USMLE STEP 1
OBJECTIVE ASSESSMENT - EXAM
NBME CBSE REAL EXAM 200
QUESTIONS AND ANSWERS
LATEST 2025 COMPLETE EXAM
(usmle step 1) MEDICAL
EXAMINATION
Board Exam
200 100% 2025
QUESTIONS VERIFIED ANSWERS EDITION
TOPICS COVERED
Pathology & Pathophysiology Physiology
Pharmacology Biochemistry & Genetics
Anatomy & Embryology Microbiology & Immunology
COVER PAGE - 1
, SECTION 1 | General Principles | NBME CBSE REAL EXAM 200 QUESTIONS AND ANSWERS LATEST 2025 C
Q1 Question 1 of 200
Q1. A 57-year-old man comes to the clinic presenting with symptoms characteristic of Gaucher
disease. Which of the following is the most likely diagnosis?
A. A separate idiopathic process
B. Gaucher disease
C. Niemann-Pick disease
D. An unrelated genetic condition
Correct Answer: B
Rationale:
The patient's presentation is classic for Gaucher disease. The symptoms do not align with
Niemann-Pick disease.
Q2 Question 2 of 200
Q2. A 57-year-old man is evaluated and diagnosed with Gaucher disease. Which of the
following best describes the underlying mechanism?
A. Unrelated pathology
B. Glucocerebrosidase deficiency
C. Alternative false mechanism
D. Sphingomyelinase deficiency
Correct Answer: B
Rationale:
The mechanism of Gaucher disease is Glucocerebrosidase deficiency.
E REAL EXAM 200 QUESTIONS AND ANSWERS LATEST 2025 COMPLETE EXAM (usmle step 1) MEDICAL EXAMINATION - 2025 | Passing Score: 75
, Q3 Question 3 of 200
Q3. A 57-year-old man with Gaucher disease requires management. Which of the following is
the most appropriate next step?
A. Surgical excision if not primary
B. Enzyme replacement
C. Observation
D. Broad-spectrum antibiotics
Correct Answer: B
Rationale:
The most appropriate treatment for Gaucher disease is Enzyme replacement.
Q4 Question 4 of 200
Q4. A 57-year-old man presents with signs of Gaucher disease. Which of the following
laboratory or imaging findings is most expected?
A. A non-specific false positive
B. Lipid-laden macrophages
C. Normal findings expected
D. An unrelated lab result
Correct Answer: B
Rationale:
Gaucher disease characteristically shows Lipid-laden macrophages on evaluation.
E REAL EXAM 200 QUESTIONS AND ANSWERS LATEST 2025 COMPLETE EXAM (usmle step 1) MEDICAL EXAMINATION - 2025 | Passing Score: 75
, Q5 Question 5 of 200
Q5. A 36-year-old man comes to the clinic presenting with symptoms characteristic of Familial
hypercholesterolemia. Which of the following is the most likely diagnosis?
A. An unrelated genetic condition
B. A separate idiopathic process
C. Familial hypercholesterolemia
D. Gout
Correct Answer: C
Rationale:
The patient's presentation is classic for Familial hypercholesterolemia. The symptoms do not align with
Gout.
Q6 Question 6 of 200
Q6. A 36-year-old man is evaluated and diagnosed with Familial hypercholesterolemia. Which of
the following best describes the underlying mechanism?
A. Unrelated pathology
B. LPL deficiency
C. Defective LDL receptor
D. Alternative false mechanism
Correct Answer: C
Rationale:
The mechanism of Familial hypercholesterolemia is Defective LDL receptor.
E REAL EXAM 200 QUESTIONS AND ANSWERS LATEST 2025 COMPLETE EXAM (usmle step 1) MEDICAL EXAMINATION - 2025 | Passing Score: 75
OBJECTIVE ASSESSMENT - EXAM
NBME CBSE REAL EXAM 200
QUESTIONS AND ANSWERS
LATEST 2025 COMPLETE EXAM
(usmle step 1) MEDICAL
EXAMINATION
Board Exam
200 100% 2025
QUESTIONS VERIFIED ANSWERS EDITION
TOPICS COVERED
Pathology & Pathophysiology Physiology
Pharmacology Biochemistry & Genetics
Anatomy & Embryology Microbiology & Immunology
COVER PAGE - 1
, SECTION 1 | General Principles | NBME CBSE REAL EXAM 200 QUESTIONS AND ANSWERS LATEST 2025 C
Q1 Question 1 of 200
Q1. A 57-year-old man comes to the clinic presenting with symptoms characteristic of Gaucher
disease. Which of the following is the most likely diagnosis?
A. A separate idiopathic process
B. Gaucher disease
C. Niemann-Pick disease
D. An unrelated genetic condition
Correct Answer: B
Rationale:
The patient's presentation is classic for Gaucher disease. The symptoms do not align with
Niemann-Pick disease.
Q2 Question 2 of 200
Q2. A 57-year-old man is evaluated and diagnosed with Gaucher disease. Which of the
following best describes the underlying mechanism?
A. Unrelated pathology
B. Glucocerebrosidase deficiency
C. Alternative false mechanism
D. Sphingomyelinase deficiency
Correct Answer: B
Rationale:
The mechanism of Gaucher disease is Glucocerebrosidase deficiency.
E REAL EXAM 200 QUESTIONS AND ANSWERS LATEST 2025 COMPLETE EXAM (usmle step 1) MEDICAL EXAMINATION - 2025 | Passing Score: 75
, Q3 Question 3 of 200
Q3. A 57-year-old man with Gaucher disease requires management. Which of the following is
the most appropriate next step?
A. Surgical excision if not primary
B. Enzyme replacement
C. Observation
D. Broad-spectrum antibiotics
Correct Answer: B
Rationale:
The most appropriate treatment for Gaucher disease is Enzyme replacement.
Q4 Question 4 of 200
Q4. A 57-year-old man presents with signs of Gaucher disease. Which of the following
laboratory or imaging findings is most expected?
A. A non-specific false positive
B. Lipid-laden macrophages
C. Normal findings expected
D. An unrelated lab result
Correct Answer: B
Rationale:
Gaucher disease characteristically shows Lipid-laden macrophages on evaluation.
E REAL EXAM 200 QUESTIONS AND ANSWERS LATEST 2025 COMPLETE EXAM (usmle step 1) MEDICAL EXAMINATION - 2025 | Passing Score: 75
, Q5 Question 5 of 200
Q5. A 36-year-old man comes to the clinic presenting with symptoms characteristic of Familial
hypercholesterolemia. Which of the following is the most likely diagnosis?
A. An unrelated genetic condition
B. A separate idiopathic process
C. Familial hypercholesterolemia
D. Gout
Correct Answer: C
Rationale:
The patient's presentation is classic for Familial hypercholesterolemia. The symptoms do not align with
Gout.
Q6 Question 6 of 200
Q6. A 36-year-old man is evaluated and diagnosed with Familial hypercholesterolemia. Which of
the following best describes the underlying mechanism?
A. Unrelated pathology
B. LPL deficiency
C. Defective LDL receptor
D. Alternative false mechanism
Correct Answer: C
Rationale:
The mechanism of Familial hypercholesterolemia is Defective LDL receptor.
E REAL EXAM 200 QUESTIONS AND ANSWERS LATEST 2025 COMPLETE EXAM (usmle step 1) MEDICAL EXAMINATION - 2025 | Passing Score: 75
