2026/2027
NR 565 Advanced Pharmacology
Final Exam 2026/2027 Complete
Practice Questions, Quiz Collection,
and Detailed Study Guide for
Chamberlain College
Question 1
Phenothiazines such as chlorpromazine are primarily used in the management of
which condition?
A. Anxiety disorders
B. Psychosis
C. Hypertension
D. Epilepsy
Correct Answer: B. Psychosis
Rationale: Phenothiazines are first-generation antipsychotic medications used to
manage psychotic disorders such as schizophrenia. They work by blocking dopamine
receptors in the brain, reducing hallucinations, delusions, and disorganized thinking.
They are not first-line treatments for anxiety, hypertension, or epilepsy, although they
may have sedative effects that can be misleading.
Question 2
An adverse effect commonly associated with α1-adrenergic blockers is:
A. Hypertension
B. Hypotension
C. Hyperglycemia
D. Bradycardia
Correct Answer: B. Hypotension
Rationale: α1-blockers such as tamsulosin cause vasodilation by blocking sympathetic
tone in blood vessels, often leading to orthostatic hypotension, especially after the
first dose. They are not associated with hypertension or significant effects on blood
glucose. Bradycardia is more commonly linked to beta-blockers.
,2026/2027
Question 3
Which drug acts centrally on the hypothalamus to reduce fever?
A. Ibuprofen
B. Acetaminophen
C. Aspirin
D. Morphine
Correct Answer: B. Acetaminophen
Rationale: Acetaminophen reduces fever by acting on the hypothalamic heat-
regulating center, lowering prostaglandin synthesis. Ibuprofen and aspirin act more
peripherally as NSAIDs, while morphine is an opioid analgesic with no antipyretic
effect.
Question 4
Which drug classes are commonly used to manage benign prostatic hyperplasia
(BPH)?
A. Beta-2 agonists and diuretics
B. Alpha-1 blockers and 5-alpha reductase inhibitors
C. ACE inhibitors and ARBs
D. Calcium channel blockers only
Correct Answer: B. Alpha-1 blockers and 5-alpha reductase inhibitors
Rationale: Alpha-1 blockers relax smooth muscle in the prostate and bladder neck,
improving urine flow, while 5-alpha reductase inhibitors reduce prostate size by
decreasing dihydrotestosterone. Other options do not address prostate enlargement.
Question 5
Benzodiazepines and antihistamines are commonly used to reduce:
A. Pain
B. Anxiety
C. Fever
D. Infection
Correct Answer: B. Anxiety
Rationale: Both benzodiazepines and some antihistamines have sedative effects on the
central nervous system, reducing anxiety and promoting relaxation. They are not
primary treatments for pain, fever, or infection.
,2026/2027
Question 6
A cholinergic crisis is most likely to present with:
A. Hypertension and tachycardia
B. Bronchodilation and dry skin
C. Bronchoconstriction and hypotension
D. Hyperactivity and insomnia
Correct Answer: C. Bronchoconstriction and hypotension
Rationale: Excess acetylcholine activity causes parasympathetic overactivation
leading to bronchoconstriction, hypotension, bradycardia, and increased secretions. It
is the opposite of sympathetic stimulation.
Question 7
Clients with asthma or COPD should avoid which medication class?
A. Non-selective beta-blockers
B. ACE inhibitors
C. Diuretics
D. Antacids
Correct Answer: A. Non-selective beta-blockers
Rationale: Non-selective beta-blockers block β2 receptors in the lungs, leading to
bronchoconstriction, which can worsen asthma and COPD symptoms. ACE inhibitors
may cause cough but do not directly constrict airways.
Question 8
Hydroxyzine and diphenhydramine are classified as:
A. Antidepressants
B. Antihistamines used for anxiety
C. Beta-blockers
D. Antipsychotics
Correct Answer: B. Antihistamines used for anxiety
Rationale: These first-generation antihistamines have sedative properties and are
sometimes used to treat anxiety and insomnia. They are not antidepressants, beta-
blockers, or antipsychotics.
, 2026/2027
Question 9
Which of the following are catecholamines?
A. Dopamine, serotonin, acetylcholine
B. Epinephrine, norepinephrine, dopamine
C. Histamine, dopamine, insulin
D. Acetylcholine, norepinephrine, GABA
Correct Answer: B. Epinephrine, norepinephrine, dopamine
Rationale: Catecholamines are sympathetic neurotransmitters involved in the fight-or-
flight response. Epinephrine, norepinephrine, and dopamine are the primary
catecholamines used clinically and physiologically.
Question 10
Beta-1 adrenergic receptors are primarily located in the:
A. Lungs
B. Heart
C. Kidneys
D. Liver
Correct Answer: B. Heart
Rationale: Beta-1 receptors are predominantly found in cardiac tissue, where they
increase heart rate and contractility. Beta-2 receptors are primarily in the lungs.
Question 11
Cholinergic drugs mimic which physiological response?
A. Sympathetic (fight or flight)
B. Parasympathetic (rest and digest)
C. Endocrine response
D. Immune response
Correct Answer: B. Parasympathetic (rest and digest)
Rationale: Cholinergic drugs stimulate the parasympathetic nervous system,
promoting rest-and-digest functions such as decreased heart rate and increased GI
activity.
