Exam 2 NURS 5334 Advanced Pharmacology Practice Test
with 200 Questions and Correct Detailed Answers/ NURS
5334 Exam 2 Latest Practice Test 2026-2027 (UTA)
A 36-year-old woman requests birth control. She has no medical conditions, and
she smokes one pack of cigarettes per day. Which of the following would be the
most appropriate to recommend?
Progestin-only mini-pill
Vaginal contraceptive ring
Combination oral contraceptive pill
Transdermal contraceptive patch
Progestin-only mini-pill
Progestin-only products are preferred in older women who are smokers, due to a
lower risk of severe adverse effects, such as myocardial infarction and stroke.
Estrogen-containing contraceptives are not recommended in women over the age
of 35 years who are smokers. The vaginal contraceptive ring, transdermal
contraceptive patch, and combination oral contraceptive pills all contain estrogen.
Which of the following hormonal agents is paired with the most likely adverse
effect?
Levonorgestrel-hot flashes
Testosterone-increased libido
Drospirenone-hypokalemia
Ethinyl estradiol-hypotension
Testosterone-increased libido
The androgenic effects of testosterone may enhance libido. Drospirenone is an
analog of spironolactone and may increase retention of potassium, leading to
hyperkalemia. Estrogen in oral contraceptives may increase blood pressure (not
reduce blood pressure). The progestin levonorgestrel may have androgenic effects
1
,(for example, acne and hirsutism). Hot flashes are usually attributed to a lack of
estrogen or antagonism of estrogen receptors.
A 45-year-old woman needs a renal transplant due to sequela related to chronic
hypertension and diabetes. Which of the following agents is most appropriate to
include in the induction regimen for this patient?
Azathioprine
Cyclosporine
Bortezomib
Basiliximab
Basiliximab is a monoclonal antibody used in induction. Cyclosporine and
azathioprine are indicated for maintenance therapy, and bortezomib can be used for
antibody-mediated organ rejection.
A 39-year-old man is admitted 3 months after liver transplant with increased liver
function tests. A liver biopsy is performed and the results show acute rejection,
severe. The team decides to start treatment with antithymocyte globulin. What
additional drug therapy is required for appropriate administration of this
medication?
Diphenhydramine, ketorolac, corticosteroids.
No additional medications are required.
Diphenhydramine, acetaminophen.
Diphenhydramine, acetaminophen, corticosteroids.
Diphenhydramine, acetaminophen, corticosteroids.
Infusion-related reactions are common with the administration of antithymocyte
globulins due to cytokine release. Common symptoms include chills, fever,
hypotension, and pulmonary edema. Premedication with acetaminophen,
diphenhydramine, and corticosteroids should be administered 30 minutes prior to
the start of the infusion to prevent this syndrome. Although diphenhydramine and
acetaminophen are correct, corticosteroids are also needed as premedication.
2
,Ketorolac is not the most appropriate for use as premedication for antithymocyte
globulin.
Which of the following immunosuppressant drugs binds to CD52 receptors,
resulting in T- and B-cell depletion?
Rituximab
Belimumab
Alemtuzumab
Belatacept
Alemtuzumab
As a humanized monoclonal antibody, alemtuzumab selectively binds CD52,
which is highly expressed on lymphocytes and causes the depletion of both T and
B cells from circulation. Rituximab binds the CD20 and can result in B-cell
depletion. Belatacept is a selective T-cell costimulatory blocker, while belimumab
is a B lymphocyte-specific inhibitor.
A 21-year-old woman is admitted to receive a kidney transplant from her father.
Since she has a low-to-moderate risk of rejection, she will receive basiliximab.
Which statement best describes the uniqueness of basiliximab compared to other
antibody agents?
Poorly tolerated induction monotherapy.
Does not require pre-medication prior to administration.
Administered only in combination with antithymocyte globulin.
Mechanism of action targets B cells with no effect on T-cells.
