CBSE/STEP 1 SIMPLE MEMORIZATION QUESTIONS
WITH CORRECT ANSWERS
Na - (Cl + HCO3) - CORRECT ANSWER -Anion gap equation
What decreases the affinity of histones for DNA? - CORRECT ANSWER -Histone
acetyltransferases
What is caused by CAG as a trinucleotide repeat on Ch4? - CORRECT ANSWER -Huntingtons
What is caused by CGG trinucleotide repeat on the X chromosome? - CORRECT ANSWER -Fragile
X
What is caused by CTG trinucleotide repeats on Ch19? - CORRECT ANSWER -Myotonic
Dystrophy I
What is caused by GAA trinucleotide repeat on Ch9? - CORRECT ANSWER -Friedreich Ataxia
What is caused by one -or- both maternal gene(s) silenced on Ch15? - CORRECT ANSWER -
Prader-Willi
What mutation is responsible for homologous recombination leading to prostate, ovarian
and/or breast cancer? - CORRECT ANSWER -BRCA-1
What repair is used to correct damage done to DNA when a nucleotide is missing from the
sugar-phophate backbone or when spontaneous deamination converts a cytosine residue to a
uracil residue? - CORRECT ANSWER -Base excision repair
How is DNA-helix distorting damage repaired? - CORRECT ANSWER -Nucleotide excision repair
, What removes acetyl groups from histones which decreases the transcription of genes because
nucleosome structure becomes more compact? - CORRECT ANSWER -Histone deacetylase
UAG, UAG and UGA are known as? - CORRECT ANSWER -Stop codons
Pituitary tumors, pancreatic endocrine tumors and parathyroid adenomas are found in? -
CORRECT ANSWER -MEN1
Anti-U1 RNP (ribonucleoprotein) is found in? - CORRECT ANSWER -Mixed connective tissue
disorder
Anti-Ro/SSA and/or Anti-La/SSB are found in? - CORRECT ANSWER -Sjogren's
Anti-phospholipase A2 receptor is found in? - CORRECT ANSWER -Primary membranous
nephropathy
Anti-glutamic acid decarboxylase and/or islet cell cytoplasmic ABs are found in? - CORRECT
ANSWER -DM1
Anti-hemidesmosome is found in? - CORRECT ANSWER -Bullous pemphigoid
Antisynthetase, Anti-Jo-1, Anti-SRP, Anti-Helicase and/or Anti-Mi-2 is found in? - CORRECT
ANSWER -Polymyositis
Dermatomyositis
Anti-presynaptic voltage-gated calcium channel found in? - CORRECT ANSWER -Lambert-Eaton
WITH CORRECT ANSWERS
Na - (Cl + HCO3) - CORRECT ANSWER -Anion gap equation
What decreases the affinity of histones for DNA? - CORRECT ANSWER -Histone
acetyltransferases
What is caused by CAG as a trinucleotide repeat on Ch4? - CORRECT ANSWER -Huntingtons
What is caused by CGG trinucleotide repeat on the X chromosome? - CORRECT ANSWER -Fragile
X
What is caused by CTG trinucleotide repeats on Ch19? - CORRECT ANSWER -Myotonic
Dystrophy I
What is caused by GAA trinucleotide repeat on Ch9? - CORRECT ANSWER -Friedreich Ataxia
What is caused by one -or- both maternal gene(s) silenced on Ch15? - CORRECT ANSWER -
Prader-Willi
What mutation is responsible for homologous recombination leading to prostate, ovarian
and/or breast cancer? - CORRECT ANSWER -BRCA-1
What repair is used to correct damage done to DNA when a nucleotide is missing from the
sugar-phophate backbone or when spontaneous deamination converts a cytosine residue to a
uracil residue? - CORRECT ANSWER -Base excision repair
How is DNA-helix distorting damage repaired? - CORRECT ANSWER -Nucleotide excision repair
, What removes acetyl groups from histones which decreases the transcription of genes because
nucleosome structure becomes more compact? - CORRECT ANSWER -Histone deacetylase
UAG, UAG and UGA are known as? - CORRECT ANSWER -Stop codons
Pituitary tumors, pancreatic endocrine tumors and parathyroid adenomas are found in? -
CORRECT ANSWER -MEN1
Anti-U1 RNP (ribonucleoprotein) is found in? - CORRECT ANSWER -Mixed connective tissue
disorder
Anti-Ro/SSA and/or Anti-La/SSB are found in? - CORRECT ANSWER -Sjogren's
Anti-phospholipase A2 receptor is found in? - CORRECT ANSWER -Primary membranous
nephropathy
Anti-glutamic acid decarboxylase and/or islet cell cytoplasmic ABs are found in? - CORRECT
ANSWER -DM1
Anti-hemidesmosome is found in? - CORRECT ANSWER -Bullous pemphigoid
Antisynthetase, Anti-Jo-1, Anti-SRP, Anti-Helicase and/or Anti-Mi-2 is found in? - CORRECT
ANSWER -Polymyositis
Dermatomyositis
Anti-presynaptic voltage-gated calcium channel found in? - CORRECT ANSWER -Lambert-Eaton
