Test Bank
Pharmacotherapeu cs for Advanced Prac ce
Nurse Prescribers 6th Edi on. Philadelphia, PA
F.A. Davis
Ques on 1
A 65-year-old pa ent with chronic kidney disease is prescribed a medica on that is primarily
eliminated by the kidneys. Which prescribing principle is most appropriate?
A. Increase the dose to overcome reduced clearance.
B. Reduce the dose or extend the dosing interval based on renal func on.
C. Avoid monitoring kidney func on a er prescribing.
D. Use the standard adult dose regardless of renal func on.
Answer: B
Ra onale: Many renally eliminated medica ons require dose adjustment when kidney
func on is reduced to avoid drug accumula on and toxicity.
Ques on 2
Which phase of pharmacokine cs describes the movement of a drug from the bloodstream
into body ssues?
A. Absorp on
B. Distribu on
C. Metabolism
D. Excre on
Answer: B
,Ra onale: Distribu on is the movement of a drug from the circula on to ssues and organs.
Ques on 3
The liver is the primary site of which pharmacokine c process?
A. Absorp on
B. Distribu on
C. Metabolism
D. Elimina on through filtra on
Answer: C
Ra onale: Hepa c enzymes, par cularly the cytochrome P450 system, metabolize many
medica ons.
Ques on 4
Which statement best describes pharmacodynamics?
A. How the body absorbs and eliminates a drug.
B. How a drug affects the body through its mechanism of ac on.
C. The cost of medica on therapy.
D. Drug storage requirements.
Answer: B
Ques on 5
An APRN reviews a pa ent's medica on list before prescribing a new drug. What is the
primary purpose of this review?
A. Reduce documenta on me.
B. Iden fy poten al drug–drug interac ons and duplicate therapies.
C. Determine insurance eligibility.
D. Replace all current medica ons.
,Answer: B
Ques on 6
Which medica on route avoids first-pass hepa c metabolism?
A. Oral
B. Sublingual
C. Enteric-coated oral tablet
D. Delayed-release capsule
Answer: B
Ra onale: Sublingual medica ons are absorbed directly into the systemic circula on.
Ques on 7
Which factor most commonly increases the risk of adverse drug events in older adults?
A. Increased liver size
B. Polypharmacy
C. Increased renal clearance
D. Higher muscle mass
Answer: B
Ques on 8
A medica on has a narrow therapeu c index. What does this indicate?
A. There is a small difference between effec ve and toxic concentra ons.
B. The medica on has no significant adverse effects.
C. The medica on rarely requires monitoring.
D. The medica on is ineffec ve.
Answer: A
, Ques on 9
Which pa ent teaching point is most important when prescribing an an bio c?
A. Stop taking the medica on once symptoms improve.
B. Complete the prescribed course unless instructed otherwise by the clinician.
C. Double the next dose if one dose is missed.
D. Share le over medica on with family members.
Answer: B
Ques on 10
Which physiologic change commonly affects medica on dosing in older adults?
A. Increased glomerular filtra on rate (GFR)
B. Decreased renal func on
C. Faster hepa c metabolism
D. Increased total body water
Answer: B
Ques on 11
Which parameter is commonly used to es mate kidney func on for medica on dosing?
A. Hemoglobin
B. Serum crea nine with es mated GFR or crea nine clearance
C. White blood cell count
D. Platelet count
Answer: B
Ques on 12
Pharmacotherapeu cs for Advanced Prac ce
Nurse Prescribers 6th Edi on. Philadelphia, PA
F.A. Davis
Ques on 1
A 65-year-old pa ent with chronic kidney disease is prescribed a medica on that is primarily
eliminated by the kidneys. Which prescribing principle is most appropriate?
A. Increase the dose to overcome reduced clearance.
B. Reduce the dose or extend the dosing interval based on renal func on.
C. Avoid monitoring kidney func on a er prescribing.
D. Use the standard adult dose regardless of renal func on.
Answer: B
Ra onale: Many renally eliminated medica ons require dose adjustment when kidney
func on is reduced to avoid drug accumula on and toxicity.
Ques on 2
Which phase of pharmacokine cs describes the movement of a drug from the bloodstream
into body ssues?
A. Absorp on
B. Distribu on
C. Metabolism
D. Excre on
Answer: B
,Ra onale: Distribu on is the movement of a drug from the circula on to ssues and organs.
Ques on 3
The liver is the primary site of which pharmacokine c process?
A. Absorp on
B. Distribu on
C. Metabolism
D. Elimina on through filtra on
Answer: C
Ra onale: Hepa c enzymes, par cularly the cytochrome P450 system, metabolize many
medica ons.
Ques on 4
Which statement best describes pharmacodynamics?
A. How the body absorbs and eliminates a drug.
B. How a drug affects the body through its mechanism of ac on.
C. The cost of medica on therapy.
D. Drug storage requirements.
Answer: B
Ques on 5
An APRN reviews a pa ent's medica on list before prescribing a new drug. What is the
primary purpose of this review?
A. Reduce documenta on me.
B. Iden fy poten al drug–drug interac ons and duplicate therapies.
C. Determine insurance eligibility.
D. Replace all current medica ons.
,Answer: B
Ques on 6
Which medica on route avoids first-pass hepa c metabolism?
A. Oral
B. Sublingual
C. Enteric-coated oral tablet
D. Delayed-release capsule
Answer: B
Ra onale: Sublingual medica ons are absorbed directly into the systemic circula on.
Ques on 7
Which factor most commonly increases the risk of adverse drug events in older adults?
A. Increased liver size
B. Polypharmacy
C. Increased renal clearance
D. Higher muscle mass
Answer: B
Ques on 8
A medica on has a narrow therapeu c index. What does this indicate?
A. There is a small difference between effec ve and toxic concentra ons.
B. The medica on has no significant adverse effects.
C. The medica on rarely requires monitoring.
D. The medica on is ineffec ve.
Answer: A
, Ques on 9
Which pa ent teaching point is most important when prescribing an an bio c?
A. Stop taking the medica on once symptoms improve.
B. Complete the prescribed course unless instructed otherwise by the clinician.
C. Double the next dose if one dose is missed.
D. Share le over medica on with family members.
Answer: B
Ques on 10
Which physiologic change commonly affects medica on dosing in older adults?
A. Increased glomerular filtra on rate (GFR)
B. Decreased renal func on
C. Faster hepa c metabolism
D. Increased total body water
Answer: B
Ques on 11
Which parameter is commonly used to es mate kidney func on for medica on dosing?
A. Hemoglobin
B. Serum crea nine with es mated GFR or crea nine clearance
C. White blood cell count
D. Platelet count
Answer: B
Ques on 12
