TEST BANK –
CELLULAR AND MOLECULAR
IMMUNOLOGY, 11TH EDITION (ABBAS,
2026), CHAPTER 1-21 | ALL CHAPTERS
,Table of contents
1. Properties and overview of immune responses
2. Cells and tissues of the immune system
3. Leukocyte circulation and migration into tissues
4. Innate immunity
5. Antibodies and antigens
6. Antigen presentation to t lymphocytes and the functions of mhc molecules
7. Immune receptors and signal transduction
8. Lymphocyte development and antigen receptor gene rearrangement
9. Activation of t lymphocytes
10. Differentiation and functions of cd4+ effector t cells
11. Differentiation and functions of cd8+ effector t cells
12. B cell activation and antibody production
13. Effector mechanisms of humoral immunity
14. Specialized immunity at epithelial barriers and in immune privileged tissues
15. Immunologic tolerance and autoimmunity
16. Immunity to microbes
17. Transplantation immunology
18. Immunity to tumors
19. Hypersensitivity disorders
20. Allergy
21. Congenital and acquired immunodeficiencies
,Chapter 01: properties and overview of immune responses
Abbas, lichtman, and pillai: cellular and molecular immunology, 11th edition
Multiple choice
1. The principal function of the immune system is:
a. Defense against cancer
b. Repair of injured tissues
c. Defense against microbial infections
d. Prevention of inflammatory diseases
e. Protection against environmental toxins
Ans: c
The immune system has evolved in the setting of selective pressures imposed by
microbial infections. Although immune responses to cancer may occur, the concept
that “immunosurveillance” against cancer is a principal function of the immune
system is controversial. Repair of injured tissues may be a secondary consequence
of the immune responses and inflammation. Although the immune system has
regulatory features that are needed to prevent excessive inflammation, prevention
of inflammatory diseases is not a primary function. The immune system can protect
against microbial toxins, but it generally does not offer protection against toxins of
nonbiologic origin.
2. Which of the following infectious diseases was prevented by the first
successful vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
Ans: c
In 1798, edward jenner reported the first intentional successful vaccination, which
was against smallpox in a boy, using material from the cowpox pustules of a
milkmaid. In 1980, smallpox was reported to be eradicated worldwide by a
vaccination program. Effective vaccines against tetanus toxin, rubella virus, and
poliovirus were developed in the 20th century and are widely used. There is no
effective vaccine against mycobacterium tuberculosis.
3. Which of the following is a unique property of the adaptive immune system?
a. Highly diverse repertoire of specificities for antigens
b. Self-nonself discrimination
c. Recognition of microbial structures by both cell-associated and soluble receptors
d. Protection against viral infections
e. Responses that have the same kinetics and magnitude on repeated
exposure to the same microbe
Ans: a
, Highly diverse repertoires of specificities for antigens are found only in t and b
lymphocytes, which are the central cellular components of the adaptive immune
system. Both the innate and the adaptive immune systems use cell-associated and
soluble receptors to recognize microbes, display some degree of self-nonself
discrimination, and protect against viruses. On repeated exposure to the same
microbe, the adaptive immune response becomes more rapid and of greater
magnitude; this is the manifestation of memory.
4. Antibodies and t lymphocytes are the respective mediators of which two
types of immunity?
a. Innate and adaptive
b. Passive and active
c. Specific and nonspecific
d. Humoral and cell-mediated
e. Adult and neonatal
Ans: d
Both b and t lymphocytes are principal components of adaptive immunity. B
lymphocytes produce antibodies, which are the recognition and effector molecules of
humoral immune responses to extracellular pathogens. T cells recognize and promote
eradication of intracellular pathogens in cell-mediated immunity. Passive and active
immunity both can be mediated by either b or t lymphocytes. Specific immunity is
another term for adaptive immunity. Both b and t lymphocytes participate in adult
adaptive immunity but are still developing in the neonatal period.
5. The two major functional classes of effector t lymphocytes are:
a. Helper t lymphocytes and cytotoxic t lymphocytes
b. Natural killer cells and cytowtowxw
ic.tlb
ys
mmph.ow
cystes
c. Memory t cells and effector t cells
d. Helper cells and antigen-presenting cells
e. Cytotoxic t lymphocytes and target cells
Ans: a
T cells can be classified into effector subsets that perform different effector
functions. Most effector t cells are either helper t lymphocytes, which enhance the
responses of other immune cells, including phagocytes and b cells, to infections, or
cytotoxic t lymphocytes, which directly kill infected cells. Natural killer cells are not
t lymphocytes.
Antigen-presenting cells usually are not t cells. Memory t cells are not effector t cells.
6. Which of the following cell types is required for all adaptive humoral immune responses?
a. Natural killer cells
b. Dendritic cells
c. Cytolytic t lymphocytes
d. B lymphocytes
e. Helper t lymphocytes
Ans: d
Humoral immune responses are antibody-mediated immune responses, and all
antibodies are made by b lymphocytes and no other cell type.
