NURS 5334 ANTIMICROBIALS ACTUAL
EXAM SCRIPT 2026 FULL QUESTIONS AND
CORRECT ANSWERS
◉ COC (combined oral contraceptives).
Answer: increased cervical cancer risk
decreased endometrial/ovarian cancer risk
contraindicated in CVA
thromboembolic
contraindicated with estrogen dependent cancers, liver disease,
pregnancy, >35 smokers
◉ Androgens.
Answer: steroids with anabolic effects
testosterone- ineffective orally
fluoxymesterone- hypogonadism- oral
oxandrolone- chronic wasting d/t HIV or cancer-oral
donazol- endometriosis and fibrocystic breast disease
◉ Antiandrogens.
Answer: counteract male hormonal action.
,Finasteride/ dutasteride- inhibit 5-alpha reductast, used to treat
BPH.
flutamaide, bicalutamide, enzalutamide, nilutamide- treat prostate
cancer.
◉ Alternative to HRT.
Answer: SSRI (paroxetine), SNRI, clonidine, gabapentin
◉ PUD (peptic ulcer disease).
Answer: Main causes: gram (-) H. pylori & NSAIDS
drugs used: amoxicillin, bismuth, clarithromycin, metronidazole,
tetracycline. >90% treated with quad therapy (pesto, flagyl,
tetracycline, PPI) X 1wk
◉ H2 blockers MOA.
Answer: reduce secretion of acid. competitive antagonist of
histamine that are fully reveersible. Can cross placenta. Renal dose
adjustment needed.
◉ Cimetidine (Tagamet).
Answer: H2 blocker.
inhibits CYP450 and will interfere with metabolism of warfarin,
phenytoin, plavix.
,◉ H2 blockers.
Answer: Cimetidine
Famotidine
Nizatidine
Ranitidine
◉ PPI MOA.
Answer: suppress secretion of H+ ions by binding to H+/K+ ATPase
enzymes.
Used as 1st line treatment for GERD with severe heartburn.
acid-resistant coating, breaks down in alkaline duodenum, absorbed
in parietal cells.
Take 30-60 minutes before breakfast.
◉ PPI drugs (-prazole).
Answer: Lansoprazole (Prevacid)
dexlansoprazole
omeprazole (Prilosec)
esmeprazole (Nexium)
pantoprazole
rabeprazole
, ◉ Prilosec and Nexium.
Answer: decrease effectiveness of plavix by inhibiting CYP2C19
◉ Long term PPI usage.
Answer: >1 year increase risk of fractures, lower B12, impair
absorption of Ca carbonate (pt should take citrate), lower
magnesium
◉ Prostaglandins.
Answer: produced by gastric mucosa, inhibits secretion of acid and
stimulates secretion of mucus and HCO3.
◉ Misoprostol (Cytotec).
Answer: Prostaglandin: approved for prevention of NSAID induced
ulcers- contraindicated in pregnancy d/t miscarriage
◉ Antacids (MOA).
Answer: increase gastric pH
decrease pepsin activity (inactive at pH>4)
can cause metabolic alkalosis & produce significant Na+ loads.
Give pc (after) meals
◉ Mucosal Protective Agents.
EXAM SCRIPT 2026 FULL QUESTIONS AND
CORRECT ANSWERS
◉ COC (combined oral contraceptives).
Answer: increased cervical cancer risk
decreased endometrial/ovarian cancer risk
contraindicated in CVA
thromboembolic
contraindicated with estrogen dependent cancers, liver disease,
pregnancy, >35 smokers
◉ Androgens.
Answer: steroids with anabolic effects
testosterone- ineffective orally
fluoxymesterone- hypogonadism- oral
oxandrolone- chronic wasting d/t HIV or cancer-oral
donazol- endometriosis and fibrocystic breast disease
◉ Antiandrogens.
Answer: counteract male hormonal action.
,Finasteride/ dutasteride- inhibit 5-alpha reductast, used to treat
BPH.
flutamaide, bicalutamide, enzalutamide, nilutamide- treat prostate
cancer.
◉ Alternative to HRT.
Answer: SSRI (paroxetine), SNRI, clonidine, gabapentin
◉ PUD (peptic ulcer disease).
Answer: Main causes: gram (-) H. pylori & NSAIDS
drugs used: amoxicillin, bismuth, clarithromycin, metronidazole,
tetracycline. >90% treated with quad therapy (pesto, flagyl,
tetracycline, PPI) X 1wk
◉ H2 blockers MOA.
Answer: reduce secretion of acid. competitive antagonist of
histamine that are fully reveersible. Can cross placenta. Renal dose
adjustment needed.
◉ Cimetidine (Tagamet).
Answer: H2 blocker.
inhibits CYP450 and will interfere with metabolism of warfarin,
phenytoin, plavix.
,◉ H2 blockers.
Answer: Cimetidine
Famotidine
Nizatidine
Ranitidine
◉ PPI MOA.
Answer: suppress secretion of H+ ions by binding to H+/K+ ATPase
enzymes.
Used as 1st line treatment for GERD with severe heartburn.
acid-resistant coating, breaks down in alkaline duodenum, absorbed
in parietal cells.
Take 30-60 minutes before breakfast.
◉ PPI drugs (-prazole).
Answer: Lansoprazole (Prevacid)
dexlansoprazole
omeprazole (Prilosec)
esmeprazole (Nexium)
pantoprazole
rabeprazole
, ◉ Prilosec and Nexium.
Answer: decrease effectiveness of plavix by inhibiting CYP2C19
◉ Long term PPI usage.
Answer: >1 year increase risk of fractures, lower B12, impair
absorption of Ca carbonate (pt should take citrate), lower
magnesium
◉ Prostaglandins.
Answer: produced by gastric mucosa, inhibits secretion of acid and
stimulates secretion of mucus and HCO3.
◉ Misoprostol (Cytotec).
Answer: Prostaglandin: approved for prevention of NSAID induced
ulcers- contraindicated in pregnancy d/t miscarriage
◉ Antacids (MOA).
Answer: increase gastric pH
decrease pepsin activity (inactive at pH>4)
can cause metabolic alkalosis & produce significant Na+ loads.
Give pc (after) meals
◉ Mucosal Protective Agents.
