Explain how scaffolding proteins help to coordinate a cell's response to incoming
signals.
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bind to each individual kinase such that they are spatially organized for
optimal function
A largely relay proteins to which can increase the signal transduction
efficiency.
Explain how steroid hormone receptors can affect transcription.
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, interaction with coactivators
-non-polar structure allows steroids to easily cross the membrane where
they bind to a receptor in the cytoplasm
-steroid hormone receptors= primary function is to act as regulators of
gene expression
-all receptors have similar structures; this makes them part of the nuclear
receptor superfamily
-3 functional domains:
(1) a hormone-binding domain
(2) a DNA-binding domain
(3) a domain that can interact with co-activators to affect the level of gene
transcription
-when its inactive, it cannot bind to DNA (inhibitor protein is on the binding
site)
-signal molecule binds to the hormone-binding site, the shape
(conformation) changes, releasing the inhibitor and exposing the DNA-
binding site
-this binding actives particular genes
Which of the following statements about paracrine signals is most accurate?
A.They are long-lived with widespread effects
B.They are short-lived with widespread effects
C.They are long-lived with local effects
D.They are short-lived with local effect
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D.They are short-lived with local effects
Differentiate between different receptor types based on their cellular location
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signals.
Give this one a try later!
bind to each individual kinase such that they are spatially organized for
optimal function
A largely relay proteins to which can increase the signal transduction
efficiency.
Explain how steroid hormone receptors can affect transcription.
Give this one a try later!
, interaction with coactivators
-non-polar structure allows steroids to easily cross the membrane where
they bind to a receptor in the cytoplasm
-steroid hormone receptors= primary function is to act as regulators of
gene expression
-all receptors have similar structures; this makes them part of the nuclear
receptor superfamily
-3 functional domains:
(1) a hormone-binding domain
(2) a DNA-binding domain
(3) a domain that can interact with co-activators to affect the level of gene
transcription
-when its inactive, it cannot bind to DNA (inhibitor protein is on the binding
site)
-signal molecule binds to the hormone-binding site, the shape
(conformation) changes, releasing the inhibitor and exposing the DNA-
binding site
-this binding actives particular genes
Which of the following statements about paracrine signals is most accurate?
A.They are long-lived with widespread effects
B.They are short-lived with widespread effects
C.They are long-lived with local effects
D.They are short-lived with local effect
Give this one a try later!
D.They are short-lived with local effects
Differentiate between different receptor types based on their cellular location
Give this one a try later!