CELLULAR AND MOLECULAR
IMMUNOLOGY, 11TH EDITION (ABBAS,
2026), CHAPTER 1-21 | ALL CHAPTERS
,Table of contents
1. Properties and overview of immune responses
2. Cells and tissues of the immune system
3. Leukocyte circulation and migration into tissues
4. Innate immunity
5. Antibodies and antigens
6. Antigen presentation to t lymphocytes and the functions of mhc molecules
7. Immune receptors and signal transduction
8. Lymphocyte development and antigen receptor gene rearrangement
9. Activation of t lymphocytes
10. Differentiation and functions of cd4+ effector t cells
11. Differentiation and functions of cd8+ effector t cells
12. B cell activation and antibody production
13. Effector mechanisms of humoral immunity
14. Specialized immunity at epithelial barriers and in immune privileged tissues
15. Immunologic tolerance and autoimmunity
16. Immunity to microbes
17. Transplantation immunology
18. Immunity to tumors
19. Hypersensitivity disorders
20. Allergy
21. Congenital and acquired immunodeficiencies
,Chapter 01: properties and overview of immune responses
Abbas, lichtman, and pillai: cellular and molecular immunology, 11th edition
Multiple choice
1. The principal function of the immune system is:
a. Defense against cancer
b. Repair of injured tissues
c. Defense against microbial infections
d. Prevention of inflammatory diseases
e. Protection against environmental toxins
Ans: c
The immune system has evolved in the setting of selective pressures imposed by
microbial infections. Although immune responses to cancer may occur, the concept
that “immunosurveillance” against cancer is a principal function of the immune
system is controversial. Repair of injured tissues may be a secondary consequence
of the immune responses and inflammation. Although the immune system has
regulatory features that are needed to prevent excessive inflammation, prevention
of inflammatory diseases is not a primary function. The immune system can protect
against microbial toxins, but it generally does not offer protection against toxins of
nonbiologic origin.
2. Which of the following infectious diseases was prevented by the first
successful vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
Ans: c
In 1798, edward jenner reported the first intentional successful vaccination, which
was against smallpox in a boy, using material from the cowpox pustules of a
milkmaid. In 1980, smallpox was reported to be eradicated worldwide by a
vaccination program. Effective vaccines against tetanus toxin, rubella virus, and
poliovirus were developed in the 20th century and are widely used. There is no
effective vaccine against mycobacterium tuberculosis.
3. Which of the following is a unique property of the adaptive immune system?
a. Highly diverse repertoire of specificities for antigens
b. Self-nonself discrimination
c. Recognition of microbial structures by both cell-associated and soluble receptors
d. Protection against viral infections
e. Responses that have the same kinetics and magnitude on repeated
exposure to the same microbe
Ans: a
, Highly diverse repertoires of specificities for antigens are found only in t and b
lymphocytes, which are the central cellular components of the adaptive immune
system. Both the innate and the adaptive immune systems use cell-associated and
soluble receptors to recognize microbes, display some degree of self-nonself
discrimination, and protect against viruses. On repeated exposure to the same
microbe, the adaptive immune response becomes more rapid and of greater
magnitude; this is the manifestation of memory.
4. Antibodies and t lymphocytes are the respective mediators of which two
types of immunity?
a. Innate and adaptive
b. Passive and active
c. Specific and nonspecific
d. Humoral and cell-mediated
e. Adult and neonatal
Ans: d
Both b and t lymphocytes are principal components of adaptive immunity. B
lymphocytes produce antibodies, which are the recognition and effector molecules of
humoral immune responses to extracellular pathogens. T cells recognize and promote
eradication of intracellular pathogens in cell-mediated immunity. Passive and active
immunity both can be mediated by either b or t lymphocytes. Specific immunity is
another term for adaptive immunity. Both b and t lymphocytes participate in adult
adaptive immunity but are still developing in the neonatal period.
5. The two major functional classes of effector t lymphocytes are:
a. Helper t lymphocytes and cytotoxic t lymphocytes
b. Natural killer cells and cytowtowxw
ic.tlb
ys
mmph.ow
cystes
c. Memory t cells and effector t cells
d. Helper cells and antigen-presenting cells
e. Cytotoxic t lymphocytes and target cells
Ans: a
T cells can be classified into effector subsets that perform different effector
functions. Most effector t cells are either helper t lymphocytes, which enhance the
responses of other immune cells, including phagocytes and b cells, to infections, or
cytotoxic t lymphocytes, which directly kill infected cells. Natural killer cells are not
t lymphocytes.
Antigen-presenting cells usually are not t cells. Memory t cells are not effector t cells.
6. Which of the following cell types is required for all adaptive humoral immune responses?
a. Natural killer cells
b. Dendritic cells
c. Cytolytic t lymphocytes
d. B lymphocytes
e. Helper t lymphocytes
Ans: d
Humoral immune responses are antibody-mediated immune responses, and all
antibodies are made by b lymphocytes and no other cell type.
