MARYVILLE NURS 663 ALL STUDY EXAMS GUIDE
QUESTIONS AND ANSWERS SURE A+
✔✔What is rapid cycling bipolar disorder? - ✔✔-four or more distinct mood episodes
within a 12 month period
-can occur in any order
-up to 20% of all bipolar pts
-risk factors: longer length of illness, female, ANTIDEPRESSANT USE, thyroid disease,
older age
✔✔what birth defects might be seen with valproic acid? - ✔✔cleft palate
✔✔what medications are safe in postpartum depression? - ✔✔
✔✔why is lithium XR a good option for some patients? - ✔✔it might help decrease
stomach upset
✔✔Paroxetine (Paxil) - ✔✔SSRI antidepressant
-short half life (good in case mania pops up)
- can be sedating, so consider dosing at night to help sleep
SE: most anticholinergic SSRI, ↑↑sexual dysfunction
, Inhibits antipsychotics
***SIGNIFICANT 2D6 inhibition
can cause discontinuation syndrome (nausea, vertigo)
✔✔Sertraline (Zoloft) - ✔✔SSRI
antidepressant
treats major depressive disorder, panic disorder, OCD, PTSD, social phobia, PMDD
contraindicated with MAOI
Adverse reactions: neuroleptic malignant syndrome, suicidal thoughts, seratonin
syndrome
common side effects: dizziness, drowsiness, fatigue, headache, insomnia diarrhea, dry
mouth, nausea, sexual dysfunction,sweating, tremors
Pros:
** short half-life
** less sedating than paroxetine
** very weak CYP 450 interactions (very slight 2d6)
Cons:
** requires full stomach for max absorption
** lots of GI affects
✔✔Fluoxetine (Prozac) - ✔✔Antidepressant, SSRI's
- long half life (must have 5 weeks between this and MAOI)
can be activating, which can help with energy
can use when tapering off other SSRI to help minimize discontinuation syndrome
not a good option for hepatic patients (d/t long half life)
*** a lot of cyp 450 interactions, so not a good option with other meds
watch for mania since activating
✔✔Escitalopram (Lexapro) - ✔✔Antidepressant, SSRI: 10-20 mg qd
can cause QT prolongation (especially in doses >20mg)
QUESTIONS AND ANSWERS SURE A+
✔✔What is rapid cycling bipolar disorder? - ✔✔-four or more distinct mood episodes
within a 12 month period
-can occur in any order
-up to 20% of all bipolar pts
-risk factors: longer length of illness, female, ANTIDEPRESSANT USE, thyroid disease,
older age
✔✔what birth defects might be seen with valproic acid? - ✔✔cleft palate
✔✔what medications are safe in postpartum depression? - ✔✔
✔✔why is lithium XR a good option for some patients? - ✔✔it might help decrease
stomach upset
✔✔Paroxetine (Paxil) - ✔✔SSRI antidepressant
-short half life (good in case mania pops up)
- can be sedating, so consider dosing at night to help sleep
SE: most anticholinergic SSRI, ↑↑sexual dysfunction
, Inhibits antipsychotics
***SIGNIFICANT 2D6 inhibition
can cause discontinuation syndrome (nausea, vertigo)
✔✔Sertraline (Zoloft) - ✔✔SSRI
antidepressant
treats major depressive disorder, panic disorder, OCD, PTSD, social phobia, PMDD
contraindicated with MAOI
Adverse reactions: neuroleptic malignant syndrome, suicidal thoughts, seratonin
syndrome
common side effects: dizziness, drowsiness, fatigue, headache, insomnia diarrhea, dry
mouth, nausea, sexual dysfunction,sweating, tremors
Pros:
** short half-life
** less sedating than paroxetine
** very weak CYP 450 interactions (very slight 2d6)
Cons:
** requires full stomach for max absorption
** lots of GI affects
✔✔Fluoxetine (Prozac) - ✔✔Antidepressant, SSRI's
- long half life (must have 5 weeks between this and MAOI)
can be activating, which can help with energy
can use when tapering off other SSRI to help minimize discontinuation syndrome
not a good option for hepatic patients (d/t long half life)
*** a lot of cyp 450 interactions, so not a good option with other meds
watch for mania since activating
✔✔Escitalopram (Lexapro) - ✔✔Antidepressant, SSRI: 10-20 mg qd
can cause QT prolongation (especially in doses >20mg)
