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PHM 104 Final Exam Study Guide (2026) | 500+ Practice Questions & Correct Answers | Pharmacology, Respiratory Drugs, Endocrine Pharmacology, Psychiatry & Diabetes Medications

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Prepare for the PHM 104 Final Exam with this comprehensive 2026 study guide, featuring 500+ exam-style practice questions with correct answers and detailed rationales covering the essential principles of cardiovascular pharmacology, respiratory pharmacology, endocrine pharmacology, psychiatric medications, diabetes management, and autonomic pharmacology. Designed for pharmacy, pharmacology, nursing, physician assistant, and other health sciences students, this resource strengthens drug classification, mechanisms of action, therapeutic uses, adverse effects, contraindications, and clinical decision-making while preparing learners for final examinations, professional coursework, and board-style assessments. The questions closely reflect the scope and complexity of PHM 104 examinations, making this guide an excellent review resource for mastering core pharmacologic concepts. This study guide provides comprehensive coverage of respiratory and pulmonary pharmacology, including pulmonary arterial hypertension (PAH) therapies, prostacyclin derivatives, endothelin receptor antagonists, soluble guanylate cyclase stimulators, phosphodiesterase-5 (PDE5) inhibitors, cystic fibrosis medications, CFTR modulators, chronic obstructive pulmonary disease (COPD) pharmacotherapy, phosphodiesterase-4 inhibitors, anticholinergics, beta-2 agonists (SABA, LABA, and ultra-LABA), inhaled corticosteroids, antitussives, mucolytics, antihistamines, alpha-adrenergic agonists, bronchodilators, leukotriene-related therapies, magnesium, omalizumab, terbutaline, cough suppression, allergic rhinitis, motion sickness, nasal decongestants, asthma management, respiratory inflammation, and pulmonary drug mechanisms of action. Each verified answer reinforces medication classifications, therapeutic applications, adverse reactions, and evidence-based pharmacologic management of respiratory diseases. The guide also delivers extensive review of endocrine, metabolic, musculoskeletal, and psychiatric pharmacology, including insulin therapy, rapid-, short-, intermediate-, and long-acting insulin preparations, oral antihyperglycemic agents, metformin, sulfonylureas, meglitinides, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors, thiazolidinediones (TZDs), diabetes mellitus pathophysiology, diabetic pharmacotherapy, hypothyroidism, hyperthyroidism, levothyroxine, methimazole, propylthiouracil, thyroid hormone regulation, osteoporosis medications, bisphosphonates, denosumab, raloxifene, teriparatide, abaloparatide, romosozumab, calcitonin, schizophrenia pharmacotherapy, first- and second-generation antipsychotics, extrapyramidal symptoms (EPS), tardive dyskinesia, depression, selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), tetracyclic antidepressants (TeCAs), benzodiazepines, hypnotics, sedatives, ADHD medications, stimulants, atomoxetine, bipolar disorder treatment, lithium, anticonvulsants, mood stabilizers, pharmacologic mechanisms, adverse drug reactions, contraindications, and clinical therapeutics. The study guide integrates pharmacodynamics, pharmacokinetics, receptor pharmacology, evidence-based prescribing principles, and examination-focused clinical scenarios to prepare students for academic success and professional healthcare practice. This study guide is ideal for PHM 104 students, pharmacy students, pharmacology students, Doctor of Pharmacy (PharmD) students, nursing students, physician assistant (PA) students, medical students, biomedical sciences students, pharmaceutical sciences students, allied health students, and learners preparing for pharmacology examinations and healthcare professional licensing assessments. The content aligns with leading pharmacology references and evidence-based clinical guidelines, including: Brunton, L. L., Hilal-Dandan, R., & Knollmann, B. C. Goodman & Gilman's The Pharmacological Basis of Therapeutics. McGraw-Hill. Katzung, B. G., & Vanderah, T. W. Basic & Clinical Pharmacology. McGraw-Hill. DiPiro, J. T., Yee, G. C., Posey, L. M., Haines, S. T., Nolin, T. D., & Ellingrod, V. Pharmacotherapy: A Pathophysiologic Approach. McGraw-Hill. Rang, H. P., Ritter, J. M., Flower, R. J., & Henderson, G. Rang & Dale's Pharmacology. Elsevier. Lexicomp Drug Information Handbook. Wolters Kluwer. U.S. Food and Drug Administration (FDA). Drug Safety Communications and Prescribing Information. American Diabetes Association (ADA). Standards of Care in Diabetes. Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global Strategy for the Diagnosis, Management, and Prevention of COPD. Relevant students: PHM 104 Students, Pharmacology Students, Pharmacy Students, Doctor of Pharmacy (PharmD) Students, Nursing Students, Medical Students, Physician Assistant (PA) Students, Biomedical Sciences Students, Pharmaceutical Sciences Students, Allied Health Students, Healthcare Students, Pharmacology Exam Candidates. Keywords PHM 104, PHM 104 Final Exam, Pharmacology, Respiratory Pharmacology, Pulmonary Hypertension, PAH, COPD, Asthma, Bronchodilators, Beta 2 Agonists, SABA, LABA, Corticosteroids, Antihistamines, Antitussives, Mucolytics, Alpha Agonists, PDE5 Inhibitors, Endothelin Receptor Antagonists, Cystic Fibrosis, CFTR Modulators, Diabetes Mellitus, Insulin Therapy, Metformin, Sulfonylureas, GLP 1 Agonists, DPP 4 Inhibitors, SGLT2 Inhibitors, Thiazolidinediones, Thyroid Pharmacology, Levothyroxine, Methimazole, Propylthiouracil, Osteoporosis Drugs, Bisphosphonates, Denosumab, Schizophrenia, Antipsychotics, SSRIs, SNRIs, TCAs, MAOIs, ADHD Medications, Stimulants, Atomoxetine, Bipolar Disorder, Lithium, Benzodiazepines, Sedatives, Hypnotics, Drug Mechanisms, Pharmacodynamics, Pharmacokinetics, Pharmacy Exam Questions, Correct Answers, Study Guide

