Page 1 of 156
THERAPEUTIC MODALITIES CHAPTER 5
COMPLETE REVIEW 2026/27 GRADED A+
1. What is the correct order of the three phases of soft tissue
healing?
A) Remodeling → Inflammation → Proliferation
B) Inflammation → Proliferation → Remodeling
C) Proliferation → Inflammation → Remodeling
D) Inflammation → Remodeling → Proliferation
Answer: B
Rationale: Healing always begins with inflammation (days 0–
5), then proliferation (days 3–21), then remodeling (day 21
onward).
,Page 2 of 156
2. Which cell type is the first to arrive at an acute injury
site?
A) Fibroblasts
B) Macrophages
C) Neutrophils
D) Platelets
Answer: C
Rationale: Neutrophils arrive within minutes to hours to
phagocytose debris and bacteria.
3. During the inflammatory phase, which chemical mediator
causes vasodilation and increased capillary permeability?
A) Collagenase
B) Histamine
C) Proteoglycans
D) Elastin
,Page 3 of 156
Answer: B
Rationale: Histamine released from mast cells increases blood
flow and vascular permeability, causing edema.
4. True/False: The inflammatory response is always
pathological and should be completely suppressed.
Answer: False
Rationale: Inflammation is a necessary step for healing;
complete suppression can delay recovery.
5. A patient presents with an ankle sprain 2 hours ago.
What cardinal signs of inflammation would you
expect? (Select all that apply)
A) Rubor (redness)
B) Tumor (swelling)
C) Calor (heat)
D) Dolor (pain)
E) Functio laesa (loss of function)
, Page 4 of 156
Answer: A, B, C, D, E
Rationale: All five classic signs are present in acute
inflammation.
6. Scenario: An athlete sustained a hamstring strain 5 days
ago. Today, the area is less swollen but still tender. Which
phase of healing is likely beginning?
A) Acute inflammation
B) Proliferation
C) Remodeling
D) Chronic inflammation
Answer: B
Rationale: By day 5, inflammation subsides and fibroblast
activity (proliferation) increases.
7. Which growth factor is primarily responsible for
angiogenesis during proliferation?
A) PDGF (Platelet-derived growth factor)
B) TGF-β (Transforming growth factor beta)
THERAPEUTIC MODALITIES CHAPTER 5
COMPLETE REVIEW 2026/27 GRADED A+
1. What is the correct order of the three phases of soft tissue
healing?
A) Remodeling → Inflammation → Proliferation
B) Inflammation → Proliferation → Remodeling
C) Proliferation → Inflammation → Remodeling
D) Inflammation → Remodeling → Proliferation
Answer: B
Rationale: Healing always begins with inflammation (days 0–
5), then proliferation (days 3–21), then remodeling (day 21
onward).
,Page 2 of 156
2. Which cell type is the first to arrive at an acute injury
site?
A) Fibroblasts
B) Macrophages
C) Neutrophils
D) Platelets
Answer: C
Rationale: Neutrophils arrive within minutes to hours to
phagocytose debris and bacteria.
3. During the inflammatory phase, which chemical mediator
causes vasodilation and increased capillary permeability?
A) Collagenase
B) Histamine
C) Proteoglycans
D) Elastin
,Page 3 of 156
Answer: B
Rationale: Histamine released from mast cells increases blood
flow and vascular permeability, causing edema.
4. True/False: The inflammatory response is always
pathological and should be completely suppressed.
Answer: False
Rationale: Inflammation is a necessary step for healing;
complete suppression can delay recovery.
5. A patient presents with an ankle sprain 2 hours ago.
What cardinal signs of inflammation would you
expect? (Select all that apply)
A) Rubor (redness)
B) Tumor (swelling)
C) Calor (heat)
D) Dolor (pain)
E) Functio laesa (loss of function)
, Page 4 of 156
Answer: A, B, C, D, E
Rationale: All five classic signs are present in acute
inflammation.
6. Scenario: An athlete sustained a hamstring strain 5 days
ago. Today, the area is less swollen but still tender. Which
phase of healing is likely beginning?
A) Acute inflammation
B) Proliferation
C) Remodeling
D) Chronic inflammation
Answer: B
Rationale: By day 5, inflammation subsides and fibroblast
activity (proliferation) increases.
7. Which growth factor is primarily responsible for
angiogenesis during proliferation?
A) PDGF (Platelet-derived growth factor)
B) TGF-β (Transforming growth factor beta)
