NR449 Exam Prep 2026 | Chamberlain University
Evidence-Based Practice (EBP) Complete Study
Guide with Actual Complete Questions, Correct
Verified Answers and Detailed Rationales Already
Graded A+ | 2026 Updated
Master your Chamberlain NR449 Evidence-Based Practice exam with this comprehensive study
toolkit. Packed with 120 high-yield, practice-proven multiple-choice questions, detailed
correct-answer rationales, and complete core content breakdowns. Built strictly around Edapt
modules and the CJE Benchmark blueprint, this guide simplifies complex concepts like PICO
frameworks, variable identification, Belmont Report ethics, internal validity threats, p -values,
and levels of evidence. Perfect for quick reviews!
,Question 1
A nurse researcher is designing a study to measure the impact of an electronic medical record
prompt on hand hygiene compliance. Which of the following components represents the
independent variable?
• A) The rate of hand hygiene compliance
• B) The clinical nursing staff members
• C) The electronic medical record prompt
• D) The type of hand sanitizing solution used
• Rationale: The independent variable is the intervention, treatment, or
condition that is introduced or manipulated by the researcher to see if it
causes a change.
Question 2
A nurse is formulating a PICO question regarding the use of chlorhexidine vs. soap and water to
reduce central line-associated bloodstream infections (CLABSIs). In this clinical question, what
does the use of soap and water represent?
• A) Population (P)
• B) Intervention (I)
• C) Comparison (C)
• D) Outcome (O)
• Rationale: Soap and water serve as the standard or alternative practice
against which the new intervention (chlorhexidine) is being compared.
Question 3
Which ethical principle from the Belmont Report is violated if a researcher selects participants
entirely from a vulnerable population, such as low-income clinic patients, simply because they
are easily accessible?
• A) Beneficence
• B) Justice
• C) Respect for Persons
, • D) Autonomy
• Rationale: The principle of justice requires the fair and equitable
distribution of the burdens and benefits of research, meaning vulnerable
groups must not be exploited for convenience.
Question 4
A nursing research study reports a p-value of 0.01 regarding the effectiveness of a new pressure
injury prevention protocol. How should the nurse interpret this finding?
• A) The results have low clinical significance.
• B) There is a 10% chance the findings are accidental.
• C) The results are statistically significant.
• D) The protocol has a high risk of a Type I error.
• Rationale: A p-value of less than or equal to 0.05 indicates statistical
significance, meaning there is less than a 5% probability (1% in this case)
that the results occurred by chance.
Question 5
A nurse is reading a qualitative study that explores the lived experiences of parents grieving the
loss of a child in the neonatal intensive care unit. Which research design is being utilized?
• A) Grounded theory
• B) Phenomenology
• C) Ethnography
• D) Historical design
• Rationale: Phenomenological research focuses specifically on
understanding the lived experiences of individuals experiencing a specific
concept or phenomenon.
Question 6
During a longitudinal study on nursing burnout, several participants relocate or leave the
profession, dropping out of the study before final data collection. This represents which threat
to internal validity?
, • A) Maturation
• B) Testing effect
• C) Selection bias
• D) Attrition
• Rationale: Attrition (or mortality) occurs when the loss of subjects over
time threatens to bias or invalidate the final study findings. [1]
Question 7
A researcher rejects the null hypothesis when, in reality, no true difference or effect exists in the
population. What has occurred?
• A) Type I error
• B) Type II error
• C) Random sampling error
• D) High internal validity
• Rationale: A Type I error is a false positive, occurring when a researcher
concludes an effect exists when it actually does not.
Question 8
Which of the following documents serves as the regulatory body within an institution to review
research proposals, ensuring human subjects are protected from harm?
• A) National League for Nursing (NLN)
• B) American Nurses Association (ANA)
• C) Institutional Review Board (IRB)
• D) Quality and Safety Education for Nurses (QSEN)
• Rationale: The primary purpose of an IRB is to review research protocols
involving human participants to guarantee ethical standards are
maintained.
