RAAS Pharmacology Examination
1. Which enzyme is responsible for the rate-limiting step in the formation of angiotensin II?
A. Angiotensin-converting enzyme (ACE)
B. Renin
C. Kinase II
D. Aldosterone synthase
2. Angiotensin II causes a rise in blood pressure primarily through which two mechanisms?
A. Vasodilation and sodium excretion
B. Vasoconstriction and stimulation of aldosterone release
C. Bronchodilation and potassium retention
D. Decreasing sympathetic outflow and increasing renal blood flow
3. Which statement regarding the types of angiotensin is correct?
A. Angiotensin I has strong biologic activity.
B. Angiotensin II is the precursor to Angiotensin I.
C. Angiotensin III has moderate biologic activity and is formed by the degradation of
Angiotensin II.
D. Angiotensinogen is a small polypeptide formed in the lungs.
4. Where is Angiotensin-Converting Enzyme (ACE) primarily located?
A. The adrenal cortex
B. The juxtaglomerular cells of the kidney
C. The luminal surface of all blood vessels, especially in the lungs
D. The distal tubules of the nephron
, 5. What is the effect of aldosterone on the kidneys?
A. Excretion of sodium and retention of potassium
B. Retention of sodium and water, and excretion of potassium and hydrogen
C. Decreased blood volume and blood pressure
D. Selective excretion of glucose and calcium
6. Which of the following is a "Black Box Warning" associated with ACE inhibitors, ARBs,
and DRIs?
A. Severe rebound hypertension
B. Fetal injury during the second and third trimesters
C. Irreversible ototoxicity
D. Hepatotoxicity in older adults
7. A patient taking an ACE inhibitor develops a dry, hacking cough. What is the
physiological cause of this side effect?
A. Accumulation of Angiotensin I
B. Accumulation of Bradykinin
C. Deficiency of aldosterone
D. Increased renin activity
8. Which ACE inhibitor is the only one available for intravenous (IV) administration?
A. Lisinopril
B. Captopril
C. Enalaprilat
D. Ramipril
1. Which enzyme is responsible for the rate-limiting step in the formation of angiotensin II?
A. Angiotensin-converting enzyme (ACE)
B. Renin
C. Kinase II
D. Aldosterone synthase
2. Angiotensin II causes a rise in blood pressure primarily through which two mechanisms?
A. Vasodilation and sodium excretion
B. Vasoconstriction and stimulation of aldosterone release
C. Bronchodilation and potassium retention
D. Decreasing sympathetic outflow and increasing renal blood flow
3. Which statement regarding the types of angiotensin is correct?
A. Angiotensin I has strong biologic activity.
B. Angiotensin II is the precursor to Angiotensin I.
C. Angiotensin III has moderate biologic activity and is formed by the degradation of
Angiotensin II.
D. Angiotensinogen is a small polypeptide formed in the lungs.
4. Where is Angiotensin-Converting Enzyme (ACE) primarily located?
A. The adrenal cortex
B. The juxtaglomerular cells of the kidney
C. The luminal surface of all blood vessels, especially in the lungs
D. The distal tubules of the nephron
, 5. What is the effect of aldosterone on the kidneys?
A. Excretion of sodium and retention of potassium
B. Retention of sodium and water, and excretion of potassium and hydrogen
C. Decreased blood volume and blood pressure
D. Selective excretion of glucose and calcium
6. Which of the following is a "Black Box Warning" associated with ACE inhibitors, ARBs,
and DRIs?
A. Severe rebound hypertension
B. Fetal injury during the second and third trimesters
C. Irreversible ototoxicity
D. Hepatotoxicity in older adults
7. A patient taking an ACE inhibitor develops a dry, hacking cough. What is the
physiological cause of this side effect?
A. Accumulation of Angiotensin I
B. Accumulation of Bradykinin
C. Deficiency of aldosterone
D. Increased renin activity
8. Which ACE inhibitor is the only one available for intravenous (IV) administration?
A. Lisinopril
B. Captopril
C. Enalaprilat
D. Ramipril
