Biotherapy - ANSWER Targeted anticancer agents also known as biological response
modifiers (BRM)
Tyrosine kinase inhibitors (TKIs) are what class - ANSWER Biotherapy
Monoclonal antibodies (MoAbs) are what class - ANSWER Biotherapy
Define pharmacokinetics - ANSWER Study of drug absorption, metabolism, and excretion
Define pharmacodynamics - ANSWER The concentration of the drug in the body and how
it produces a response
Define adjuvant chemotherapy - ANSWER The use of chemo after another type of
therapy, such as surgery, to treat residual disease or undetectable metastasis.
Define neoadjuvant chemotherapy - ANSWER When chemo is used preoperatively to
decrease tumor burden in order to make it easier to remove the tumor surgically.
Define sanctuary sites - ANSWER Sites within the body where tumor cells sequester and
are not easily reached by chemo such as the CNS
What normal cells are most often effected by chemotherapy - ANSWER Hematopoietic,
mucosal (mouth & GI), hair follicles
1
, Why use chemotherapy - ANSWER To prevent cancer cells from dividing, metastasizing,
and ultimately causing the death of the patient
Cure - ANSWER To permanently eradicate the cancer
Control - ANSWER To extend the length & QOL when cure is not feasible or realistic
Palliation - ANSWER Minimize pain and suffering during end of life
Resting phase of cell cycle - ANSWER Gap 0 - cells not dividing
Postmitotic phase - ANSWER Gap 1 - enzymes needed for DNA synthesis are produced,
protein and RNA synthesis takes place (18 Hours)
Synthesis (S) Phase - ANSWER Cellular DNA duplicated (20 hours)
Premitotic phase - ANSWER Gap 2 - both protein and RNA synthesis occur, precursors of
mitotic spindle are produced. Shortest phase
Mitosis (M) Phase - ANSWER Cell division occurs in 4-step phase (prophase, metaphase,
anaphase, telophase) 1 Hour
5 stages of reproduction of cells - ANSWER Resting, Postmitotic, synthesis, premitotic,
mitosis
Cell Cycle time - ANSWER The amount of time it takes a cell to move from one mitotic
episode to another.
2
modifiers (BRM)
Tyrosine kinase inhibitors (TKIs) are what class - ANSWER Biotherapy
Monoclonal antibodies (MoAbs) are what class - ANSWER Biotherapy
Define pharmacokinetics - ANSWER Study of drug absorption, metabolism, and excretion
Define pharmacodynamics - ANSWER The concentration of the drug in the body and how
it produces a response
Define adjuvant chemotherapy - ANSWER The use of chemo after another type of
therapy, such as surgery, to treat residual disease or undetectable metastasis.
Define neoadjuvant chemotherapy - ANSWER When chemo is used preoperatively to
decrease tumor burden in order to make it easier to remove the tumor surgically.
Define sanctuary sites - ANSWER Sites within the body where tumor cells sequester and
are not easily reached by chemo such as the CNS
What normal cells are most often effected by chemotherapy - ANSWER Hematopoietic,
mucosal (mouth & GI), hair follicles
1
, Why use chemotherapy - ANSWER To prevent cancer cells from dividing, metastasizing,
and ultimately causing the death of the patient
Cure - ANSWER To permanently eradicate the cancer
Control - ANSWER To extend the length & QOL when cure is not feasible or realistic
Palliation - ANSWER Minimize pain and suffering during end of life
Resting phase of cell cycle - ANSWER Gap 0 - cells not dividing
Postmitotic phase - ANSWER Gap 1 - enzymes needed for DNA synthesis are produced,
protein and RNA synthesis takes place (18 Hours)
Synthesis (S) Phase - ANSWER Cellular DNA duplicated (20 hours)
Premitotic phase - ANSWER Gap 2 - both protein and RNA synthesis occur, precursors of
mitotic spindle are produced. Shortest phase
Mitosis (M) Phase - ANSWER Cell division occurs in 4-step phase (prophase, metaphase,
anaphase, telophase) 1 Hour
5 stages of reproduction of cells - ANSWER Resting, Postmitotic, synthesis, premitotic,
mitosis
Cell Cycle time - ANSWER The amount of time it takes a cell to move from one mitotic
episode to another.
2
