STUDY GUIDE | PHYSICIAN ASSISTANT END
OF ROTATION EXAM REVIEW & PRACTICE
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,SHIVERS of Serotonin Syndrome Shivering
Hyperreflexia
Increased temp (fever)
Vitals, unstable
Encephalopathy
Restless
Sweating
Tx: Cyproheptadine
1st line Tx of depression in children Fluoxetine (Prozac)
- Longest Half-life of all SSRIs
- Caution ↑ SI in the 1st 2 weeks of use
SSRI known to cause QT interval prolongation Citalopram (Celexa)
Screening tool or questionnaire used in clinic for: BPD: The Mood Disorder Questionaire
Bipolar Disorder
Major Depression Disorder MDD: Beck Depression Inventory
Atypical Antidepressant which inhibits DA reuptake, has Bupropion
less sexual and wt-related side effects, but decreases smoking cessation
seizure threshold
SNRI Trade Names SNRI Drug Names
Effexor Venlafaxine
Pristiq Desvenlafaxine
Cymbalta Duloxetine
Fetzima Levomilnacipran
TCA antidepressants Desipramine - selective NET inhibitor
special characteristics Imipramine - tx of enuresis
Amitriptyline- tx of neuromuscular pain
Nortriptyline
QT Interval prolongation = arrythmias
MAO Inhibitors used as antidepressants Tranylcypromine
Take Pride in Shanghai Phenelzine
Selegiline
Antidepressant which inhibits MAO b mechanisms and Selegiline
can ↑ dopamine concentrations - Can be added in Tx of Parkinson's
, Suicide Risk Assessment Sex (males)
SAD PERSONS Age (biphasic)
0-4 Low Depression
5-6 Moderate Previous attempts
7-10 High Excessive substance abuse
Rational thinking, loss
Social support lacking
Organized plan
No spouse
Sick (chronic)
DIG FAST of Bipolar Distractibility
Irresponsibility
Grandiosity
Flight of ideas
Agitation
Sleep disturbances
Talkative
Bipolar II Dx:
MDD + Hypomania (DIG ST) < 1wk
Function in not fully compromised
Tx: Risperdal
Bipolar I Disorder Dx:
MDD > 2wks + Mania (DIG FAST) > 1wk
Inhibits function of daily living
Tx:
Acute Manic Episode: Antipsychotic + Mood Stabilizer
Chronic Cycle Episodes: Mood Stabilizer
Mood Stabilizers to Tx Bipolar Disorder (4) Lithium
Valproic Acid (Depakote)
Carbamazepine (Tegretol)
Lamotrigine (Lamictal)
Side Effects of Lithium Lithium Side Effects
LMNOP Movements (tremors)
Nephrotoxicity
hypOthyroid
Pregnancy problems (Ebstein's Anomoly)
Mood Stabilizer used to Tx Bipolar I Disorder w/ Lamotrigine (Lamictal)
predominant depressed state and may cause an itchy
rash or SJS