COMSAE Exam Study Guide –
Practice Questions with Verified
Answers. GRADED A+. Latest
2026/2027 Update
COCAINE intoxication - Answer✔✔- impaired judgement,
pupil dilate, hallucination (coke bugs) sudden cardiac death; paranoid ideations, angina
Tx: alpha blockers/ benzos
caution B block bc can cause unopposed alpha
Osteoporosis histo - Answer✔✔- trabecular and cortical bone
lose mass and interconnection despite normal bone mineralization
assoc w/ Colles fracture- distal radial fracture; fracture of femoral neck
Gilbert Syndrome - Answer✔✔- mild dec UDP glucuronosyltransferase conjugation and
impaired bilirubin uptake; asymptomatic or mild jaundice>> inc unconjugated bilirubin
w/o hemolysis; w/ fasting and stress
Crigler Najjar - Answer✔✔- ABSENT UDP
glucuronsyltransferase; early in life; die few years
find: jaundice, kernicterus (in brain) inc unconjugated bilirubin;
tx: plasmapheresis and phototherapy; type II respond phenobarbital
Dubin Johnson - Answer✔✔- Conjugated hyperbilirubinemia
b/c defective liver excretion;
grossly black liver
Benign
,Rotor syndrome - Answer✔✔- milder in presentation w/o black
liver
impaired hepatic uptake and excretion
wilson Disease - Answer✔✔- copper transporting ATPase;
ATP7B on Chromosome 13
s/s: before 40 yo, liver dz, neurodisease, psych dz, Kayser Fleischer ring, hemolytic
anemia, renal dz;
find: dec serum ceruloplasmin, inc urine copper
tx: chelation w/ penicillamine or Tridentine, oral zinc
Hemochromatosis - Answer✔✔- recessive, HFE, chromosome
6; abnormal iron sensing, increase intestinal absorb
find: inc ferritin, inc iron, dec TIBC, inc transferrin saturation
identify w/ Prussian blue stain/ liver MRI
Hemochromatosis finds - Answer✔✔- after age 40
>20 iron;
triad: cirrhosis, DM, skin pigmentation; dilated cardiomyopathy, hypogonadism,
arhtropathy; HCC is common cause death
Treatment Hemochromatosis - Answer✔✔- repeat
phlebotomy, chelation deferasirox, deferoxamine, oral deferiprone
Wolff Parkinson White Syndrome - Answer✔✔- MC ventricular
pre excitation syndrome
abnml fast atria to ventricle (bundle of Kent); bypasses AV node>> ventricles begin
partially depolarization earlier (NOTED BY DELTA WAVE ON EKG) widened QRS and
shortened PR
Conduction pathway heart - Answer✔✔- SA node> atira> AV
node> bundle HIS, R and L bundle branches> purkinje fibers> ventricles
L branch anterior/posterior fascicles
Edema - Answer✔✔- inc capillary pressure
dec plasma proteins (dec oncotic capillary pressure)
inc capillary permeability
, increase interstitial fluid colloid oncotic pressure
Celiac Disease - Answer✔✔- setting: 14 mo kid losing weight
eating lots of foods;
histology: crypt abnormalities (hyperplasia); villous atrophy, lymphocytic infiltration
presents as malabsorbtion (diarrhea etc in kids) in
adults= short stature, anemia delayed puberty
Musculocutaneous nerve C5-C7 - Answer✔✔-
upper trunk compression cause injury; loss
forearm flexion/supination; loss sensation over
lateral forearm
Axillary nerve C5-C6 - Answer✔✔- flat deltoid; loss arm
abduction, loss sensation over deltoid and lateral arm
Radial C5-T1 - Answer✔✔- mid shaft fracture humerus,
compression axilla
find: dec grip, loss extension (wrist drop); loss sensation posterior arm, dorsal hand
Median C5-T1 - Answer✔✔- supracondylar fracture humerus
(proximal) CTS, wrist laceration (distal)
ape hand pope's blessing
loss wrist flexion, flex of lateral fingers, thumb opposition, lumbricals 2nd and 3rd digit;
loss sensation over thenar eminence and dorsal and palmar aspects of lateral 3 1/2
fingers w/ proximal
Ulnar C8-T1 - Answer✔✔- Fracture medial epicondyle
humerus; fractured hook hamate (distal lesion)
ulnar claw on extension; radial deception wrist upon flexion (proximal lesion)
loss wrist flex, flex of medial fingers, abduction and adduction fingers; medial 2
lumbricals;
loss sensation over 1 1/2 fingers including hypothenar eminence
Recurrent branch median nerve - Answer✔✔- superficial
