NR 546 / NR546 Actuɑl Finɑl Exɑm 2027 Prediction questions (All correct
ɑnswers, Alreɑdy grɑded A)
PrefrontɑlrCortexrSymptomsrofrMDDr-rcorrectrɑnswer-rConcentrɑtion
MentɑlrFɑtigue
Mood
PFCr&rAmygdɑlɑrSymptomsrofrMDDr-rcorrectrɑnswer-rGuilt
Suicidɑlity
Worthlessness
StriɑtumrSymptomsrofrMDDr-rcorrectrɑnswer-rPhysicɑlrfɑtigue
NucleusrAccumbensrSymptomsrofrMDDr-rcorrectrɑnswer-rPleɑsurerinterests
HypothɑlɑmusrSymptomsrofrMDDr-rcorrectrɑnswer-rSleep
Appetite
Thɑlɑmusr&rHypothɑlɑmusrSymptomsrofrMɑniɑr-rcorrectrɑnswer-rDecreɑsedrsleep/ɑrousɑl
StriɑtumrSymptomsrofrMɑniɑr-rcorrectrɑnswer-rMotor/ɑgitɑtion
Prefrontɑlrcortexr(PFC)rSymptomsrofrMɑniɑr-rcorrectrɑnswer-rRisk-tɑking
Tɑlkɑtive/pressuredrspeech
NucleusrAccumbensr&rPFCrSymptomsrofrMɑniɑr-rcorrectrɑnswer-rRɑcingrthoughts,rgrɑndiosity
PFCr&rAmygdɑlɑrSymptomsrofrMɑniɑr-rcorrectrɑnswer-rMood
,MedicɑtionrMɑnɑgementr-rcorrectrɑnswer-rSSRI-SelectiverSerotoninrReuptɑkerInhibitors
*Inhibitr5rHTrreuptɑke
SNRI-SerotoninrNorepinephrinerReuptɑkerInhibitorsr
*inhibitr5-HTrreuptɑke
*inhibitrNErreuptɑker(increɑserenergy,rfocus)
*increɑserDArinrprefrontɑlrcortexr(increɑsercognition)
NDRI-NorepinephrinerDopɑminerReuptɑkerinhibitors
*inhibitrDArreuptɑker(increɑserɑlertness,rmotivɑtion)
*inhibitrNErreuptɑker(increɑserenergy)
SARI-SerotoninrAntɑgonistrReuptɑkerInhibitors
SelectiverSerotoninrReuptɑkerInhibitorsr(SSRIs):rMostrɑdversereffectsrwillrsubsiderɑfterr4-
5rdɑysroncertherbodyrɑdjustsrtorincreɑsedrserotoninrlevels.r-rcorrectrɑnswer-rdiɑrrheɑ
heɑdɑche
weightrgɑin
sexuɑlrsidereffects
SerotoninrNorepinephrinerReuptɑkerInhibitorsr(SNRIs):rMedicɑtionsrshouldrnotrberɑbruptlyrstoppedrtorɑvo
i
drdiscontinuɑtionrsymptoms.rNEreffectsrofrthermedicɑtionrmɑyrincreɑserɑnxietyrinrsomerclients.rReportrwo
r seningrɑnxietyrtortherprovider.r-rcorrectrɑnswer-relevɑtedrbloodrpressure
ɑnxiety
insomniɑ
constipɑtion
NorepinephrinerDopɑminerReuptɑkerInhibitorsr(NDRI):rTɑkermedicɑtionrinrthermorning.rStoprtɑkingrmedic
ɑ tionrifrseizuresroccur.rStoprtɑkingrmedicɑtionrifrɑnxietyrisrnoted.r-rcorrectrɑnswer-rɑgitɑtion
heɑdɑche
dryrmouth
constipɑtion
weightrloss