Does not require pre-medication prior to administration.
Basiliximab does not require pre-medication prior to administration since it is a
nondepleting agent and would not be expected to cause cytokine release or
infusion reactions. It can be used in combination with antithymocyte globulin, but
most commonly it is used alone. Basiliximab primarily affects T-cells at the CD25
receptor.
A 29-year-old woman presents to her physician with complaints of heartburn,
weight gain, and mood changes after starting a new medication for transplant
3
, maintenance. A laboratory evaluation also reveals that her blood glucose is
elevated. Which of the following medications most likely caused these adverse
effects?
Tofacitinib
Prednisone
Cyclosporine
Sirolimus
Prednisone
Common adverse effects of corticosteroids (prednisone) can include upset
stomach, weight gain, acne, insomnia, hyperglycemia, and mood changes. Patients
should be encouraged to take corticosteroids with food and in the morning
whenever possible to minimize both stomach distress and trouble sleeping.
An 18-year-old woman who received a kidney transplant 6 months prior presents
to the transplant clinic complaining of facial hair growth. Her current maintenance
regimen includes cyclosporine, mycophenolate mofetil, and prednisone. Which
treatment option would be the most appropriate recommendation to address her
concerns?
Switch mycophenolate mofetil to mycophenolic acid.
Stop prednisone and add tofacitinib.
Stop mycophenolate mofetil.
Switch cyclosporine to tacrolimus.
Switch cyclosporine to tacrolimus. Hirsutism, or excessive hair growth, is a well-
known adverse effect of cyclosporine. Many patients experience dark, coarse facial
or body hair growth while taking cyclosporine. Switching cyclosporine to
tacrolimus would eliminate this adverse effect and keep the patient on a calcineurin
inhibitor that is effective in preventing rejection. Mycophenolate, tacrolimus, and
prednisone are not known to cause hirsutism.
Which of the following combinations of immunosuppressive drugs should be
avoided?
Azathioprine, prednisone, and sirolimus
4
with 200 Questions and Correct Detailed Answers/ NURS
5334 Exam 2 Latest Practice Test 2026-2027 (UTA)
A 36-year-old woman requests birth control. She has no medical conditions, and
she smokes one pack of cigarettes per day. Which of the following would be the
most appropriate to recommend?
Progestin-only mini-pill
Vaginal contraceptive ring
Combination oral contraceptive pill
Transdermal contraceptive patch
Progestin-only mini-pill
Progestin-only products are preferred in older women who are smokers, due to a
lower risk of severe adverse effects, such as myocardial infarction and stroke.
Estrogen-containing contraceptives are not recommended in women over the age
of 35 years who are smokers. The vaginal contraceptive ring, transdermal
contraceptive patch, and combination oral contraceptive pills all contain estrogen.
Which of the following hormonal agents is paired with the most likely adverse
effect?
Levonorgestrel-hot flashes
Testosterone-increased libido
Drospirenone-hypokalemia
Ethinyl estradiol-hypotension
Testosterone-increased libido
The androgenic effects of testosterone may enhance libido. Drospirenone is an
analog of spironolactone and may increase retention of potassium, leading to
hyperkalemia. Estrogen in oral contraceptives may increase blood pressure (not
reduce blood pressure). The progestin levonorgestrel may have androgenic effects
1
,(for example, acne and hirsutism). Hot flashes are usually attributed to a lack of
estrogen or antagonism of estrogen receptors.
A 45-year-old woman needs a renal transplant due to sequela related to chronic
hypertension and diabetes. Which of the following agents is most appropriate to
include in the induction regimen for this patient?
Azathioprine
Cyclosporine
Bortezomib
Basiliximab
Basiliximab is a monoclonal antibody used in induction. Cyclosporine and
azathioprine are indicated for maintenance therapy, and bortezomib can be used for
antibody-mediated organ rejection.
