Systems Biology of Cell Signaling
Recurring Themes and Quantitative
Questions and answers with Solutions
🧠 CORE PRACTICE QUESTIONS
SYSTEMS BIOLOGY OF CELL SIGNALING – STUDY GUIDE
🔹 Cell Signaling Basics
1. Cell signaling is best defined as:
A. DNA replication
B. Communication between cells using signals
C. Protein destruction
D. Cell death only
Answer: B
2. A ligand is:
A. A DNA molecule
B. A signaling molecule that binds a receptor
C. A lipid membrane
D. A protein enzyme only
Answer: B
3. Receptors are located:
,A. Only in nucleus
B. On membrane or inside cell
C. Only in blood
D. Only in mitochondria
Answer: B
🔹 Quantitative Modeling
4. Ordinary differential equations (ODEs) describe:
A. Static images
B. Change over time
C. Protein color
D. Cell shape only
Answer: B
5. In signaling models, rate constants represent:
A. Cell size
B. Speed of reactions
C. DNA length
D. Temperature only
Answer: B
6. A steady state occurs when:
A. No molecules exist
B. Input = output (no net change)
C. Cell dies
D. DNA mutates
Answer: B
🔹 Feedback Systems
7. Positive feedback causes:
A. Stability
B. Amplification
C. No change
, D. Inhibition only
Answer: B
8. Negative feedback causes:
A. Instability
B. Stability/homeostasis
C. Mutation
D. Cell death always
Answer: B
9. Biological switches are often:
A. Linear systems
B. Nonlinear systems
C. Random systems
D. No-feedback systems
Answer: B
🔹 Switches & Bistability
10. Bistability means:
A. One stable state
B. Two stable states
C. No state
D. Infinite states
Answer: B
11. A biological switch is useful for:
A. Gradual response
B. All-or-none response
C. No response
D. Random response
Answer: B
12. Hysteresis means:
A. Same input always gives same output
B. Output depends on history
C. No signal