MICB 4131 - EXAM -1 QUESTIONS AND VERIFIED ANSWERS

MICB 4131 - EXAM #1 QUESTIONS AND VERIFIED
ANSWERS


hematopoietic stem cells - Answers - Precursor to most immune cells, produced in bone
marrow
- Myeloid
- Lymphoid

myeloid stem cells - Answers - Gives rise to most innate immune cells:
PMNs: neutrophil, basophil, eosinophil
Monocytes -> macrophage
Mast cells
Megakaryocytes -> platelets
Erythrocytes

lymphoid stem cells - Answers - Gives rise to T cells, B cells, and NK cells (and some
dendritic cells)

Primary lymphoid organs - Answers - Where lymphocytes are made: Thymus and bone
marrow

Secondary lymphoid organs - Answers - Where mature/naive lymphocytes are
maintained, and adaptive immune responses are initiated: lymph nodes, spleen, Peyer's
patches

Where are naive T and B cells found - Answers - Blood, lymph, or secondary lymphoid
organs

Lymph Node Structure - Answers - - Primary lymphoid follicle: Consists of B cells and
follicular dendritic cells (precursor to germinal center)
- Germinal center: Where B cell adaptation occurs
- Paracortical area: Where T cells circulate, waiting to be presented with antigen
- Afferent lymphatic vessel: Lymph enters
- Efferent lymphatic vessel: Lymph exits

Peyer's Patches - Answers - - Epithelial layer of M cells (characterized by membrane
ruffles)
- Germinal centers
- T cell circulation
- Efferent lymphatics

Spleen - Answers - - Old RBC's are destroyed
- Germinal centers