Question 9
Evidence-Based Practice (EBP) Complete Study
Guide with Actual Complete Questions, Correct
Verified Answers and Detailed Rationales Already
Graded A+ | 2026 Updated
Master your Chamberlain NR449 Evidence-Based Practice exam with this comprehensive study
toolkit. Packed with 120 high-yield, practice-proven multiple-choice questions, detailed
correct-answer rationales, and complete core content breakdowns. Built strictly around Edapt
modules and the CJE Benchmark blueprint, this guide simplifies complex concepts like PICO
frameworks, variable identification, Belmont Report ethics, internal validity threats, p -values,
and levels of evidence. Perfect for quick reviews!
,Question 1
A nurse researcher is designing a study to measure the impact of an electronic medical record
prompt on hand hygiene compliance. Which of the following components represents the
independent variable?
• A) The rate of hand hygiene compliance
• B) The clinical nursing staff members
• C) The electronic medical record prompt
• D) The type of hand sanitizing solution used
• Rationale: The independent variable is the intervention, treatment, or
condition that is introduced or manipulated by the researcher to see if it
causes a change.
Question 2
A nurse is formulating a PICO question regarding the use of chlorhexidine vs. soap and water to
reduce central line-associated bloodstream infections (CLABSIs). In this clinical question, what
does the use of soap and water represent?
• A) Population (P)
• B) Intervention (I)
• C) Comparison (C)
• D) Outcome (O)
• Rationale: Soap and water serve as the standard or alternative practice
against which the new intervention (chlorhexidine) is being compared.
Question 3
Which ethical principle from the Belmont Report is violated if a researcher selects participants
entirely from a vulnerable population, such as low-income clinic patients, simply because they
are easily accessible?
• A) Beneficence
• B) Justice
• C) Respect for Persons
, • D) Autonomy
• Rationale: The principle of justice requires the fair and equitable
distribution of the burdens and benefits of research, meaning vulnerable
groups must not be exploited for convenience.
Question 4
A nursing research study reports a p-value of 0.01 regarding the effectiveness of a new pressure
injury prevention protocol. How should the nurse interpret this finding?
• A) The results have low clinical significance.
• B) There is a 10% chance the findings are accidental.
• C) The results are statistically significant.
• D) The protocol has a high risk of a Type I error.
• Rationale: A p-value of less than or equal to 0.05 indicates statistical
significance, meaning there is less than a 5% probability (1% in this case)
that the results occurred by chance.
Question 5
A nurse is reading a qualitative study that explores the lived experiences of parents grieving the
loss of a child in the neonatal intensive care unit. Which research design is being utilized?
• A) Grounded theory
• B) Phenomenology
• C) Ethnography
• D) Historical design
• Rationale: Phenomenological research focuses specifically on
understanding the lived experiences of individuals experiencing a specific
concept or phenomenon.
Question 6
During a longitudinal study on nursing burnout, several participants relocate or leave the
profession, dropping out of the study before final data collection. This represents which threat
to internal validity?
, • A) Maturation
• B) Testing effect
• C) Selection bias
• D) Attrition
• Rationale: Attrition (or mortality) occurs when the loss of subjects over
time threatens to bias or invalidate the final study findings. [1]
Question 7
A researcher rejects the null hypothesis when, in reality, no true difference or effect exists in the
population. What has occurred?
• A) Type I error
• B) Type II error
• C) Random sampling error
• D) High internal validity
• Rationale: A Type I error is a false positive, occurring when a researcher
concludes an effect exists when it actually does not.
Question 8
Which of the following documents serves as the regulatory body within an institution to review
research proposals, ensuring human subjects are protected from harm?
• A) National League for Nursing (NLN)
• B) American Nurses Association (ANA)
• C) Institutional Review Board (IRB)
• D) Quality and Safety Education for Nurses (QSEN)
• Rationale: The primary purpose of an IRB is to review research protocols
involving human participants to guarantee ethical standards are
maintained.
Question 9
