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Exam Solution zm
GI Pharmacology Lippincott's QA 2026 A+ GRADE ASSU
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RED COMPLETE SOLUTIONS AND VERIFIED ANSWERS (
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8F5AB)
QUESTION 1 zm
A 49-year-old man with a history of peptic ulcer dis-
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ease and gastroesophageal reflux disorder is being treated with cimetidine for appro
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ximately 20 years. He now complains of breast swelling and breast discharge. What is
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the most likely explanation for these findings? (
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A) Abscess (
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B) Antiandrogenic effect (
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C) Inflammatory response (
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D) Neoplastic process (
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E) Overwhelming edema
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ANSWER
B: Antiandrogenic effect. Cimetidine can also have endocrine effects because it acts as a nonsteroidal
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mantiandrogen. These effects include gynecomastia and galactorrhea (continuous release/discharge of
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milk). Drugs such as ketoconazole, which depend on an acidic medium for gastric absorption, may n
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ot be efficiently absorbed if taken with one of these H2 receptor antagonists. (
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A) Cimetidine is associated with endocrine effects such as breast swelling and tenderness. This is no
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t caused by an abscess. (
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C) This process is not inflammatory in nature. This process is an endocrine side effect of cimetidine.
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D) This patient has no evidence by history of examination to suggest breast cancer. (
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E) This is an overgrowth of breast tissue, not a buildup of interstitial fluid in the chest.
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QUESTION 2 zm
A 34-year-
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old man with a sacral spinal cord injury has neurogenic bowel. He is on a bowel regi
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men that involves periodic bowel cleansing with soapsuds enemas. He is given a trial
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of bethanechol for this condition. Which of the following adverse events must his trea
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ting physician be aware of? (
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A) Bronchodilation (
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Exam Solution zm
GI Pharmacology Lippincott's QA 2026 A+ GRADE ASSU
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RED COMPLETE SOLUTIONS AND VERIFIED ANSWERS (
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8F5AB)
QUESTION 1 zm
A 49-year-old man with a history of peptic ulcer dis-
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ease and gastroesophageal reflux disorder is being treated with cimetidine for appro
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ximately 20 years. He now complains of breast swelling and breast discharge. What is
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the most likely explanation for these findings? (
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A) Abscess (
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B) Antiandrogenic effect (
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C) Inflammatory response (
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D) Neoplastic process (
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E) Overwhelming edema
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ANSWER
B: Antiandrogenic effect. Cimetidine can also have endocrine effects because it acts as a nonsteroidal
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mantiandrogen. These effects include gynecomastia and galactorrhea (continuous release/discharge of
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milk). Drugs such as ketoconazole, which depend on an acidic medium for gastric absorption, may n
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ot be efficiently absorbed if taken with one of these H2 receptor antagonists. (
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A) Cimetidine is associated with endocrine effects such as breast swelling and tenderness. This is no
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t caused by an abscess. (
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C) This process is not inflammatory in nature. This process is an endocrine side effect of cimetidine.
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D) This patient has no evidence by history of examination to suggest breast cancer. (
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E) This is an overgrowth of breast tissue, not a buildup of interstitial fluid in the chest.
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QUESTION 2 zm
A 34-year-
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old man with a sacral spinal cord injury has neurogenic bowel. He is on a bowel regi
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men that involves periodic bowel cleansing with soapsuds enemas. He is given a trial
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of bethanechol for this condition. Which of the following adverse events must his trea
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ting physician be aware of? (
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A) Bronchodilation (
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