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PHM 104
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PHM 104 Final Exam 2026
Exam Questions and Correct
Answers | New Update



prostacyclin derivatives, endothelin antagonists, activators of soluble

guanylate cyclase, PDE5 inhibitors - ANSWER ✔✔drugs used to

treat PAH


Uptravi - ANSWER ✔✔prostacyclin derivative


MOA of Uptravi - ANSWER ✔✔vasodilation, antiproliferative, inhibit

platelet aggregation, antithrombotic, anti-inflammatory


bosentan, sitaxentan, ambrisentan (Letairis) - ANSWER

✔✔endothelin antagonists

,MOA of endothelin antagonists - ANSWER ✔✔block endothelin A

receptor, leading to vasodilation


cinaciguat, riociguat - ANSWER ✔✔activators of soluble guanylate

cyclase


MOA of activators of soluble guanylate cyclase - ANSWER

✔✔stimulator of sGC, elevates nitric oxide, causing vasodilation


Viagra, Cialis - ANSWER ✔✔PDE5 ihibitors


MOA of PDE5 inhibitors - ANSWER ✔✔inhibit PDE5, increase cGMP

levels


ivacaftor, tezcaftor, lumacaftor - ANSWER ✔✔drugs used to treat CF


MOA of ivacaftor - ANSWER ✔✔potentiator of CFTR


MOA of tezcaftor - ANSWER ✔✔repairs misfolded components of

CFTR


MOA of lumacaftor - ANSWER ✔✔"chaperone" function prevents

misfolding of CFTR proteins


phosphodiesterase inhibitors, anticholinergics - ANSWER ✔✔drugs

used to treat COPD

,roflumilast (Daliresp), cilomilast - ANSWER ✔✔PDE4 inhibitors


theophylline - ANSWER ✔✔nonselective PDE inhibitor


MOA of phosphodiesterase inhibitors - ANSWER ✔✔anti-

inflammatory actions


MOA of roflumilast - ANSWER ✔✔weak bronchodilators that reduce

inflammation, crosses BBB


MOA of cilomilast - ANSWER ✔✔more powerful anti-inflammatory

than roflumilast, does not cross BBB


tiotropium (Spiriva), Tuzadora, revefenacin - ANSWER

✔✔anticholinergics


MOA of anticholinergics - ANSWER ✔✔bind to M3 receptor, causing

mild bronchodilation and mucus volume reduction


codeine, benzonatate, tetracaine, dextromethorphan - ANSWER

✔✔antitussives


MOA of codeine - ANSWER ✔✔work in the brain to suppress cough


MOA of benzonatate and tetracaine (local anesthetics) - ANSWER

✔✔locally anesthetizes C fibers, blocks voltage gated sodium channels

3
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, MOA of dextromethorphan - ANSWER ✔✔opiate agonist and NMDA

antagonist

What drug does not cause false positives for opiates but will cause false

positives for PCP? - ANSWER ✔✔dextromethorphan


uses of antihistamines - ANSWER ✔✔hay fever, allergic rhinitis,

eczema, allergic conjunctivitis, sneezing, urticaria, allergic reactions

caused by food allergies, insomnia, motion sickness, Parkinson's

diphenhydramine (Benadryl), dimenhydrinate, doxylamine,

carbinoxamine - ANSWER ✔✔ethanolamine antihistamines


Which antihistamines have the highest antimuscarinic/anticholinergic

potential and have the greatest risk of sleepiness? - ANSWER

✔✔ethanolamine antihistamines


uses of diphenhydramine (Benadryl) - ANSWER ✔✔insomnia, motion

sickness, Parkinson's

Which drug is both an ethanolamine antihistamine and 1st generation

antihistamine? - ANSWER ✔✔diphenhydramine


True/False: 1st generation antihistamines do not cross the BBB. -

ANSWER ✔✔False, 1st generation antihistamines cross the BBB.

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