laceration palm
Practice Questions with Verified
Answers. GRADED A+. Latest
2026/2027 Update
COCAINE intoxication - Answer✔✔- impaired judgement,
pupil dilate, hallucination (coke bugs) sudden cardiac death; paranoid ideations, angina
Tx: alpha blockers/ benzos
caution B block bc can cause unopposed alpha
Osteoporosis histo - Answer✔✔- trabecular and cortical bone
lose mass and interconnection despite normal bone mineralization
assoc w/ Colles fracture- distal radial fracture; fracture of femoral neck
Gilbert Syndrome - Answer✔✔- mild dec UDP glucuronosyltransferase conjugation and
impaired bilirubin uptake; asymptomatic or mild jaundice>> inc unconjugated bilirubin
w/o hemolysis; w/ fasting and stress
Crigler Najjar - Answer✔✔- ABSENT UDP
glucuronsyltransferase; early in life; die few years
find: jaundice, kernicterus (in brain) inc unconjugated bilirubin;
tx: plasmapheresis and phototherapy; type II respond phenobarbital
Dubin Johnson - Answer✔✔- Conjugated hyperbilirubinemia
b/c defective liver excretion;
grossly black liver
Benign
,Rotor syndrome - Answer✔✔- milder in presentation w/o black
liver
impaired hepatic uptake and excretion
wilson Disease - Answer✔✔- copper transporting ATPase;
ATP7B on Chromosome 13
s/s: before 40 yo, liver dz, neurodisease, psych dz, Kayser Fleischer ring, hemolytic
anemia, renal dz;
find: dec serum ceruloplasmin, inc urine copper
tx: chelation w/ penicillamine or Tridentine, oral zinc
Hemochromatosis - Answer✔✔- recessive, HFE, chromosome
6; abnormal iron sensing, increase intestinal absorb
find: inc ferritin, inc iron, dec TIBC, inc transferrin saturation
identify w/ Prussian blue stain/ liver MRI
Hemochromatosis finds - Answer✔✔- after age 40
>20 iron;
triad: cirrhosis, DM, skin pigmentation; dilated cardiomyopathy, hypogonadism,
arhtropathy; HCC is common cause death
Treatment Hemochromatosis - Answer✔✔- repeat
phlebotomy, chelation deferasirox, deferoxamine, oral deferiprone
Wolff Parkinson White Syndrome - Answer✔✔- MC ventricular
pre excitation syndrome
abnml fast atria to ventricle (bundle of Kent); bypasses AV node>> ventricles begin
partially depolarization earlier (NOTED BY DELTA WAVE ON EKG) widened QRS and
shortened PR
Conduction pathway heart - Answer✔✔- SA node> atira> AV
node> bundle HIS, R and L bundle branches> purkinje fibers> ventricles
L branch anterior/posterior fascicles
Edema - Answer✔✔- inc capillary pressure
dec plasma proteins (dec oncotic capillary pressure)
inc capillary permeability
, increase interstitial fluid colloid oncotic pressure
Celiac Disease - Answer✔✔- setting: 14 mo kid losing weight
eating lots of foods;
histology: crypt abnormalities (hyperplasia); villous atrophy, lymphocytic infiltration
presents as malabsorbtion (diarrhea etc in kids) in
adults= short stature, anemia delayed puberty
Musculocutaneous nerve C5-C7 - Answer✔✔-
upper trunk compression cause injury; loss
forearm flexion/supination; loss sensation over
lateral forearm
Axillary nerve C5-C6 - Answer✔✔- flat deltoid; loss arm
abduction, loss sensation over deltoid and lateral arm
Radial C5-T1 - Answer✔✔- mid shaft fracture humerus,
compression axilla
find: dec grip, loss extension (wrist drop); loss sensation posterior arm, dorsal hand
Median C5-T1 - Answer✔✔- supracondylar fracture humerus
(proximal) CTS, wrist laceration (distal)
ape hand pope's blessing
loss wrist flexion, flex of lateral fingers, thumb opposition, lumbricals 2nd and 3rd digit;
loss sensation over thenar eminence and dorsal and palmar aspects of lateral 3 1/2
fingers w/ proximal
Ulnar C8-T1 - Answer✔✔- Fracture medial epicondyle
humerus; fractured hook hamate (distal lesion)
ulnar claw on extension; radial deception wrist upon flexion (proximal lesion)
loss wrist flex, flex of medial fingers, abduction and adduction fingers; medial 2
lumbricals;
loss sensation over 1 1/2 fingers including hypothenar eminence
Recurrent branch median nerve - Answer✔✔- superficial
laceration palm
