MICB 4131 EXAM 2 QUESTIONS AND VERIFIED
ANSWERS
There is only 1 type of effector CD4 T cell - Answers - false
Negative selection occurs in lymph nodes where most self antigen is found - Answers -
false
Positive selection is necessary to ensure your T cells can recognize foreign MHC -
Answers - false
Clonal expansion refers to - Answers - (none of the above)
Effector T cells are - Answers - antigen-experienced
Memory T cells are - Answers - antigen-experienced
B and T cell development occur in the bone marrow - Answers - false
IL-2 is made by naive T cells - Answers - false
B cell development is dependent on somatic hypermutation - Answers - false
Naïve T cells are enriched in these locations - Answers - Lymph nodes
Compared to naïve T cells, memory T cells express more - Answers - CD44
Tdt enzyme is important for - Answers - Junctional diversity within the antigen-binding
groove of lymphocyte receptors, Adding P or palindromic nucleotides, Adding N or non-
template encoded nucleotides
VDJ recombination occurs during B cell development and T cell development - Answers
- True
RSS (recombination signal sequences) are important during T cell priming - Answers -
False
CD3 performs a function similar to Iga/Igb - Answers - True
The transcription factor AIRE is important during - Answers - Negative selection
Mutations resulting in loss of function in RAG enzymes will result in - Answers - no B
cells and no T cells
ANSWERS
There is only 1 type of effector CD4 T cell - Answers - false
Negative selection occurs in lymph nodes where most self antigen is found - Answers -
false
Positive selection is necessary to ensure your T cells can recognize foreign MHC -
Answers - false
Clonal expansion refers to - Answers - (none of the above)
Effector T cells are - Answers - antigen-experienced
Memory T cells are - Answers - antigen-experienced
B and T cell development occur in the bone marrow - Answers - false
IL-2 is made by naive T cells - Answers - false
B cell development is dependent on somatic hypermutation - Answers - false
Naïve T cells are enriched in these locations - Answers - Lymph nodes
Compared to naïve T cells, memory T cells express more - Answers - CD44
Tdt enzyme is important for - Answers - Junctional diversity within the antigen-binding
groove of lymphocyte receptors, Adding P or palindromic nucleotides, Adding N or non-
template encoded nucleotides
VDJ recombination occurs during B cell development and T cell development - Answers
- True
RSS (recombination signal sequences) are important during T cell priming - Answers -
False
CD3 performs a function similar to Iga/Igb - Answers - True
The transcription factor AIRE is important during - Answers - Negative selection
Mutations resulting in loss of function in RAG enzymes will result in - Answers - no B
cells and no T cells
