Test Bank for Cellular and Molecular Immunology (10th Edition) by Abul K. Abbas, Andrew H. Lichtman, and Shiv Pillai.

TEST BANKk




Cellular and Molecular Immunology
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Abul Abbas, Andrew Lichtman, and Shiv Pillai
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10th Edition
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,Table of Contents
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Chapter 01 Properties and Overview of Immune Responses
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Chapter 02 Cells and Tissues of the Immune System
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Chapter 03 Leukocyte Circulation and Migration Into Tissues
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Chapter 04 Innate Immunity
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Chapter 05 Antibodies and Antigens
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Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
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Histocompatibility Complex Moleculesk k 20
Chapter 07 Immune Receptors and Signal Transduction
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Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
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Chapter 09 Activation of T Lymphocytes
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Chapter k 10 Differentiation and Functions of CD4+ Effector T Cells
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Chapter k 11 Differentiation and Functions of CD8+ Effector T Cells
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Chapter k 12 B Cell Activation and Antibody Production
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Chapter k 13 Effector Mechanisms of Humoral Immunity
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Chapter k 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
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Chapter k 15 Immunologic Tolerance and Autoimmunity
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Chapter k 16 Immunity to Microbes
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Chapter k 17 k Transplantation Immunology k 72
Chapter k 18 k Tumor Immunology
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Chapter k 19 k Hypersensitivity Disorders k 81
Chapter k 20 k Allergy 86
Chapter k 21 k Primary and Acquired Immunodeficiencies
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,Chapter 01: Properties and Overview of Immune Responses
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Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
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MULTIPLE CHOICE k




1. The principal function of the immune system is:
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a. Defense against cancer k k



b. Repair of injured tissues k k k



c. Defense against microbial infections k k k



d. Prevention of inflammatory diseases k k k



e. Protection against environmental toxins k k k




ANS: C
The immune system has evolved in the setting of selective pressures imposed by
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microbial infections. Although immune responses to cancer may occur, the concept that
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―immunosurveillance‖ against cancer is a principal function of the immune system is
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controversial. Repair of injured tissues may be a secondary consequence of the
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immune responses and inflammation. Although the immune system has regulatory features
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that are needed to prevent excessive inflammation, prevention of inflammatory
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diseases is not a
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primary function. The immune system can protect against microbial toxins, but it generally
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does not offer protection against toxins of nonbiologic origin.
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2. Which of the following infectious diseases was prevented by the first
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successful vaccination?
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a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C
In 1798, Edward Jenner reported the first intentional successful vaccination, which
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was against smallpox in a boy, using material from the cowpox pustules of a milkmaid.
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In 1980, smallpox was reported to be eradicated worldwide by a vaccination
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program.
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Effective vaccines against tetanus toxin, rubella virus, and poliovirus were developed
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in the 20th century and are widely used. There is no effective vaccine against
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Mycobacterium tuberculosis.
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3. Which of the following is a unique property of the adaptive immune system?
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a. Highly diverse repertoire of specificities for antigens k k k k k k



b. Self-nonself discrimination k



c. Recognition of microbial structures by both cell-associated and soluble receptors k k k k k k k k k



d. Protection against viral infections k k k



e. Responses that have the same kinetics and magnitude on repeated exposure to the k k k k k k k k k k k k



same microbe k k




ANS: A

, Highly diverse repertoires of specificities for antigens are found only in T and B
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lymphocytes, which are the central cellular components of the adaptive immune
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system. Both the innate and the adaptive immune systems use cell-associated and
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soluble receptors to recognize microbes, display some degree of self-nonself
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discrimination, and protect against viruses. On repeated exposure to the same microbe,
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the adaptive immune response becomes more rapid and of greater magnitude; this
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is the manifestation of memory.
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4. Antibodies and T lymphocytes are the respective mediators of which two types of
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immunity?
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a. Innate and adaptive k k



b. Passive and active k k



c. Specific and nonspecific k k



d. Humoral and cell-mediated k k



e. Adult and neonatal k k




ANS: D
Both B and T lymphocytes are principal components of adaptive immunity. B
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lymphocytes produce antibodies, which are the recognition and effector molecules of
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k humoral immune responses to extracellular pathogens. T cells recognize and promote
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k eradication of intracellular pathogens in cell-mediated immunity. Passive and active k k k k k k k k k



immunity both can be mediated by either B or T lymphocytes. Specific immunity
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kis another term for adaptive immunity. Both B and T lymphocytes participate in
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kadult adaptive immunity but are still developing in the neonatal period.
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5. The two major functional classes of effector T lymphocytes are:
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a. Helper T lymphocytes and cytotoxic T lymphocytes k k k k k k




b. Natural killer cells and cytoWtoWxW
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cyStes k k k k



c. Memory T cells and effector T cells k k k k k k



d. Helper cells and antigen-presenting cells k k k k



e. Cytotoxic T lymphocytes and target cells k k k k k




ANS: A
T cells can be classified into effector subsets that perform different effector functions.
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Most effector T cells are either helper T lymphocytes, which enhance the responses
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of other immune cells, including phagocytes and B cells, to infections, or
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cytotoxic T lymphocytes, which directly kill infected cells. Natural killer cells are
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not T lymphocytes.
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Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. k k k k k k k k k k k k k k




6. Which of the following cell types is required for all adaptive humoral immune responses?
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a. Natural killer cells k k



b. Dendritic cells k



c. Cytolytic T lymphocytes k k



d. B lymphocytes k



e. Helper T lymphocytes k k




ANS: D
Humoral immune responses are antibody-mediated immune responses, and all antibodies
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are made by B lymphocytes and no other cell type.
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