔PDE5 ihibitors
MOA of PDE5 inhibitors - ANSWER ✔✔inhibit PDE5, increase cGMP
levels
ivacaftor, tezcaftor, lumacaftor - ANSWER ✔✔drugs used to treat CF
MOA of ivacaftor - ANSWER ✔✔potentiator of CFTR
MOA of tezcaftor - ANSWER ✔✔repairs misfolded components of
CFTR
MOA of lumacaftor - ANSWER ✔✔"chaperone" function prevents
misfolding of CFTR proteins
phosphodiesterase inhibitors, anticholinergics - ANSWER ✔✔drugs
used to treat COPD
,roflumilast (Daliresp), cilomilast - ANSWER ✔✔PDE4 inhibitors
theophylline - ANSWER ✔✔nonselective PDE inhibitor
MOA of phosphodiesterase inhibitors - ANSWER ✔✔anti-
inflammatory actions
MOA of roflumilast - ANSWER ✔✔weak bronchodilators that reduce
inflammation, crosses BBB
MOA of cilomilast - ANSWER ✔✔more powerful anti-inflammatory
than roflumilast, does not cross BBB
tiotropium (Spiriva), Tuzadora, revefenacin - ANSWER
✔✔anticholinergics
MOA of anticholinergics - ANSWER ✔✔bind to M3 receptor, causing
mild bronchodilation and mucus volume reduction
codeine, benzonatate, tetracaine, dextromethorphan - ANSWER
✔✔antitussives
MOA of codeine - ANSWER ✔✔work in the brain to suppress cough
MOA of benzonatate and tetracaine (local anesthetics) - ANSWER
✔✔locally anesthetizes C fibers, blocks voltage gated sodium channels
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, MOA of dextromethorphan - ANSWER ✔✔opiate agonist and NMDA
antagonist
What drug does not cause false positives for opiates but will cause false
positives for PCP? - ANSWER ✔✔dextromethorphan
uses of antihistamines - ANSWER ✔✔hay fever, allergic rhinitis,
eczema, allergic conjunctivitis, sneezing, urticaria, allergic reactions
caused by food allergies, insomnia, motion sickness, Parkinson's
diphenhydramine (Benadryl), dimenhydrinate, doxylamine,
carbinoxamine - ANSWER ✔✔ethanolamine antihistamines
Which antihistamines have the highest antimuscarinic/anticholinergic
potential and have the greatest risk of sleepiness? - ANSWER
✔✔ethanolamine antihistamines
uses of diphenhydramine (Benadryl) - ANSWER ✔✔insomnia, motion
sickness, Parkinson's
Which drug is both an ethanolamine antihistamine and 1st generation
antihistamine? - ANSWER ✔✔diphenhydramine
True/False: 1st generation antihistamines do not cross the BBB. -
ANSWER ✔✔False, 1st generation antihistamines cross the BBB.