APEA 3P High Stakes Exam 2026
Questions and Answers Graded A+ 2026
/2027
APEA 3P High Stakes Exam - Correct answer-Exam coverage
The exam coverage includes advanced clinical knowledge assessed in the APEA 3P
High Stakes Exam provided by Advanced Practice Education Associates (APEA).
It focuses on the three core graduate nursing competencies known as the "3Ps":
advanced pathophysiology, pharmacology, and physical assessment. The exam
evaluates understanding of disease mechanisms, diagnostic reasoning, patient
assessment techniques, and appropriate pharmacologic and non-pharmacologic
treatment options. Emphasis is placed on clinical decision-making, interpretation
of patient findings, and the application of evidence-based practice in the
management of common acute and chronic conditions across the lifespan
Taking Pyridium for UTI, what can Pyridium cause? - Correct answer-Hemolytic
Anemia
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,What can PCOS result in? - Correct answer-Increased insulin levels
(Hyperinsulinemia), Androgens, Hirsutism
What would cause decrease in Digoxin levels? - Correct answer-Antacids
What are the anti-hypertensives used in pregnancy? - Correct answer-Methyldopa
(Alpha-2-Agonist), Labetalol, Nifedipine, Hydralazine
What is a characteristic of Placenta Previa? - Correct answer-Painless, red bleeding
What is a chacteristic of Rheumatoid Arthritis? - Correct answer-Tender, warm,
swollen joints
Medications that can cause ototoxicity? - Correct answer-Aminoglycosides, loop
diuretics, NSAIDs, antihistamines, nasal decongestants
What is the treatment time for enterobiasis? - Correct answer-2 weeks
What does MCV lab value measure? - Correct answer-Mean Corpuscular Volume
helps diagnose different types of anemia such as B12 & Folate (Macrocytic) and
Fe anemia (Microcytic)
Rhogam is given at how many week gestation? - Correct answer-27-28 weeks
What are Janeway lesions and what do they indicate? - Correct answer-They are
irregular, non-tender hemorrhagic macules located on the hands and feet. Seen in
Infective Endocarditis
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,What are Osler's Nodes and what do they indicate? - Correct answer-They are split
pea-sized, erythematous, tender nodules located on the pads of the fingers and toes.
Seen in Infective Endocarditis
What is the recommendation for Warfarin management when a patient misses a
dose? - Correct answer-If within 12 hours of the dose time, take it. If over 12 hours
patient will need a INR redraw
What do we need to know about ACEs and ARBs? - Correct answer-A dry hacking
cough is a common side effect of ACEs and will go away within a week after
discontinuing. ACEs & ARBs are indicated for patients with DM, CKD, and HTN.
Not recommended as 1st line agent with African Americans & can cause
angioedema.
Contraindications for Hydrochlorothiazide - Correct answer-Sulfa allergy, PCN
hypersensitivity, Asthma, Gout
Systolic Murmurs (Benign) - Correct answer-MR = Mitral Regurge (SOB/Fatigue
HF)
Peyton Manning = Physiologic Murmur (Asymptomatic)
AS = Aortic Stenosis (Angina, Syncope HF)
MVP = Mitral Valve Prolapse ("Click", Women 14-30, Palpitations, Chest Pain
©COPYRIGHT 2025,ALL RIGHTS RESERVED 3
, Diastolic Murmurs (Abnormal) - Correct answer-AR = Aortic Regurgitation
(Angina, HF, Dizziness, Chest Pain)
MS = Mitral Stenosis (Dyspnea, AFib)
What does S1 indicate? - Correct answer-S1 Closure of the Atrioventricular Valves
(Mitral & Tricuspid Valves)
What does S2 indicate? - Correct answer-S2 Closure of the Semilunar Valves
(Aortic & Pulmonic Valves)
S3 is often heard in? - Correct answer-CHF, possibly normal for athletic
adolescents
S4 is often heard in? - Correct answer-Diastolic HF, Left Ventricular Hypertrophy
(LVH), Poorly controlled HTN, MI
Treatment of Peripheral Artery Disease (PAD) - Correct answer-Antiplatelets
(Plavix, ASA), Pentoxifylline (Decreases blood viscosity)
Diagnosing Peripheral Artery Disease (PAD) - Correct answer-Gold Standard =
Angiography
Ankle Brachial Index (ABI)
©COPYRIGHT 2025,ALL RIGHTS RESERVED 4
Questions and Answers Graded A+ 2026
/2027
APEA 3P High Stakes Exam - Correct answer-Exam coverage
The exam coverage includes advanced clinical knowledge assessed in the APEA 3P
High Stakes Exam provided by Advanced Practice Education Associates (APEA).