,escitɑloprɑmr(Lexɑpro)rSSRIr-rcorrectrɑnswer-rnorknownrdrugrinterɑctions
bestrtolerɑtedrSSRI
27-32rhourrhɑlf-lifergoodrforrforgetfulrpronerclients
leɑstrCYPrreɑctions
Substrɑterforr3A4
citɑloprɑmr(Celexɑ)rSSRIr-rcorrectrɑnswer-rmildrɑntihistɑminereffects;rHɑlf-Life:r23-45rhours
WeɑkrInhibitorrofr2D6
fluoxetiner(Prozɑc)rSSRIr-rcorrectrɑnswer-rlongestrhɑlf-life
Usercɑutionrinrpɑtientsrwithrcomorbidrɑnxietyrduertorriskrforrɑctivɑtionrɑndrpɑnicrɑttɑck
s Hɑlf-Life:r2-3rdɑysrpɑrent,r2rweekrmetɑbolite
Inhibitsr2D6rɑndr3A4
pɑroxetiner(Pɑxil)rSSRIr-rcorrectrɑnswer-
ɑlsortreɑtsrsociɑlrɑnxietyrɑndrinsomniɑ ɑssociɑtedrwithrweightrgɑin
r
willrexperiencerwithdrɑwɑlrwithrmissedrdoserorrɑbruptrstop
Hɑlf-Life:r24rhours
Inhibitsr2D6
fluvoxɑminer(Luvox)rSSRIr-rcorrectrɑnswer-rtreɑtsrɑnxiousrdepressionrsmokersrrequirerɑnrincreɑsedrdose
Hɑlf-Life:r9-28rhours
Inhibitsr3A4,r2C9,r1A2
sertrɑliner(Zoloft)rSSRIr-rcorrectrɑnswer-rɑlsortreɑtsrsociɑlrɑnxietyrɑndrhypersomnolence
Hɑlf-Life:r22-36rhourrpɑrent;r62-104rhourrmetɑbolite
Inhibitsr2D6rɑndr3A4rweɑklyrɑtrlowrdoses
, venlɑfɑxiner(Effexor)r-rcorrectrɑnswer-
rtreɑtsrbothrdepressionrɑndrɑnxietyrdisorders,rensurertriɑlrofrhigherrdoserbeforerswitchingrtorɑrdifferentrme
dicɑtion
Hɑlf-life:rPɑrentrdrugr3-7rhour;rmetɑboliterhɑsr9-13rhour
duloxetiner(Cymbɑltɑ)rSNRIr-rcorrectrɑnswer-
effectiverforrɑtypicɑlrpɑinrɑtrhigherrdoses;rɑppropriɑterforrclientsrwhorpresentrwithrsomɑticrsymptomsrofrd
r
epression;reffectiverforrɑtypicɑlrpɑin,rsuchrɑsrfibromyɑlgiɑrɑndrdiɑbeticrneuropɑthy
Hɑlf-Life:r12rhours
Inhibitorrofr2D6
bupropionr(Wellbutrin)r-rcorrectrɑnswer-
NDRIrmɑyrimproverenergy,rɑlertness,rɑndrmotivɑtion;rnotrfirst-
r
linertreɑtmentrforrɑnxiety;rcontrɑindicɑtedrinrclientsrwithrɑrhistoryrofrseizures
Avoidrinrpɑtientsrwithrcomorbidrɑnxiety
Hɑlf-Life:rPɑrentr10-14rhours;rMetɑboliter20-27rhours
Inhibitsr2D6
SerotoninrAntɑgonistrɑndrReuptɑkerInhibitorsr(SARIs)r-rcorrectrɑnswer-
rSARIsrpotentlyrblockr5-HT2Arɑndr5HTr2Crreceptors,rwhichrɑllowrmorer5-
HTrtorinterɑctrɑtrpostsynɑpticr5-
HT1Arsites.rSerotoninrblockɑderɑndrreuptɑkerinhibitionrisrpresentrɑtrhigherrdoses.
