MICB 4131 EXAM 2 STUDY GUIDE
IL-1 - Answers - induction of inflammation
IL-2 - Answers - secreted by T Cells, promotes B, T, NK and AICD proliferation
IL-4 - Answers - secreted by TH2 cells, promotes differentiation of T to TH2 cells and
isotype switch to IgE
IL-5 - Answers - secreted by TH2, activates and generates eosinophils
IL-7 - Answers - made by stromal cells, are required for survival of naive T and B cells
IL-15 - Answers - required for memory T cell survival
TNF-a - Answers - secreted by macrophages, causes inflammation and induces cell
death
IFN-b - Answers - secreted by all nucleated cells, induces antiviral state and MHC I
expression
IFN-g - Answers - secreted by TH1, CD8 and NK cells, activates macrophages,
increases antigen presentation and expression of MHC I and MHC II
TGF-b - Answers - secreted by T cells and macrophages, inhibits T cell and B cell
proliferation, promotes isotype switch to IgA
CD44 - Answers - Cell adhesion molecule, expressed in memory and effector T cells
CD26L - Answers - receptor for homing to lymph node
CCR7 - Answers - chemokine receptor for homing in naive B and T cells, binding
CCL21 and CCL19 produced by DC
BCL-2 - Answers - promotes cell survival
granzyme B - Answers - (2/2) effector molecule in cell killing by T cells
FasL - Answers - (1/2) effector molecule in cell killing by T cells
CD122 - Answers - part of receptor for IL-15 and IL-2
CD25 - Answers - part of receptor for IL-2
IL-1 - Answers - induction of inflammation
IL-2 - Answers - secreted by T Cells, promotes B, T, NK and AICD proliferation
IL-4 - Answers - secreted by TH2 cells, promotes differentiation of T to TH2 cells and
isotype switch to IgE
IL-5 - Answers - secreted by TH2, activates and generates eosinophils
IL-7 - Answers - made by stromal cells, are required for survival of naive T and B cells
IL-15 - Answers - required for memory T cell survival
TNF-a - Answers - secreted by macrophages, causes inflammation and induces cell
death
IFN-b - Answers - secreted by all nucleated cells, induces antiviral state and MHC I
expression
IFN-g - Answers - secreted by TH1, CD8 and NK cells, activates macrophages,
increases antigen presentation and expression of MHC I and MHC II
TGF-b - Answers - secreted by T cells and macrophages, inhibits T cell and B cell
proliferation, promotes isotype switch to IgA
CD44 - Answers - Cell adhesion molecule, expressed in memory and effector T cells
CD26L - Answers - receptor for homing to lymph node
CCR7 - Answers - chemokine receptor for homing in naive B and T cells, binding
CCL21 and CCL19 produced by DC
BCL-2 - Answers - promotes cell survival
granzyme B - Answers - (2/2) effector molecule in cell killing by T cells
FasL - Answers - (1/2) effector molecule in cell killing by T cells
CD122 - Answers - part of receptor for IL-15 and IL-2
CD25 - Answers - part of receptor for IL-2
