T/F Chemotherapy consenting is to be performed by the patient's attending physician -
ANSWER True
A ________ consent is required if the chemo is being used in a new way and/or a new drug
is added to the regimen. - ANSWER New
T/F A patient can leave their shoes on when height and weight are obtained ONLY if the
patient is suffering from peripheral neuropathy. - ANSWER False
Who determines if actual, ideal, or adjusted body weight is to be used in chemo dosing? -
ANSWER Physician
The Calvert formula is used to calculate the dose of what drug? - ANSWER Carboplatin
What does the AUC measure? - ANSWER Area under the curve/drug exposure
T/F Mrs. S is receiving Carboplatin dosed with an AUC of 6 and Mrs. H is receiving
Carboplatin with AUC of 2. The nurse knows Mrs. S. may have more toxicity to the drug since
her AUC is higher than Mrs. H. - ANSWER True
A UPMC fellow cannot write orders independently in the first _________ - ANSWER 3
months
_____________ chemotherapy administered IV push should be administered at a rate of
5mL/minute and blood return should be assessed after every _____mL of drug
administered. - ANSWER Vesicant, 3
1
,T/F The most accurate method to measure creatinine clearance is to collect urine for 24
hours to measure level - ANSWER True
T/F When administering an IV push med, the nurse should open the clamp of compatible IV
solution until increased flow is seen to dilute the agent during administration. - ANSWER
True
During the 2 RN check, the correct patient and dose is to be verified at the ______ -
ANSWER bedside/chairside
Continuous infusion of vesicants must be through a ________ - ANSWER central line
Excretion safety precautions last for ____ to _____ days. - ANSWER 3-7
T/F When evaluating a patient prior to chemo, the nurse notes the patient recently had
weight loss. The nurse recalculates the dose and discovers a change in the dose greater than
10%. The next step for the nurse is to notify the attending physician that the patient will
need re-consented because of the dose adjustment - ANSWER False
Alkylating agents are cell cycle non-specific. They work on _____ and resting cells. -
ANSWER dividing
Alkylating agents are effective in slow growing tumors and large tumors that have few
actively ________ - ANSWER dividing cells
List 3 toxicities common in all alkylating agents - ANSWER Nausea, vomiting,
myelosuppression, infertility, hypersensitivity reactions, alopecia, secondary malignancies,
tumor lysis synndrome, pregnance category D
2
, Which class of drugs can cross the blood brain barrier, increasing a patient's risk for CNS
toxicities - ANSWER nitrosureas
The solvent for carmustine (BCNU) - ANSWER Sterile alcohol
The ________ formula is used to calculate Carboplatin dosage - ANSWER Calvert
T/F Temozalamide (Temodor) effectively crosses the blood brain barrier - ANSWER True
patients may feel intoxicated during the administration of ______ - ANSWER Carmustine
(BCNU)
Patients are prophylictically medicated with anticonvulsants before receiving _________ and
24 hours after the last dose to prevent seizures - ANSWER Busulfan
T/F Oxaliplatin should only be mixed with D5W - ANSWER True
Which drug should ALWAYS be given with Mesna - ANSWER Ifosfamide
Pulmonary fibrosis is a late complication of patients who receive ________ - ANSWER
Busulfan
The platinum alkylating agents include ______, ______, and _______. - ANSWER
Cisplatin, Carboplatin, and Oxaliplatin
Cisplatin (Platinol) is a _________ emetogenic drug. - ANSWER highly
Pretreatment hydration is administered to prevent this toxicity of cisplatin - ANSWER
Nephrotoxicity
3
ANSWER True
A ________ consent is required if the chemo is being used in a new way and/or a new drug
is added to the regimen. - ANSWER New
T/F A patient can leave their shoes on when height and weight are obtained ONLY if the
patient is suffering from peripheral neuropathy. - ANSWER False
Who determines if actual, ideal, or adjusted body weight is to be used in chemo dosing? -
ANSWER Physician
The Calvert formula is used to calculate the dose of what drug? - ANSWER Carboplatin
What does the AUC measure? - ANSWER Area under the curve/drug exposure
T/F Mrs. S is receiving Carboplatin dosed with an AUC of 6 and Mrs. H is receiving
Carboplatin with AUC of 2. The nurse knows Mrs. S. may have more toxicity to the drug since
her AUC is higher than Mrs. H. - ANSWER True
A UPMC fellow cannot write orders independently in the first _________ - ANSWER 3
months
_____________ chemotherapy administered IV push should be administered at a rate of
5mL/minute and blood return should be assessed after every _____mL of drug
administered. - ANSWER Vesicant, 3
1
,T/F The most accurate method to measure creatinine clearance is to collect urine for 24
hours to measure level - ANSWER True
T/F When administering an IV push med, the nurse should open the clamp of compatible IV
solution until increased flow is seen to dilute the agent during administration. - ANSWER
True
During the 2 RN check, the correct patient and dose is to be verified at the ______ -
ANSWER bedside/chairside
Continuous infusion of vesicants must be through a ________ - ANSWER central line
Excretion safety precautions last for ____ to _____ days. - ANSWER 3-7
T/F When evaluating a patient prior to chemo, the nurse notes the patient recently had
weight loss. The nurse recalculates the dose and discovers a change in the dose greater than
10%. The next step for the nurse is to notify the attending physician that the patient will
need re-consented because of the dose adjustment - ANSWER False
Alkylating agents are cell cycle non-specific. They work on _____ and resting cells. -
ANSWER dividing
Alkylating agents are effective in slow growing tumors and large tumors that have few
actively ________ - ANSWER dividing cells
List 3 toxicities common in all alkylating agents - ANSWER Nausea, vomiting,
myelosuppression, infertility, hypersensitivity reactions, alopecia, secondary malignancies,
tumor lysis synndrome, pregnance category D
2
, Which class of drugs can cross the blood brain barrier, increasing a patient's risk for CNS
toxicities - ANSWER nitrosureas
The solvent for carmustine (BCNU) - ANSWER Sterile alcohol
The ________ formula is used to calculate Carboplatin dosage - ANSWER Calvert
T/F Temozalamide (Temodor) effectively crosses the blood brain barrier - ANSWER True
patients may feel intoxicated during the administration of ______ - ANSWER Carmustine
(BCNU)
Patients are prophylictically medicated with anticonvulsants before receiving _________ and
24 hours after the last dose to prevent seizures - ANSWER Busulfan
T/F Oxaliplatin should only be mixed with D5W - ANSWER True
Which drug should ALWAYS be given with Mesna - ANSWER Ifosfamide
Pulmonary fibrosis is a late complication of patients who receive ________ - ANSWER
Busulfan
The platinum alkylating agents include ______, ______, and _______. - ANSWER
Cisplatin, Carboplatin, and Oxaliplatin
Cisplatin (Platinol) is a _________ emetogenic drug. - ANSWER highly
Pretreatment hydration is administered to prevent this toxicity of cisplatin - ANSWER
Nephrotoxicity
3