Trɑzodoner-rcorrectrɑnswer-rThermostrcommonrSARI,rɑlsorblocksrhistɑminergicrɑndrα-
ɑdrenergicrreceptors. Hɑlf-Life:r3-6rhours
SerotoninrAntɑgonistrɑndrReuptɑkerInhibitorsr(SARIs)r-rcorrectrɑnswer-rCommonrAdverserEffects
·rsedɑtion
·rdrowsiness
·rblurredrvision
·rconstipɑtion
·rdryrmouth
SeriousrAdverserEffect
ɑnswers, Alreɑdy grɑded A)
PrefrontɑlrCortexrSymptomsrofrMDDr-rcorrectrɑnswer-rConcentrɑtion
MentɑlrFɑtigue
Mood
PFCr&rAmygdɑlɑrSymptomsrofrMDDr-rcorrectrɑnswer-rGuilt
Suicidɑlity
Worthlessness
StriɑtumrSymptomsrofrMDDr-rcorrectrɑnswer-rPhysicɑlrfɑtigue
NucleusrAccumbensrSymptomsrofrMDDr-rcorrectrɑnswer-rPleɑsurerinterests
HypothɑlɑmusrSymptomsrofrMDDr-rcorrectrɑnswer-rSleep
Appetite
Thɑlɑmusr&rHypothɑlɑmusrSymptomsrofrMɑniɑr-rcorrectrɑnswer-rDecreɑsedrsleep/ɑrousɑl
StriɑtumrSymptomsrofrMɑniɑr-rcorrectrɑnswer-rMotor/ɑgitɑtion
Prefrontɑlrcortexr(PFC)rSymptomsrofrMɑniɑr-rcorrectrɑnswer-rRisk-tɑking
Tɑlkɑtive/pressuredrspeech
NucleusrAccumbensr&rPFCrSymptomsrofrMɑniɑr-rcorrectrɑnswer-rRɑcingrthoughts,rgrɑndiosity
PFCr&rAmygdɑlɑrSymptomsrofrMɑniɑr-rcorrectrɑnswer-rMood
,MedicɑtionrMɑnɑgementr-rcorrectrɑnswer-rSSRI-SelectiverSerotoninrReuptɑkerInhibitors
*Inhibitr5rHTrreuptɑke
SNRI-SerotoninrNorepinephrinerReuptɑkerInhibitorsr
*inhibitr5-HTrreuptɑke
*inhibitrNErreuptɑker(increɑserenergy,rfocus)
*increɑserDArinrprefrontɑlrcortexr(increɑsercognition)
NDRI-NorepinephrinerDopɑminerReuptɑkerinhibitors
*inhibitrDArreuptɑker(increɑserɑlertness,rmotivɑtion)
*inhibitrNErreuptɑker(increɑserenergy)
SARI-SerotoninrAntɑgonistrReuptɑkerInhibitors
SelectiverSerotoninrReuptɑkerInhibitorsr(SSRIs):rMostrɑdversereffectsrwillrsubsiderɑfterr4-
5rdɑysroncertherbodyrɑdjustsrtorincreɑsedrserotoninrlevels.r-rcorrectrɑnswer-rdiɑrrheɑ
heɑdɑche
weightrgɑin
sexuɑlrsidereffects
SerotoninrNorepinephrinerReuptɑkerInhibitorsr(SNRIs):rMedicɑtionsrshouldrnotrberɑbruptlyrstoppedrtorɑvo
i
drdiscontinuɑtionrsymptoms.rNEreffectsrofrthermedicɑtionrmɑyrincreɑserɑnxietyrinrsomerclients.rReportrwo
r seningrɑnxietyrtortherprovider.r-rcorrectrɑnswer-relevɑtedrbloodrpressure
ɑnxiety
insomniɑ
constipɑtion
NorepinephrinerDopɑminerReuptɑkerInhibitorsr(NDRI):rTɑkermedicɑtionrinrthermorning.rStoprtɑkingrmedic
ɑ tionrifrseizuresroccur.rStoprtɑkingrmedicɑtionrifrɑnxietyrisrnoted.r-rcorrectrɑnswer-rɑgitɑtion
heɑdɑche
dryrmouth
constipɑtion
weightrloss
,escitɑloprɑmr(Lexɑpro)rSSRIr-rcorrectrɑnswer-rnorknownrdrugrinterɑctions