A 39-year-old man is admitted 3 months after liver transplant with increased liver
function tests. A liver biopsy is performed and the results show acute rejection,
severe. The team decides to start treatment with antithymocyte globulin. What
additional drug therapy is required for appropriate administration of this
medication?
Diphenhydramine, ketorolac, corticosteroids.
No additional medications are required.
Diphenhydramine, acetaminophen.
Diphenhydramine, acetaminophen, corticosteroids.
Diphenhydramine, acetaminophen, corticosteroids.
Infusion-related reactions are common with the administration of antithymocyte
globulins due to cytokine release. Common symptoms include chills, fever,
hypotension, and pulmonary edema. Premedication with acetaminophen,
diphenhydramine, and corticosteroids should be administered 30 minutes prior to
the start of the infusion to prevent this syndrome. Although diphenhydramine and
acetaminophen are correct, corticosteroids are also needed as premedication.
2
,Ketorolac is not the most appropriate for use as premedication for antithymocyte
globulin.
Which of the following immunosuppressant drugs binds to CD52 receptors,
resulting in T- and B-cell depletion?
Rituximab
Belimumab
Alemtuzumab
Belatacept
Alemtuzumab
As a humanized monoclonal antibody, alemtuzumab selectively binds CD52,
which is highly expressed on lymphocytes and causes the depletion of both T and
B cells from circulation. Rituximab binds the CD20 and can result in B-cell
depletion. Belatacept is a selective T-cell costimulatory blocker, while belimumab
is a B lymphocyte-specific inhibitor.
A 21-year-old woman is admitted to receive a kidney transplant from her father.
Since she has a low-to-moderate risk of rejection, she will receive basiliximab.
Which statement best describes the uniqueness of basiliximab compared to other
antibody agents?
Poorly tolerated induction monotherapy.
Does not require pre-medication prior to administration.
Administered only in combination with antithymocyte globulin.
Mechanism of action targets B cells with no effect on T-cells.
Does not require pre-medication prior to administration.
Basiliximab does not require pre-medication prior to administration since it is a
nondepleting agent and would not be expected to cause cytokine release or
infusion reactions. It can be used in combination with antithymocyte globulin, but
most commonly it is used alone. Basiliximab primarily affects T-cells at the CD25
receptor.
A 29-year-old woman presents to her physician with complaints of heartburn,
weight gain, and mood changes after starting a new medication for transplant
3
, maintenance. A laboratory evaluation also reveals that her blood glucose is
elevated. Which of the following medications most likely caused these adverse
effects?
Tofacitinib
Prednisone
Cyclosporine
Sirolimus
Prednisone
Common adverse effects of corticosteroids (prednisone) can include upset
stomach, weight gain, acne, insomnia, hyperglycemia, and mood changes. Patients
should be encouraged to take corticosteroids with food and in the morning
whenever possible to minimize both stomach distress and trouble sleeping.
An 18-year-old woman who received a kidney transplant 6 months prior presents
to the transplant clinic complaining of facial hair growth. Her current maintenance
regimen includes cyclosporine, mycophenolate mofetil, and prednisone. Which
treatment option would be the most appropriate recommendation to address her
concerns?
Switch mycophenolate mofetil to mycophenolic acid.
Stop prednisone and add tofacitinib.
Stop mycophenolate mofetil.
Switch cyclosporine to tacrolimus.
Switch cyclosporine to tacrolimus. Hirsutism, or excessive hair growth, is a well-
known adverse effect of cyclosporine. Many patients experience dark, coarse facial
or body hair growth while taking cyclosporine. Switching cyclosporine to
tacrolimus would eliminate this adverse effect and keep the patient on a calcineurin
inhibitor that is effective in preventing rejection. Mycophenolate, tacrolimus, and
prednisone are not known to cause hirsutism.
Which of the following combinations of immunosuppressive drugs should be
avoided?
Azathioprine, prednisone, and sirolimus
4
