Bio 420 Exam 3 Questions With Correct
Answers
T cell receptor (TCR) forms molecular interactions with: -
| | | | | | | | |
ANSWER✔✔✔-peptide anitgen and self MHC | | | |
Which statement about BCR is false?
| | | | |
a
BCR recognizes and binds to native extracellular antigens
| | | | | | |
b
BCR can be endocytosed after binding to antigen
| | | | | | |
c
BCR is used to present a processed antigen to a helper T (TH) cell
| | | | | | | | | | | | |
d
Antigen binding to BCR generates an intracellular signal -
| | | | | | | | |
ANSWER✔✔✔-BCR is used to present a processed antigen to a helper T
| | | | | | | | | | | |
(TH) cell
|
BCR and TCR have all of the following in common EXCEPT: -
| | | | | | | | | | | |
ANSWER✔✔✔-receptor has multiple antigen binding sites | | | | |
,Rearrange the following gene segments of the BCR heavy chain gene
| | | | | | | | | | |
into the correct final order in the mRNA transcript. - ANSWER✔✔✔-V
| | | | | | | | | |
D
J
C
Which BCR chain is most similar to the TCR beta chain in terms of
| | | | | | | | | | | | | |
genetic organization of the variable region? - ANSWER✔✔✔-heavy
| | | | | | | |
chain
Which factor is involved in creating junctional diversity during both TCR
| | | | | | | | | | |
and BCR gene rearrangements? - ANSWER✔✔✔-TdT
| | | | |
Although they are produced in the bone marrow from hematopoietic
| | | | | | | | | |
stem cells, T cells migrate to the <CHOOSE ANSWER> where they
| | | | | | | | | | |
develop and mature. - ANSWER✔✔✔-thymus
| | | |
Immature T cells that express functional TCR are called <CHOOSE
| | | | | | | | | |
ANSWER> because they express both CD4 and CD8 co-receptors. -
| | | | | | | | | |
ANSWER✔✔✔-double-positive
What happens to a double-positive thymocyte whose TCR binds with
| | | | | | | | | |
low affinity to a peptide presented with MHC I by a cortical thymic
| | | | | | | | | | | | |
, epithelial cell (cTEC)? - ANSWER✔✔✔-it becomes an immature single-
| | | | | | | |
positive CD8 thymocyte | |
What happens to a single-positive CD4 thymocyte whose TCR does not
| | | | | | | | | | |
bind to a peptide presented with MHC by a thymic dendritic cell (DC)? -
| | | | | | | | | | | | | |
ANSWER✔✔✔-it becomes a mature naive CD4 T lymphocyte | | | | | | |
Arrange the following steps for T cell development in the correct order. -
| | | | | | | | | | | |
ANSWER✔✔✔-b. double-negative thymocytes enter thymic cortex
| | | | | |
a. functional TCR and both CD4 and CD8 co-receptors are expressed in
| | | | | | | | | | | |
double-positive thymocyte |
c. MHC restriction in thymic cortex produces single-positive CD4 or CD8
| | | | | | | | | | |
thymocytes
d. self tolerance is created in thymic medulla by deleting autoreactive
| | | | | | | | | | |
single-positive thymocytes |
e. mature naive CD4 or CD8 T lymphocytes leave thymic medulla
| | | | | | | | | |
What event causes positive selection, i.e. survival, of immature B
| | | | | | | | | |
lymphocytes during their development? - ANSWER✔✔✔-Immature B
| | | | | | |
cell expresses BCR with functional heavy and light chains
| | | | | | | |
An important checkpoint during B cell development is the formation of
| | | | | | | | | | |
the pre-BCR, which is comprised of the mu heavy chain and: -
| | | | | | | | | | | |
ANSWER✔✔✔-surrogate light chain | |
Answers
T cell receptor (TCR) forms molecular interactions with: -
| | | | | | | | |
ANSWER✔✔✔-peptide anitgen and self MHC | | | |
Which statement about BCR is false?
| | | | |
a
BCR recognizes and binds to native extracellular antigens
| | | | | | |
b
BCR can be endocytosed after binding to antigen
| | | | | | |
c
BCR is used to present a processed antigen to a helper T (TH) cell
| | | | | | | | | | | | |
d
Antigen binding to BCR generates an intracellular signal -
| | | | | | | | |
ANSWER✔✔✔-BCR is used to present a processed antigen to a helper T
| | | | | | | | | | | |
(TH) cell
|
BCR and TCR have all of the following in common EXCEPT: -
| | | | | | | | | | | |
ANSWER✔✔✔-receptor has multiple antigen binding sites | | | | |
,Rearrange the following gene segments of the BCR heavy chain gene
| | | | | | | | | | |
into the correct final order in the mRNA transcript. - ANSWER✔✔✔-V
| | | | | | | | | |
D
J
C
Which BCR chain is most similar to the TCR beta chain in terms of
| | | | | | | | | | | | | |
genetic organization of the variable region? - ANSWER✔✔✔-heavy
| | | | | | | |
chain
Which factor is involved in creating junctional diversity during both TCR
| | | | | | | | | | |
and BCR gene rearrangements? - ANSWER✔✔✔-TdT
| | | | |
Although they are produced in the bone marrow from hematopoietic
| | | | | | | | | |
stem cells, T cells migrate to the <CHOOSE ANSWER> where they
| | | | | | | | | | |
develop and mature. - ANSWER✔✔✔-thymus
| | | |
Immature T cells that express functional TCR are called <CHOOSE
| | | | | | | | | |
ANSWER> because they express both CD4 and CD8 co-receptors. -
| | | | | | | | | |
ANSWER✔✔✔-double-positive
What happens to a double-positive thymocyte whose TCR binds with
| | | | | | | | | |
low affinity to a peptide presented with MHC I by a cortical thymic
| | | | | | | | | | | | |
, epithelial cell (cTEC)? - ANSWER✔✔✔-it becomes an immature single-
| | | | | | | |
positive CD8 thymocyte | |
What happens to a single-positive CD4 thymocyte whose TCR does not
| | | | | | | | | | |
bind to a peptide presented with MHC by a thymic dendritic cell (DC)? -
| | | | | | | | | | | | | |
ANSWER✔✔✔-it becomes a mature naive CD4 T lymphocyte | | | | | | |
Arrange the following steps for T cell development in the correct order. -
| | | | | | | | | | | |
ANSWER✔✔✔-b. double-negative thymocytes enter thymic cortex
| | | | | |
a. functional TCR and both CD4 and CD8 co-receptors are expressed in
| | | | | | | | | | | |
double-positive thymocyte |
c. MHC restriction in thymic cortex produces single-positive CD4 or CD8
| | | | | | | | | | |
thymocytes
d. self tolerance is created in thymic medulla by deleting autoreactive
| | | | | | | | | | |
single-positive thymocytes |
e. mature naive CD4 or CD8 T lymphocytes leave thymic medulla
| | | | | | | | | |
What event causes positive selection, i.e. survival, of immature B
| | | | | | | | | |
lymphocytes during their development? - ANSWER✔✔✔-Immature B
| | | | | | |
cell expresses BCR with functional heavy and light chains
| | | | | | | |
An important checkpoint during B cell development is the formation of
| | | | | | | | | | |
the pre-BCR, which is comprised of the mu heavy chain and: -
| | | | | | | | | | | |
ANSWER✔✔✔-surrogate light chain | |
