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1. _________ developmental stage in utero is from con- pre-embryonic
ception to day 14.
2. _________ developmental stage in utero is from day 15 embryonic
to the end of week 8.
3. _________ developmental stage in utero is from week fetal
8 to birth.
4. During what developmental stage does the forma- embryonic (b/w day 15 &
tion of the nervous system occur? week 8)
5. When does neural tube formation occur? days 18-26
6. When does brain formation start in utero? day 28
7. Why is it important to start taking folic acid supple- neural tube formation oc-
ments before getting pregnant? curs days 18-26
(most women do not even
know they preggies)
if women has folic acid def
= potential neural tube de-
fects
8. What cell lines make up the ectoderm? neurons of brain
skin cells of epidermis
pigment cells
9. What are the 3 embryonic cell layers from external --> External = ectoderm
internal?
Middle = mesoderm
, Neuroanatomy Exam 1
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Internal = endoderm
10. True/False true
The CNS arises from ectodermal cells that fold to
form the neural tube.
11. Once the neural tube closes, ______ formation begins brain
on day 28.
12. What are the 3 main divisions of the developing forebrain (prosen-
brain? cephalon)
midbrain (mesen-
cephalon)
hindbrain (rhomben-
cephalon)
13. What is the largest part of the nervous system? forebrain
14. What is contained w/in the forebrain? cerebral cortex
subcortical white matter
basal ganglia
thalamus
hypothalamus
15. The ________ connects the forebrain to the hindbrain. midbrain
16. The midbrain is involved in __________ & ___________ auditory & visual
processing.
, Neuroanatomy Exam 1
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17. The __________ is the connection between the brain & hindbrain
spinal cord.
18. What part of the brain coordinates autonomic func- C - Hindbrain
tions?
A - Forebrain
B - Midbrain
C - Hindbrain
D - Frontal lobe
19. What structures are included in the hindbrain? medulla
pons
cerebellum
20. The anteromedial part of the somite becomes _______ vertebrae & skull (sclero-
& _______. tome)
21. The posteromedial part of the somite becomes the skeletal muscle (myotome)
___________.
22. The lateral part of the somite becomes ____________. dermis (dermatome)
23. At birth, where does the spinal cord end? ~ L3
24. As an adult, where does the spinal cord end? ~ L1-L2
25. True/False true
Neurons differentiate after migrating to their final
location.
26. in 4th fetal month
, Neuroanatomy Exam 1
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When does myelination begin in cellular develop-
ment?
27. Most myelin sheaths are completed by what age? by end of 3rd yr of life
28. What are the 2 types of cells that make myelin? CNS --> Oligodendrocytes
PNS --> Schwann Cells
29. When do major deformities of the nervous system BEFORE week 20
occur in utero?
30. When is the CNS most susceptible to major malfor- between day 14 & week 20
mations in utero?
31. _____________ is when the forebrain (prosencephalon) holoprosencephaly
does not divide into 2 cerebral hemispheres, result-
ing in a single cerebral hemisphere.
**compatible w life, but
most dead by age 3**
32. ___________ is formation of rudimentary brainstem anencephaly
w/out cerebral & cerebellar hemispheres. (aka no
brain)
33. Why can pts w anencephaly survive til birth +/- a few they have developed brain-
days? stem which allows for HR &
breathing ... just not sus-
tainable beyond a couple of
days
34. _____________ malformation is a developmental defor- chiari
mity of the posterior fossa & hindbrain.
35.