NR 565 Advanced Pharmacology
Final Exam 2026/2027 Complete
Practice Questions, Quiz Collection,
and Detailed Study Guide for
Chamberlain College
Question 1
Phenothiazines such as chlorpromazine are primarily used in the management of
which condition?
A. Anxiety disorders
B. Psychosis
C. Hypertension
D. Epilepsy
Correct Answer: B. Psychosis
Rationale: Phenothiazines are first-generation antipsychotic medications used to
manage psychotic disorders such as schizophrenia. They work by blocking dopamine
receptors in the brain, reducing hallucinations, delusions, and disorganized thinking.
They are not first-line treatments for anxiety, hypertension, or epilepsy, although they
may have sedative effects that can be misleading.
Question 2
An adverse effect commonly associated with α1-adrenergic blockers is:
A. Hypertension
B. Hypotension
C. Hyperglycemia
D. Bradycardia
Correct Answer: B. Hypotension
Rationale: α1-blockers such as tamsulosin cause vasodilation by blocking sympathetic
tone in blood vessels, often leading to orthostatic hypotension, especially after the
first dose. They are not associated with hypertension or significant effects on blood
glucose. Bradycardia is more commonly linked to beta-blockers.
,2026/2027
Question 3
Which drug acts centrally on the hypothalamus to reduce fever?
A. Ibuprofen
B. Acetaminophen
C. Aspirin
D. Morphine
Correct Answer: B. Acetaminophen
Rationale: Acetaminophen reduces fever by acting on the hypothalamic heat-
regulating center, lowering prostaglandin synthesis. Ibuprofen and aspirin act more
peripherally as NSAIDs, while morphine is an opioid analgesic with no antipyretic
effect.
Question 4
Which drug classes are commonly used to manage benign prostatic hyperplasia
(BPH)?
A. Beta-2 agonists and diuretics
B. Alpha-1 blockers and 5-alpha reductase inhibitors
C. ACE inhibitors and ARBs
D. Calcium channel blockers only
Correct Answer: B. Alpha-1 blockers and 5-alpha reductase inhibitors
Rationale: Alpha-1 blockers relax smooth muscle in the prostate and bladder neck,
improving urine flow, while 5-alpha reductase inhibitors reduce prostate size by
decreasing dihydrotestosterone. Other options do not address prostate enlargement.
Question 5
Benzodiazepines and antihistamines are commonly used to reduce:
A. Pain
B. Anxiety
C. Fever
D. Infection
Correct Answer: B. Anxiety
Rationale: Both benzodiazepines and some antihistamines have sedative effects on the
central nervous system, reducing anxiety and promoting relaxation. They are not
primary treatments for pain, fever, or infection.
,2026/2027
Question 6
A cholinergic crisis is most likely to present with:
A. Hypertension and tachycardia
B. Bronchodilation and dry skin
C. Bronchoconstriction and hypotension
D. Hyperactivity and insomnia
Correct Answer: C. Bronchoconstriction and hypotension
Rationale: Excess acetylcholine activity causes parasympathetic overactivation
leading to bronchoconstriction, hypotension, bradycardia, and increased secretions. It
is the opposite of sympathetic stimulation.
Question 7
Clients with asthma or COPD should avoid which medication class?
A. Non-selective beta-blockers
B. ACE inhibitors
C. Diuretics
D. Antacids
Correct Answer: A. Non-selective beta-blockers
Rationale: Non-selective beta-blockers block β2 receptors in the lungs, leading to
bronchoconstriction, which can worsen asthma and COPD symptoms. ACE inhibitors
may cause cough but do not directly constrict airways.
Question 8
Hydroxyzine and diphenhydramine are classified as:
A. Antidepressants
B. Antihistamines used for anxiety
C. Beta-blockers
D. Antipsychotics
Correct Answer: B. Antihistamines used for anxiety
Rationale: These first-generation antihistamines have sedative properties and are
sometimes used to treat anxiety and insomnia. They are not antidepressants, beta-
blockers, or antipsychotics.
, 2026/2027
Question 9
Which of the following are catecholamines?
A. Dopamine, serotonin, acetylcholine
B. Epinephrine, norepinephrine, dopamine
C. Histamine, dopamine, insulin
D. Acetylcholine, norepinephrine, GABA
Correct Answer: B. Epinephrine, norepinephrine, dopamine
Rationale: Catecholamines are sympathetic neurotransmitters involved in the fight-or-
flight response. Epinephrine, norepinephrine, and dopamine are the primary
catecholamines used clinically and physiologically.
Question 10
Beta-1 adrenergic receptors are primarily located in the:
A. Lungs
B. Heart
C. Kidneys
D. Liver
Correct Answer: B. Heart
Rationale: Beta-1 receptors are predominantly found in cardiac tissue, where they
increase heart rate and contractility. Beta-2 receptors are primarily in the lungs.
Question 11
Cholinergic drugs mimic which physiological response?
A. Sympathetic (fight or flight)
B. Parasympathetic (rest and digest)
C. Endocrine response
D. Immune response
Correct Answer: B. Parasympathetic (rest and digest)
Rationale: Cholinergic drugs stimulate the parasympathetic nervous system,
promoting rest-and-digest functions such as decreased heart rate and increased GI
activity.
