LEHNE PHARM ADRENERGIC ANTAGONISTS NEWEST
PRACTICE EXAM 100+ QUESTIONS AND ANSWERS
WITH VERIFIED CORRECT ANSWERS |A+ GRADED
1. Which statement best describes the primary action of adrenergic
antagonists?
A. Stimulate adrenergic receptors
B. Increase norepinephrine release
C. Block the effects of sympathetic neurotransmitters
D. Enhance catecholamine synthesis
Rationale: Adrenergic antagonists inhibit the effects of norepinephrine and
epinephrine at adrenergic receptors.
2. Which receptor is primarily blocked by prazosin?
A. α2
B. α1
C. β1
D. β2
Rationale: Prazosin is a selective α1-adrenergic receptor antagonist.
3. Which drug is most commonly used for benign prostatic hyperplasia (BPH)?
A. Propranolol
B. Phenoxybenzamine
C. Tamsulosin
D. Timolol
Rationale: Tamsulosin selectively blocks α1A receptors in the prostate and bladder
neck.
4. A major adverse effect of α1 blockers is:
,A. Hyperglycemia
B. Bradycardia
C. Bronchospasm
D. Orthostatic hypotension
Rationale: Vasodilation produced by α1 blockade can cause a significant fall in
blood pressure upon standing.
5. Which drug irreversibly blocks α receptors?
A. Phentolamine
B. Prazosin
C. Terazosin
D. Phenoxybenzamine
Rationale: Phenoxybenzamine forms irreversible covalent bonds with α receptors.
6. Which drug is a reversible nonselective α blocker?
A. Phenoxybenzamine
B. Phentolamine
C. Doxazosin
D. Tamsulosin
Rationale: Phentolamine competitively blocks both α1 and α2 receptors.
7. Phenoxybenzamine is most commonly used in the management of:
A. Asthma
B. Heart failure
C. Pheochromocytoma
D. Glaucoma
Rationale: Phenoxybenzamine is used before surgical removal of
pheochromocytoma to control hypertension.
8. Which receptor blockade causes relaxation of smooth muscle in the bladder
neck?
, A. β1
B. β2
C. α2
D. α1
Rationale: α1 receptor blockade decreases urinary resistance and improves urine
flow.
9. The “first-dose phenomenon” is associated with:
A. Propranolol
B. Atenolol
C. Prazosin
D. Esmolol
Rationale: Marked orthostatic hypotension may occur after the first dose of
prazosin.
10.Which drug selectively blocks β1 receptors?
A. Propranolol
B. Nadolol
C. Timolol
D. Metoprolol
Rationale: Metoprolol is a cardioselective β1 antagonist.
11.Which beta blocker is nonselective?
A. Atenolol
B. Metoprolol
C. Bisoprolol
D. Propranolol
Rationale: Propranolol blocks both β1 and β2 receptors.
12.Blocking β1 receptors causes:
A. Bronchodilation
B. Increased heart rate
PRACTICE EXAM 100+ QUESTIONS AND ANSWERS
WITH VERIFIED CORRECT ANSWERS |A+ GRADED
1. Which statement best describes the primary action of adrenergic
antagonists?
A. Stimulate adrenergic receptors
B. Increase norepinephrine release
C. Block the effects of sympathetic neurotransmitters
D. Enhance catecholamine synthesis
Rationale: Adrenergic antagonists inhibit the effects of norepinephrine and
epinephrine at adrenergic receptors.
2. Which receptor is primarily blocked by prazosin?
A. α2
B. α1
C. β1
D. β2
Rationale: Prazosin is a selective α1-adrenergic receptor antagonist.
3. Which drug is most commonly used for benign prostatic hyperplasia (BPH)?
A. Propranolol
B. Phenoxybenzamine
C. Tamsulosin
D. Timolol
Rationale: Tamsulosin selectively blocks α1A receptors in the prostate and bladder
neck.
4. A major adverse effect of α1 blockers is:
,A. Hyperglycemia
B. Bradycardia
C. Bronchospasm
D. Orthostatic hypotension
Rationale: Vasodilation produced by α1 blockade can cause a significant fall in
blood pressure upon standing.
5. Which drug irreversibly blocks α receptors?
A. Phentolamine
B. Prazosin
C. Terazosin
D. Phenoxybenzamine
Rationale: Phenoxybenzamine forms irreversible covalent bonds with α receptors.
6. Which drug is a reversible nonselective α blocker?
A. Phenoxybenzamine
B. Phentolamine
C. Doxazosin
D. Tamsulosin
Rationale: Phentolamine competitively blocks both α1 and α2 receptors.
7. Phenoxybenzamine is most commonly used in the management of:
A. Asthma
B. Heart failure
C. Pheochromocytoma
D. Glaucoma
Rationale: Phenoxybenzamine is used before surgical removal of
pheochromocytoma to control hypertension.
8. Which receptor blockade causes relaxation of smooth muscle in the bladder
neck?
, A. β1
B. β2
C. α2
D. α1
Rationale: α1 receptor blockade decreases urinary resistance and improves urine
flow.
9. The “first-dose phenomenon” is associated with:
A. Propranolol
B. Atenolol
C. Prazosin
D. Esmolol
Rationale: Marked orthostatic hypotension may occur after the first dose of
prazosin.
10.Which drug selectively blocks β1 receptors?
A. Propranolol
B. Nadolol
C. Timolol
D. Metoprolol
Rationale: Metoprolol is a cardioselective β1 antagonist.
11.Which beta blocker is nonselective?
A. Atenolol
B. Metoprolol
C. Bisoprolol
D. Propranolol
Rationale: Propranolol blocks both β1 and β2 receptors.
12.Blocking β1 receptors causes:
A. Bronchodilation
B. Increased heart rate