It focuses on the three core graduate nursing competencies known as the "3Ps":
advanced pathophysiology, pharmacology, and physical assessment. The exam
evaluates understanding of disease mechanisms, diagnostic reasoning, patient
assessment techniques, and appropriate pharmacologic and non-pharmacologic
treatment options. Emphasis is placed on clinical decision-making, interpretation
of patient findings, and the application of evidence-based practice in the
management of common acute and chronic conditions across the lifespan
Taking Pyridium for UTI, what can Pyridium cause? - Correct answer-Hemolytic
Anemia
©COPYRIGHT 2025,ALL RIGHTS RESERVED 1
,What can PCOS result in? - Correct answer-Increased insulin levels
(Hyperinsulinemia), Androgens, Hirsutism
What would cause decrease in Digoxin levels? - Correct answer-Antacids
What are the anti-hypertensives used in pregnancy? - Correct answer-Methyldopa
(Alpha-2-Agonist), Labetalol, Nifedipine, Hydralazine
What is a characteristic of Placenta Previa? - Correct answer-Painless, red bleeding
What is a chacteristic of Rheumatoid Arthritis? - Correct answer-Tender, warm,
swollen joints
Medications that can cause ototoxicity? - Correct answer-Aminoglycosides, loop
diuretics, NSAIDs, antihistamines, nasal decongestants
What is the treatment time for enterobiasis? - Correct answer-2 weeks
What does MCV lab value measure? - Correct answer-Mean Corpuscular Volume
helps diagnose different types of anemia such as B12 & Folate (Macrocytic) and
Fe anemia (Microcytic)
Rhogam is given at how many week gestation? - Correct answer-27-28 weeks
What are Janeway lesions and what do they indicate? - Correct answer-They are
irregular, non-tender hemorrhagic macules located on the hands and feet. Seen in
Infective Endocarditis
©COPYRIGHT 2025,ALL RIGHTS RESERVED 2
,What are Osler's Nodes and what do they indicate? - Correct answer-They are split
pea-sized, erythematous, tender nodules located on the pads of the fingers and toes.
Seen in Infective Endocarditis
What is the recommendation for Warfarin management when a patient misses a
dose? - Correct answer-If within 12 hours of the dose time, take it. If over 12 hours
patient will need a INR redraw
What do we need to know about ACEs and ARBs? - Correct answer-A dry hacking
cough is a common side effect of ACEs and will go away within a week after
discontinuing. ACEs & ARBs are indicated for patients with DM, CKD, and HTN.
Not recommended as 1st line agent with African Americans & can cause
angioedema.
Contraindications for Hydrochlorothiazide - Correct answer-Sulfa allergy, PCN
hypersensitivity, Asthma, Gout
Systolic Murmurs (Benign) - Correct answer-MR = Mitral Regurge (SOB/Fatigue
HF)
Peyton Manning = Physiologic Murmur (Asymptomatic)
AS = Aortic Stenosis (Angina, Syncope HF)
MVP = Mitral Valve Prolapse ("Click", Women 14-30, Palpitations, Chest Pain
©COPYRIGHT 2025,ALL RIGHTS RESERVED 3
, Diastolic Murmurs (Abnormal) - Correct answer-AR = Aortic Regurgitation
(Angina, HF, Dizziness, Chest Pain)
MS = Mitral Stenosis (Dyspnea, AFib)
What does S1 indicate? - Correct answer-S1 Closure of the Atrioventricular Valves
(Mitral & Tricuspid Valves)
What does S2 indicate? - Correct answer-S2 Closure of the Semilunar Valves
(Aortic & Pulmonic Valves)
S3 is often heard in? - Correct answer-CHF, possibly normal for athletic
adolescents
S4 is often heard in? - Correct answer-Diastolic HF, Left Ventricular Hypertrophy
(LVH), Poorly controlled HTN, MI
Treatment of Peripheral Artery Disease (PAD) - Correct answer-Antiplatelets
(Plavix, ASA), Pentoxifylline (Decreases blood viscosity)
Diagnosing Peripheral Artery Disease (PAD) - Correct answer-Gold Standard =
Angiography
Ankle Brachial Index (ABI)
©COPYRIGHT 2025,ALL RIGHTS RESERVED 4
