MSN 671 NEI GLOBAL VIDEO QUESTIONS
2026 EXAM PREP STUDY SHEET ACCURATE
QUESTIONS AND ANSWERS GRADED A+
⩥ Voltage-sensitive ion channels.
Answer: Activated by changes in membrane voltage or charge.
⩥ Ionotropic receptors.
Answer: Another name for ligand-gated ion channels.
⩥ Clinical relevance of ligand-gated vs voltage-sensitive channels.
Answer: LGICs → rapid effects (e.g., benzodiazepines, ketamine);
VSSCs/VSCCs → anticonvulsants, mood stabilizers, analgesics.
⩥ Dual role of ligand-gated ion channels.
Answer: They act as both receptors and ion channels.
⩥ Structure of LGICs.
Answer: Several subunits arranged around an ion channel with binding
sites for NTs, drugs, ions, and allosteric modulators.
⩥ Pentameric receptors.
, Answer: Receptors with 5 subunits.
⩥ Tetrameric receptors.
Answer: Receptors with 4 subunits + re-entrant loop.
⩥ Examples of pentameric receptors.
Answer: GABAA_AA, Nicotinic acetylcholine receptor (nAChR), 5-
HT3, Glycine receptor.
⩥ Examples of tetrameric receptors.
Answer: AMPA, NMDA, Kainate (glutamate receptors).
⩥ Pentameric LGIC subtypes.
Answer: GABAA_AA, nAChR, 5-HT3, Glycine receptors.
⩥ Tetrameric LGIC subtypes.
Answer: AMPA, Kainate, NMDA.
⩥ Assembly of pentameric receptors.
Answer: 5 subunits form a functional ion channel; subunit composition
defines receptor subtype.
2026 EXAM PREP STUDY SHEET ACCURATE
QUESTIONS AND ANSWERS GRADED A+
⩥ Voltage-sensitive ion channels.
Answer: Activated by changes in membrane voltage or charge.
⩥ Ionotropic receptors.
Answer: Another name for ligand-gated ion channels.
⩥ Clinical relevance of ligand-gated vs voltage-sensitive channels.
Answer: LGICs → rapid effects (e.g., benzodiazepines, ketamine);
VSSCs/VSCCs → anticonvulsants, mood stabilizers, analgesics.
⩥ Dual role of ligand-gated ion channels.
Answer: They act as both receptors and ion channels.
⩥ Structure of LGICs.
Answer: Several subunits arranged around an ion channel with binding
sites for NTs, drugs, ions, and allosteric modulators.
⩥ Pentameric receptors.
, Answer: Receptors with 5 subunits.
⩥ Tetrameric receptors.
Answer: Receptors with 4 subunits + re-entrant loop.
⩥ Examples of pentameric receptors.
Answer: GABAA_AA, Nicotinic acetylcholine receptor (nAChR), 5-
HT3, Glycine receptor.
⩥ Examples of tetrameric receptors.
Answer: AMPA, NMDA, Kainate (glutamate receptors).
⩥ Pentameric LGIC subtypes.
Answer: GABAA_AA, nAChR, 5-HT3, Glycine receptors.
⩥ Tetrameric LGIC subtypes.
Answer: AMPA, Kainate, NMDA.
⩥ Assembly of pentameric receptors.
Answer: 5 subunits form a functional ion channel; subunit composition
defines receptor subtype.
