CWS (CERTIFIED WOUND SPECIALIST)
EXAM PREP 2026 | COMPLETE STUDY
GUIDE & PRACTICE QUESTIONS | GRADED
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Updated 2026 Questions and Answers
100% Verified Exam Prep and Comprehensive
Rationales Included
,What is/are the primary cell type(s) of the stratum Keratinocytes, Melanocytes, Merkel cells
basale?
What is/are the primary cell type(s) of the stratum Corneocytes (terminally differentiated keratinocytes)
granulosum?
What is/are the primary cell type(s) of the stratum Dead keratinocytes
corneum?
What is/are the primary cell type(s) of the dermis? Fibroblasts, Mast cells, Macrophages, Lymphocytes
Tissue loss includes only the epidermis. Superficial
Tissue loss includes the epidermis and part of the dermis. Partial thickness
Tissue loss includes the epidermis and all of the dermis. Full thickness
Tissue loss includes subcutaneous tissues. Subdermal
When does hemostasis or coagulation occur during the Immediately after tissue injury
stages of healing?
When does inflammation occur during the stages of 0-4 days
healing?
When does proliferation occur during the stages of 4-21 days
healing?
How long can remodeling last? Up to 2 years
What are the key cells of hemostasis? Platelets
What are the key cells of inflammation? Neutrophils, Macrophages
What are the key cells of proliferation? Fibroblasts, Epithelial cells, Endothelial cells, Macrophages
What are the key cells of remodeling? Fibroblasts
What produces PDGF? Platelets and macrophages
,What stimulates fibroblasts? Platelet Derived Growth Factor
What is an integrin? A cell surface receptor that enables cells to interact with components of the ECM
What secretes MMPs and TIMPs? Keratinocytes and fibroblasts
What regulates the activity of MMPs? TIMPs
Fibroblasts play a key role in the extracellular matrix Collagen
deposition of which types of proteins? Elastin
Reticulin
Proteoglycans
Glycosaminoglycans
Myofibroblasts secrete which type of collagen? Type I
Which type of collagen is primarily found in uninjured Type I
tissue?
Which type of collagen is primarily found in wounds in Type III
the proliferative phase of wound healing?
What is the transitional marker between the inflammatory Macrophage migration into the wound site
and proliferative phases of healing?
Which cells are the last to arrive during the proliferative T lymphocytes
phase?
What are the three types of T lymphocytes and what are 1. Cytotoxic T cells = directly target and kill any antigen-bearing cells
their functions? 2. Helper T cells = activate macrophages and B lymphocytes
3. Suppressor T cells = down regulate inflammation and proliferation as the wound
reaches maturity
, What is considered the "first line of defense" in wound Neutrophils (PMN leukocytes)
healing?
Mast cells are characterized by extensive cytoplasm with 1. Histamine
large granules which contain: 2. Heparin
3. Eicosanoids
4. Serotonin
5. Chondroitin sulfate
6. Vasoactive proteins
What type of collagen is primarily found in skin, tendon, Type I
vascular ligature, organs and bone (most common in
wounds)?
What type of collagen is primarily found in cartilage? Type II
What type of collagen is primarily found in reticulate Type III
(reticular fibers)?
What type of collagen is primarily found in basal lamina? Type IV
What type of collagen is primarily found in cell surfaces, Type V
hair and placenta?
Which enzyme stimulates fibrinolysis? Plasmin
Which type of sweat gland serves as the body cooling Eccrine sweat glands
system?
Which type of sweat gland is responsible for body odor? Apocrine sweat glands
Where are these type of glands located?
Axilla, eyelids, genitals, pubic area
Hair follicles are composed of what type of protein? Keratin
__________ hair follicles are light and fine. Vellus
__________ hair follicles are dark and thick. Terminal
What is the normal pH of skin? 4-6.5
EXAM PREP 2026 | COMPLETE STUDY
GUIDE & PRACTICE QUESTIONS | GRADED
A+ | GUARANTEED SUCCESS
Updated 2026 Questions and Answers
100% Verified Exam Prep and Comprehensive
Rationales Included
,What is/are the primary cell type(s) of the stratum Keratinocytes, Melanocytes, Merkel cells
basale?
What is/are the primary cell type(s) of the stratum Corneocytes (terminally differentiated keratinocytes)
granulosum?
What is/are the primary cell type(s) of the stratum Dead keratinocytes
corneum?
What is/are the primary cell type(s) of the dermis? Fibroblasts, Mast cells, Macrophages, Lymphocytes
Tissue loss includes only the epidermis. Superficial
Tissue loss includes the epidermis and part of the dermis. Partial thickness
Tissue loss includes the epidermis and all of the dermis. Full thickness
Tissue loss includes subcutaneous tissues. Subdermal
When does hemostasis or coagulation occur during the Immediately after tissue injury
stages of healing?
When does inflammation occur during the stages of 0-4 days
healing?
When does proliferation occur during the stages of 4-21 days
healing?
How long can remodeling last? Up to 2 years
What are the key cells of hemostasis? Platelets
What are the key cells of inflammation? Neutrophils, Macrophages
What are the key cells of proliferation? Fibroblasts, Epithelial cells, Endothelial cells, Macrophages
What are the key cells of remodeling? Fibroblasts
What produces PDGF? Platelets and macrophages
,What stimulates fibroblasts? Platelet Derived Growth Factor
What is an integrin? A cell surface receptor that enables cells to interact with components of the ECM
What secretes MMPs and TIMPs? Keratinocytes and fibroblasts
What regulates the activity of MMPs? TIMPs
Fibroblasts play a key role in the extracellular matrix Collagen
deposition of which types of proteins? Elastin
Reticulin
Proteoglycans
Glycosaminoglycans
Myofibroblasts secrete which type of collagen? Type I
Which type of collagen is primarily found in uninjured Type I
tissue?
Which type of collagen is primarily found in wounds in Type III
the proliferative phase of wound healing?
What is the transitional marker between the inflammatory Macrophage migration into the wound site
and proliferative phases of healing?
Which cells are the last to arrive during the proliferative T lymphocytes
phase?
What are the three types of T lymphocytes and what are 1. Cytotoxic T cells = directly target and kill any antigen-bearing cells
their functions? 2. Helper T cells = activate macrophages and B lymphocytes
3. Suppressor T cells = down regulate inflammation and proliferation as the wound
reaches maturity
, What is considered the "first line of defense" in wound Neutrophils (PMN leukocytes)
healing?
Mast cells are characterized by extensive cytoplasm with 1. Histamine
large granules which contain: 2. Heparin
3. Eicosanoids
4. Serotonin
5. Chondroitin sulfate
6. Vasoactive proteins
What type of collagen is primarily found in skin, tendon, Type I
vascular ligature, organs and bone (most common in
wounds)?
What type of collagen is primarily found in cartilage? Type II
What type of collagen is primarily found in reticulate Type III
(reticular fibers)?
What type of collagen is primarily found in basal lamina? Type IV
What type of collagen is primarily found in cell surfaces, Type V
hair and placenta?
Which enzyme stimulates fibrinolysis? Plasmin
Which type of sweat gland serves as the body cooling Eccrine sweat glands
system?
Which type of sweat gland is responsible for body odor? Apocrine sweat glands
Where are these type of glands located?
Axilla, eyelids, genitals, pubic area
Hair follicles are composed of what type of protein? Keratin
__________ hair follicles are light and fine. Vellus
__________ hair follicles are dark and thick. Terminal
What is the normal pH of skin? 4-6.5
