Page 1 of 128
PHARMACOLOGY HESI V2 EXAM 2026-
2027: NEWEST COMPLETE QUESTIONS
WITH 100% CORRECT ANSWERS &
VERIFIED EXPLANATIONS | GRADED
A+ – GUARANTEED SUCCESS ON FIRST
ATTEMPT | HIGH-YIELD STUDY GUIDE
A client is prescribed phenobarbital sodium
(Luminal) for a seizure disorder. The medication has
a long half-life of 4 days. Based on this half-life, the
medication will most likely be prescribed
A. once a day.
B. twice a day.
C. three times a day.
D. four times a day. >>>ANS: A
RATIONALE: Medication with long half-lives
remain at their therapeutic levels between doses for
long periods of time. Therefore, this medication can
be administered once a day.
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A nurse educator is reviewing medication dosages
and factors that influence medication metabolism
with a group of nurses. Medication dosages may
need to be decreased for which of the following
reasons? (Select all that apply.)
A. Increased renal excretion
B. Increased medication-metabolizing enzymes
C. Liver failure
D. Peripheral vascular disease
E. Concurrent use of medication metabolized by the
same pathway >>>ANS: C, E
RATIONALE: Liver failure decreases metabolism
and thus increase the concentration of medication.
This may require decreasing the dosage of
medication. When two medications are metabolized
in the same way, they may compete for metabolism,
thereby increasing the concentration of one or both
medications.
Increased renal excretion may decrease
concentration of the medication, requiring increased
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dosage. Increased medication-metabolizing enzymes
can decrease the concentration of the medication.
The dose might need increased. Peripheral vascular
disease may impair distribution, and more of the
medication may be needed.
A nurse s preparing to administer eye drops to a
client. Which of the following are appropriate
nursing interventions related to this procedure?
(Select all that apply.)
A. Using medical aseptic technique
B. Asking the client to look up at the ceiling
C. Having the client lie in a side-lying position
D. Dropping medication into the center of the
client's conjunctival sac
E. Instructing the client to close the eye gently
>>>ANS:B, D, E
RATIONALE: The medication should be dropped
into the center of the conjunctival sac to promote
better distribution of the medication. The client
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should close the eye gently to allow improved
distribution of the medication.
Surgical aseptic technique is used to administer eye
drops. The client should be sitting or in a supine
position to facilitate proper administration of eye
drops.
A nurse is completing discharge teaching to a client
who has a new prescription for a transdermal
medication. Which of the following statements by
the client indicates understanding of the teaching?
A. "I will clean the site with an alcohol swab prior to
applying the patch."
B. "I will rotate the application site weekly."
C. "I will apply the patch to an area of skin with no
hair."
D. "I will place the new patch on the site of the old
patch." >>>ANS: C
PHARMACOLOGY HESI V2 EXAM 2026-
2027: NEWEST COMPLETE QUESTIONS
WITH 100% CORRECT ANSWERS &
VERIFIED EXPLANATIONS | GRADED
A+ – GUARANTEED SUCCESS ON FIRST
ATTEMPT | HIGH-YIELD STUDY GUIDE
A client is prescribed phenobarbital sodium
(Luminal) for a seizure disorder. The medication has
a long half-life of 4 days. Based on this half-life, the
medication will most likely be prescribed
A. once a day.
B. twice a day.
C. three times a day.
D. four times a day. >>>ANS: A
RATIONALE: Medication with long half-lives
remain at their therapeutic levels between doses for
long periods of time. Therefore, this medication can
be administered once a day.
, Page 2 of 128
A nurse educator is reviewing medication dosages
and factors that influence medication metabolism
with a group of nurses. Medication dosages may
need to be decreased for which of the following
reasons? (Select all that apply.)
A. Increased renal excretion
B. Increased medication-metabolizing enzymes
C. Liver failure
D. Peripheral vascular disease
E. Concurrent use of medication metabolized by the
same pathway >>>ANS: C, E
RATIONALE: Liver failure decreases metabolism
and thus increase the concentration of medication.
This may require decreasing the dosage of
medication. When two medications are metabolized
in the same way, they may compete for metabolism,
thereby increasing the concentration of one or both
medications.
Increased renal excretion may decrease
concentration of the medication, requiring increased
, Page 3 of 128
dosage. Increased medication-metabolizing enzymes
can decrease the concentration of the medication.
The dose might need increased. Peripheral vascular
disease may impair distribution, and more of the
medication may be needed.
A nurse s preparing to administer eye drops to a
client. Which of the following are appropriate
nursing interventions related to this procedure?
(Select all that apply.)
A. Using medical aseptic technique
B. Asking the client to look up at the ceiling
C. Having the client lie in a side-lying position
D. Dropping medication into the center of the
client's conjunctival sac
E. Instructing the client to close the eye gently
>>>ANS:B, D, E
RATIONALE: The medication should be dropped
into the center of the conjunctival sac to promote
better distribution of the medication. The client
, Page 4 of 128
should close the eye gently to allow improved
distribution of the medication.
Surgical aseptic technique is used to administer eye
drops. The client should be sitting or in a supine
position to facilitate proper administration of eye
drops.
A nurse is completing discharge teaching to a client
who has a new prescription for a transdermal
medication. Which of the following statements by
the client indicates understanding of the teaching?
A. "I will clean the site with an alcohol swab prior to
applying the patch."
B. "I will rotate the application site weekly."
C. "I will apply the patch to an area of skin with no
hair."
D. "I will place the new patch on the site of the old
patch." >>>ANS: C
