22. As a person ages, the water content of the cartilage decreases as a result of a
reduced proteoglycan content, thus causing the cartilage to be less resilient (i.e.,
durable).
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A-->Primary Osteoarthritis
10. How does the composition of articular cartilage change with age (i.e., number of
chrondrocytes or composition of ECM)?
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, The number of chondrocytes does not decrease, *but the combination of
decrease hydration and size and structure of proteoglycan aggregates
negatively affects the viscoelastic properties and biomechanical
behavior of articular cartilage
Decrease hydration of matrix with a corresponding increase in compressive
stiffness
the size and structure of proteoglycan aggregates within the ECM
decreases with age, which is thought to occur as the result of proteolytic
damage to link proteins and their glycosaminoglycan chains
11. What are osteophytes and where do they form?
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Osteophytes are bony outgrowths (spurs) that arise in the periosteum
overlying the bone at the junction between cartilage and bone due to
damage of the articular cartilage
1. What specific area of the joint is affected by the "wear and tear" of aging?
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Articular cartilage.
Lubrication injections
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, *Injections of hyaluronic acid derivatives
(Hyalgan, Synvisc) may offer pain relief by providing some cushioning
within the knee
joint.*
These treatments are *made of rooster combs and
are similar to a component normally found in the joint fluid. *
*Usually consist of a series of injections spaced
about one week apart.*
9. What are the two main components of articular cartilage? What are the three main
components of extracellular matrix (ECM)?
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TWO MAIN COMPONENTS OF ART. CARTILAGE
Chrondrocytes and extracellular matrix (ECM)
THREE MAIN COMPONENTS OF ECM
Water, collagen, and proteoglycans.
Exercise Programs
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goals of an exercise program are to maintain range of motion, muscle
strength, and general health.
evidence shows that patients with osteoarthritic joints who participated in
regular lowimpact
exercise (e.g., biking and elliptical machines) did not have an increased
development of osteoarthritis.
reduced proteoglycan content, thus causing the cartilage to be less resilient (i.e.,
durable).
Give this one a try later!
A-->Primary Osteoarthritis
10. How does the composition of articular cartilage change with age (i.e., number of
chrondrocytes or composition of ECM)?
Give this one a try later!
, The number of chondrocytes does not decrease, *but the combination of
decrease hydration and size and structure of proteoglycan aggregates
negatively affects the viscoelastic properties and biomechanical
behavior of articular cartilage
Decrease hydration of matrix with a corresponding increase in compressive
stiffness
the size and structure of proteoglycan aggregates within the ECM
decreases with age, which is thought to occur as the result of proteolytic
damage to link proteins and their glycosaminoglycan chains
11. What are osteophytes and where do they form?
Give this one a try later!
Osteophytes are bony outgrowths (spurs) that arise in the periosteum
overlying the bone at the junction between cartilage and bone due to
damage of the articular cartilage
1. What specific area of the joint is affected by the "wear and tear" of aging?
Give this one a try later!
Articular cartilage.
Lubrication injections
Give this one a try later!
, *Injections of hyaluronic acid derivatives
(Hyalgan, Synvisc) may offer pain relief by providing some cushioning
within the knee
joint.*
These treatments are *made of rooster combs and
are similar to a component normally found in the joint fluid. *
*Usually consist of a series of injections spaced
about one week apart.*
9. What are the two main components of articular cartilage? What are the three main
components of extracellular matrix (ECM)?
Give this one a try later!
TWO MAIN COMPONENTS OF ART. CARTILAGE
Chrondrocytes and extracellular matrix (ECM)
THREE MAIN COMPONENTS OF ECM
Water, collagen, and proteoglycans.
Exercise Programs
Give this one a try later!
goals of an exercise program are to maintain range of motion, muscle
strength, and general health.
evidence shows that patients with osteoarthritic joints who participated in
regular lowimpact
exercise (e.g., biking and elliptical machines) did not have an increased
development of osteoarthritis.
