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HESI A2 Anatomy & Physiology 2026 | 350+ Exam Questions & Answers | Anatomy, Physiology, Body Systems & Nursing Entrance Exam

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Prepare thoroughly for the HESI A2 Anatomy and Physiology section with this comprehensive study guide containing 350+ exam-style questions, detailed answers, and high-yield review content covering the most frequently tested anatomy and physiology concepts on the HESI Admission Assessment Exam. This resource provides extensive practice across all major body systems, including tissues and histology, integumentary, skeletal, muscular, nervous, endocrine, cardiovascular, lymphatic, respiratory, digestive, urinary, and reproductive systems. It also reviews homeostasis, cellular structure, hormones, blood composition, muscle physiology, organ functions, and anatomical terminology commonly assessed on nursing entrance examinations. The question-and-answer format reinforces essential concepts through active recall and comprehensive explanations, helping students master difficult anatomy and physiology topics while improving retention and exam performance. Coverage includes tissue classification, epithelial and connective tissues, bone anatomy, muscle contraction, neuron function, endocrine regulation, cardiac anatomy, blood circulation, gas exchange, digestion and nutrient absorption, kidney physiology, reproductive anatomy, and hormonal regulation. These questions closely resemble the format and level of difficulty encountered on the official HESI A2 examination, making this guide an excellent resource for self-study, classroom review, and final exam preparation. Developed for students pursuing careers in nursing and allied health professions, this study material strengthens foundational anatomy and physiology knowledge while improving critical thinking and test-taking confidence. It is suitable for first-time HESI A2 candidates as well as students preparing to improve previous examination scores. References (APA 7th Edition) Elsevier. (2023). HESI Admission Assessment Exam Review (6th ed.). Elsevier. Marieb, E. N., & Hoehn, K. (2023). Human Anatomy & Physiology (12th ed.). Pearson. Tortora, G. J., & Derrickson, B. (2021). Principles of Anatomy and Physiology (16th ed.). Wiley. OpenStax. (2023). Anatomy and Physiology 2e. OpenStax, Rice University. Relevant Students HESI A2 candidates Pre-Nursing students Associate Degree in Nursing (ADN) students Bachelor of Science in Nursing (BSN) students Licensed Practical Nursing (LPN/LVN) students Registered Nursing (RN) students Allied Health students Health Sciences students Pre-Medical students Medical Assisting students Paramedic students Healthcare program applicants Keywords HESI A2 Anatomy and Physiology, HESI A2 A&P, HESI Anatomy Exam, HESI Physiology Questions, HESI A2 Practice Questions, HESI A2 Questions and Answers, Anatomy and Physiology Exam, Nursing Entrance Exam, Histology, Tissues, Integumentary System, Skeletal System, Muscular System, Nervous System, Endocrine System, Cardiovascular System, Blood, Heart Anatomy, Respiratory System, Digestive System, Urinary System, Reproductive System, Hormones, Homeostasis, Bone Anatomy, Muscle Contraction, Neurons, Human Anatomy, Human Physiology, Nursing School Admission, Allied Health, Pre-Nursing Study Guide, Anatomy Review, Physiology Review, HESI Study Guide, Healthcare Entrance Exam

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HESI A2 Anatomy and
Physiology 2026 Exam
Questions and Answers |
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What is histology? - ANSWER ✔✔The study of tissues


What is a tissue? - ANSWER ✔✔A group of cells that act together to

perform a specific function.


What are the fundamental tissues? - ANSWER ✔✔Epithelial


Connective

Muscle

,Nerve

(Elephants Can Make News)


What is the function of epithelial cells? - ANSWER ✔✔Cover, line,

and protect the body and the internal organs.


What is the function of connective tissue? - ANSWER ✔✔Framework

of the body. Provides support and structure to organs.


What is neuroglia? - ANSWER ✔✔The neurons and connective

tissue cells that compose nerve tissue.


What ability does muscle tissue have? - ANSWER ✔✔Ability to

contract and shorten.


What is muscle tissue classified as? - ANSWER

✔✔Voluntary(skeletal muscles) and involuntary(smooth & cardiac)


What is meiosis? - ANSWER ✔✔The cell division that takes place in

the gonads, i.e. the ovaries and testes.


What two layers compose the skin? - ANSWER ✔✔Epidermis and

dermis.


What is the epidermis? - ANSWER ✔✔The outermost protective layer

of dead keratinized epithelial cells.

, What is the dermis? - ANSWER ✔✔The underlying layer of

connective tissue with blood vessels, nerve endings, and the associated

skin tissues.


What are the layers of the epidermis? - ANSWER ✔✔Corneum


Lucidum

Granulosum

Germivatum ( basale & spinosum)

Mnemonic: Candy Lions Growl Great.


What does the protein pigment melanin protect against? - ANSWER

✔✔Radiation from the Sun


What is the dermis composed of? - ANSWER ✔✔Fibrous connective

tissue with nerve endings, blood vessels, sensory nerve endings, hair

follicles, and glands.


What are the 2 types of sweat glands? - ANSWER ✔✔ecrine &

apocrine


What do ecrine sweat glands produce? - ANSWER ✔✔Sweat.

Regulate body temperature.



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