NSG 533 Advanced Pharmacology Test 1 Week 4 with Answers
Graded A+
Which of the following SSRIs requires up to a 5-week
washout period because of the
long half-life of its potent active metabolite?
A. Escitalopram C
B. Fluvoxamine
C. Fluoxetine
D. Sertraline
Which of the following symptoms is most likely to improve
within approximately 1 week
of starting treatment?
A. Depressed mood D
B. Suicidal thoughts
C. Anhedonia
D. Sleep
Of the following combinations of medications, which one
would you want to avoid?
Fluoxetine-lithium
A. B
B. Fluoxetine-phenelzine
C. Citalopram-valproic acid
D. Citalopram-aripiprazole
A 26-year-old man with a history of depression has been
taking sertraline 200 mg/day for 12 weeks with no re-
sponse. The patient has no other complications. The
physician asks for your recommendation. The most rea-
sonable recommendation would be to:
D
A. Increase sertraline
B. Add fluoxetine
C. Switch to amitriptyline
D. Change to venlafaxine
E. Decrease sertraline
,NSG 533 Advanced Pharmacology Test 1 Week 4 with Answers
Graded A+
Which of the following is a dangerous combination?
A. MAOI-lorazepam
B. MAOI-acetaminophen C
C. MAOI-meperidine
D. MAOI-ziprasidone
A 23-year-old married white woman comes to the outpa-
tient psychiatric clinic
complaining of decreased sleep, decreased appetite, de-
creased concentration, depressed
mood, thoughts of death, and lack of interest in activities
for 6 weeks' duration. She has
no history of psychiatric illness and takes no medications
B
except for Ortho-Tri Cyclen Lo
daily. Based upon the patients symptoms, choose the best
medication to treat this patient.
A. Nefazodone 100 mg po twice daily
B. Paroxetine 20 mg po daily
C. St. John's wort 300 mg po three times daily
D. Amitriptyline 25 mg at bedtime
A 36-year-old man is admitted to the hospital for a severe
methicillin-resistant Staphylococcus aureus diabetic foot
infection and is started on linezolid 600 mg IV every 12
hours. His medication profile includes paroxetine 40 mg
every morning, trazodone 100 mg at bedtime as needed
for sleep, and metformin 1000 mg po twice daily. After 3 D
days on these medications, the patient becomes agitated,
confused, and diaphoretic and develops myoclonic jerks.
Which of the following is the most likely diagnosis?
A. Overdose of metformin
B. Bacterial meningitis
, NSG 533 Advanced Pharmacology Test 1 Week 4 with Answers
Graded A+
C. Neuroleptic malignant syndrome
D. Serotonin syndrome
A 46-year-old woman presents to the psychiatric outpa-
tient clinic for follow-up treatment of major depression.
She is currently on paroxetine 10 mg at bedtime, which
she started taking 2 months ago when admitted to the
psychiatric hospital for suicidal ideation. During the in-
terview, she says that she does not think the medication
is working because she is just as depressed as she was
before taking the medication and has recently started
drinking eight to 10 beers daily to alleviate the depression.
Before this episode, she was
sober for 4 years. Which of the following treatment strate- B
gies would be the appropriate choice for this patient?
A. Stop the paroxetine and start nefazodone 100 mg po
twice daily
B. Increase the dose of paroxetine to 20 mg po at bed-
time
C. Stop the paroxetine and start duloxetine 20 mg/day
D. Continue the paroxetine at them same dose for a longer
period of time to evaluate
whether she will respond or not
Which of the following is a flaw in the monoamine hypoth-
esis of depression?
A. Concentrations of neurotransmitters are reduced in the
synaptic cleft
B. D
A switch to a ditterent class of antidepressants does not
improve response
C. Antidepressant response is associated with a therapeu-
tic level of the medication
Graded A+
Which of the following SSRIs requires up to a 5-week
washout period because of the
long half-life of its potent active metabolite?
A. Escitalopram C
B. Fluvoxamine
C. Fluoxetine
D. Sertraline
Which of the following symptoms is most likely to improve
within approximately 1 week
of starting treatment?
A. Depressed mood D
B. Suicidal thoughts
C. Anhedonia
D. Sleep
Of the following combinations of medications, which one
would you want to avoid?
Fluoxetine-lithium
A. B
B. Fluoxetine-phenelzine
C. Citalopram-valproic acid
D. Citalopram-aripiprazole
A 26-year-old man with a history of depression has been
taking sertraline 200 mg/day for 12 weeks with no re-
sponse. The patient has no other complications. The
physician asks for your recommendation. The most rea-
sonable recommendation would be to:
D
A. Increase sertraline
B. Add fluoxetine
C. Switch to amitriptyline
D. Change to venlafaxine
E. Decrease sertraline
,NSG 533 Advanced Pharmacology Test 1 Week 4 with Answers
Graded A+
Which of the following is a dangerous combination?
A. MAOI-lorazepam
B. MAOI-acetaminophen C
C. MAOI-meperidine
D. MAOI-ziprasidone
A 23-year-old married white woman comes to the outpa-
tient psychiatric clinic
complaining of decreased sleep, decreased appetite, de-
creased concentration, depressed
mood, thoughts of death, and lack of interest in activities
for 6 weeks' duration. She has
no history of psychiatric illness and takes no medications
B
except for Ortho-Tri Cyclen Lo
daily. Based upon the patients symptoms, choose the best
medication to treat this patient.
A. Nefazodone 100 mg po twice daily
B. Paroxetine 20 mg po daily
C. St. John's wort 300 mg po three times daily
D. Amitriptyline 25 mg at bedtime
A 36-year-old man is admitted to the hospital for a severe
methicillin-resistant Staphylococcus aureus diabetic foot
infection and is started on linezolid 600 mg IV every 12
hours. His medication profile includes paroxetine 40 mg
every morning, trazodone 100 mg at bedtime as needed
for sleep, and metformin 1000 mg po twice daily. After 3 D
days on these medications, the patient becomes agitated,
confused, and diaphoretic and develops myoclonic jerks.
Which of the following is the most likely diagnosis?
A. Overdose of metformin
B. Bacterial meningitis
, NSG 533 Advanced Pharmacology Test 1 Week 4 with Answers
Graded A+
C. Neuroleptic malignant syndrome
D. Serotonin syndrome
A 46-year-old woman presents to the psychiatric outpa-
tient clinic for follow-up treatment of major depression.
She is currently on paroxetine 10 mg at bedtime, which
she started taking 2 months ago when admitted to the
psychiatric hospital for suicidal ideation. During the in-
terview, she says that she does not think the medication
is working because she is just as depressed as she was
before taking the medication and has recently started
drinking eight to 10 beers daily to alleviate the depression.
Before this episode, she was
sober for 4 years. Which of the following treatment strate- B
gies would be the appropriate choice for this patient?
A. Stop the paroxetine and start nefazodone 100 mg po
twice daily
B. Increase the dose of paroxetine to 20 mg po at bed-
time
C. Stop the paroxetine and start duloxetine 20 mg/day
D. Continue the paroxetine at them same dose for a longer
period of time to evaluate
whether she will respond or not
Which of the following is a flaw in the monoamine hypoth-
esis of depression?
A. Concentrations of neurotransmitters are reduced in the
synaptic cleft
B. D
A switch to a ditterent class of antidepressants does not
improve response
C. Antidepressant response is associated with a therapeu-
tic level of the medication