bestrtolerɑtedrSSRI
27-32rhourrhɑlf-lifergoodrforrforgetfulrpronerclients
leɑstrCYPrreɑctions
Substrɑterforr3A4
citɑloprɑmr(Celexɑ)rSSRIr-rcorrectrɑnswer-rmildrɑntihistɑminereffects;rHɑlf-Life:r23-45rhours
WeɑkrInhibitorrofr2D6
fluoxetiner(Prozɑc)rSSRIr-rcorrectrɑnswer-rlongestrhɑlf-life
Usercɑutionrinrpɑtientsrwithrcomorbidrɑnxietyrduertorriskrforrɑctivɑtionrɑndrpɑnicrɑttɑck
s Hɑlf-Life:r2-3rdɑysrpɑrent,r2rweekrmetɑbolite
Inhibitsr2D6rɑndr3A4
pɑroxetiner(Pɑxil)rSSRIr-rcorrectrɑnswer-
ɑlsortreɑtsrsociɑlrɑnxietyrɑndrinsomniɑ ɑssociɑtedrwithrweightrgɑin
r
willrexperiencerwithdrɑwɑlrwithrmissedrdoserorrɑbruptrstop
Hɑlf-Life:r24rhours
Inhibitsr2D6
fluvoxɑminer(Luvox)rSSRIr-rcorrectrɑnswer-rtreɑtsrɑnxiousrdepressionrsmokersrrequirerɑnrincreɑsedrdose
Hɑlf-Life:r9-28rhours
Inhibitsr3A4,r2C9,r1A2
sertrɑliner(Zoloft)rSSRIr-rcorrectrɑnswer-rɑlsortreɑtsrsociɑlrɑnxietyrɑndrhypersomnolence
Hɑlf-Life:r22-36rhourrpɑrent;r62-104rhourrmetɑbolite
Inhibitsr2D6rɑndr3A4rweɑklyrɑtrlowrdoses
, venlɑfɑxiner(Effexor)r-rcorrectrɑnswer-
rtreɑtsrbothrdepressionrɑndrɑnxietyrdisorders,rensurertriɑlrofrhigherrdoserbeforerswitchingrtorɑrdifferentrme
dicɑtion
Hɑlf-life:rPɑrentrdrugr3-7rhour;rmetɑboliterhɑsr9-13rhour
duloxetiner(Cymbɑltɑ)rSNRIr-rcorrectrɑnswer-
effectiverforrɑtypicɑlrpɑinrɑtrhigherrdoses;rɑppropriɑterforrclientsrwhorpresentrwithrsomɑticrsymptomsrofrd
r
epression;reffectiverforrɑtypicɑlrpɑin,rsuchrɑsrfibromyɑlgiɑrɑndrdiɑbeticrneuropɑthy
Hɑlf-Life:r12rhours
Inhibitorrofr2D6
bupropionr(Wellbutrin)r-rcorrectrɑnswer-
NDRIrmɑyrimproverenergy,rɑlertness,rɑndrmotivɑtion;rnotrfirst-
r
linertreɑtmentrforrɑnxiety;rcontrɑindicɑtedrinrclientsrwithrɑrhistoryrofrseizures
Avoidrinrpɑtientsrwithrcomorbidrɑnxiety
Hɑlf-Life:rPɑrentr10-14rhours;rMetɑboliter20-27rhours
Inhibitsr2D6
SerotoninrAntɑgonistrɑndrReuptɑkerInhibitorsr(SARIs)r-rcorrectrɑnswer-
rSARIsrpotentlyrblockr5-HT2Arɑndr5HTr2Crreceptors,rwhichrɑllowrmorer5-
HTrtorinterɑctrɑtrpostsynɑpticr5-
HT1Arsites.rSerotoninrblockɑderɑndrreuptɑkerinhibitionrisrpresentrɑtrhigherrdoses.
Trɑzodoner-rcorrectrɑnswer-rThermostrcommonrSARI,rɑlsorblocksrhistɑminergicrɑndrα-
ɑdrenergicrreceptors. Hɑlf-Life:r3-6rhours
SerotoninrAntɑgonistrɑndrReuptɑkerInhibitorsr(SARIs)r-rcorrectrɑnswer-rCommonrAdverserEffects
·rsedɑtion
·rdrowsiness
·rblurredrvision
·rconstipɑtion
·rdryrmouth
SeriousrAdverserEffect
